Curcumin derivatives for Type 2 Diabetes management and prevention of complications

Oliveira, Sara Cioccari; Alfredo, Tamaeh Monteiro; Silva, Sónia; Matafome, Paulo

doi:10.1007/s12272-020-01240-3

Cited by 29 publications

(22 citation statements)

References 78 publications

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“…1 Chronic hyperglycemia can cause a variety of complications, including cardiovascular disease, kidney disease, retinal disease, and neurological disease. [2][3][4][5] Diabetes is currently one of the fastestgrowing chronic diseases. The number of patients with T2DM is increasing at alarming rates worldwide, and the current prevalence of 422 million people is expected to rise to 592 million in 2035.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus

Liu¹,

Lang²,

Shi³

2021

DMSO

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Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia which is caused by insufficient insulin secretion or insulin resistance. Interaction of genetic, epigenetic and environmental factors plays a significant role in the development of T2DM. Several environmental factors including diet and lifestyle, as well as age have been associated with an increased risk for T2DM. It has been demonstrated that these environmental factors may affect global epigenetic status, and alter the expression of susceptible genes, thereby contributing to the pathogenesis of T2DM. In recent years, a growing body of molecular and genetic studies in diabetes have been focused on the ways to restore the numbers or function of β-cells in order to reverse a range of metabolic consequences of insulin deficiency. The pancreatic duodenal homeobox 1 (PDX-1) is a transcriptional factor that is essential for the development and function of islet cells. A number of studies have shown that there is a significant increase in the level of DNA methylation of PDX-1 resulting in reduced activity in T2DM islets. The decrease in PDX-1 activity may be a critical mediator causing dysregulation of pancreatic β cells in T2DM. This article reviews the epigenetic mechanisms of PDX-1 involved in T2DM, focusing on diabetes and DNA methylation, and discusses some potential strategies for the application of PDX-1 in the treatment of diabetes.

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Section: Introductionmentioning

confidence: 99%

Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus

Liu¹,

Lang²,

Shi³

2021

DMSO

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“…Another beneficial effect is a reduction in total cholesterol, blood pressure, and platelet aggregation [ 172 , 173 ]. Curcumin decreases postprandial glycaemia and improves insulin sensitivity [ 128 ]. The mechanism of curcumin action is possible via the inhibition of lipid peroxidation, NF-κB activation, and the reduction of inflammatory cytokine levels.…”

Section: Treatment Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…The antitumor, antioxidant and antidiabetic effects of the fruit have been recorded in several studies. Strawberries have a beneficial impact on ageing, obesity, cardiovascular disease, and metabolic syndrome [ 128 , 211 ]. They can lower postprandial glucose concentrations and improve insulin sensitivity [ 161 , 162 ].…”

Section: Treatment Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

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Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

et al. 2021

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Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by chronic hyperglycaemia, insulin resistance, and inefficient insulin secretion and action. Primary care in T2DM is pharmacological, using drugs of several groups that include insulin sensitisers (e.g., biguanides, thiazolidinediones), insulin secretagogues (e.g., sulphonylureas, meglinides), alpha-glucosidase inhibitors, and the newest incretin-based therapies and sodium–glucose co-transporter 2 inhibitors. However, their long-term application can cause many harmful side effects, emphasising the importance of the using natural therapeutic products. Natural health substances including non-flavonoid polyphenols (e.g., resveratrol, curcumin, tannins, and lignans), flavonoids (e.g., anthocyanins, epigallocatechin gallate, quercetin, naringin, rutin, and kaempferol), plant fruits, vegetables and other products (e.g., garlic, green tea, blackcurrant, rowanberry, bilberry, strawberry, cornelian cherry, olive oil, sesame oil, and carrot) may be a safer alternative to primary pharmacological therapy. They are recommended as food supplements to prevent and/or ameliorate T2DM-related complications. In the advanced stage of T2DM, the combination therapy of synthetic agents and natural compounds with synergistic interactions makes the treatment more efficient. In this review, both pharmaceutical drugs and selected natural products, as well as combination therapies, are characterized. Mechanisms of their action and possible negative side effects are also provided.

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“…The plant is a natural Indian spice that belongs to the family Zingiberaceae. It contains proteins (6.3%), carbohydrates (69.4%), essential oils (5.8%), fat (5.1%), and curcuminoids (3-6%) [8]. Studies involving the medicinal properties of Curcuma longa suggest that it possesses activity against viral infection, amyloid aggregation, arthritis, cancer, oxidation, and inflammation, along with correlated therapeutic effects on IR and T2DM [5].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Curcuma longa in Insulin Resistance

Salzedas

Batista

Barbalho³

2020

EJMP

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Background: Curcumin is seen as an anti-hyperglycemic agent that acts by improving the expression of glucose transporters. It is also related to the reduction of glycosylated hemoglobin, improvement of insulin sensitivity, plasma lipids, and blood pressure. Aim: The purpose of this article is to review the effects of Curcuma longa in insulin resistance. Methodology: PUBMED and EMBASE databases were searched, and PRISMA (Preferred Reporting Items for a Systematic Review and Meta-analysis) guidelines were followed to build the review. Results: Nineteen Randomized Clinical Trials (RCTs) met the inclusion criteria and were described according to PICO (Population, Intervention, Comparison, and Outcomes). Conclusion: Curcumin could be considered in the therapeutic approach of patients with Insulin Resistance, once it is related to the reduction of oxidative stress, inflammation, serum fasting blood glucose, HOMA-IR, blood pressure, serum lipids, and liver transaminases. However, the results depend on the dose, intervention time, and formulation of the compound.Insulin resistance

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Curcumin derivatives for Type 2 Diabetes management and prevention of complications

Cited by 29 publications

References 78 publications

Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus

Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus

Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

The Effects of Curcuma longa in Insulin Resistance

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