Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

Pourmadadi, Mehrab; Abbasi, Parisa; Eshaghi, Mohammad Mahdi; Bakhshi, Ali; Manicum, Amanda-Lee E.; Rahdar, Abbas; Pandey, Sadanand; Jadoun, Sapana; Díez‐Pascual, Ana M.

doi:10.1016/j.jddst.2022.103982

Cited by 29 publications

(18 citation statements)

References 234 publications

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“…In addition, the CaP@Lip NPs have independent loading compartments and release channels for DOX and PTX, respectively, avoiding any potential drug interactions and improving the therapeutic efficacy of the drugs during their release from the NPs. In conclusion, drugs loaded in the NPs demonstrate the slower drug release and pH-dependent release compared to free drugs, achieving a more steady and sustained release while minimizing adverse effects on healthy cells, which are beneficial for the treatment of tumors. , …”

Section: Resultsmentioning

confidence: 94%

“…In conclusion, drugs loaded in the NPs demonstrate the slower drug release and pH-dependent release compared to free drugs, achieving a more steady and sustained release while minimizing adverse effects on healthy cells, which are beneficial for the treatment of tumors. 17,18 In order to confirm the delivery of drugs to cells through NPs, Rhodamine B was used to mark the NPs. First, the release behaviors of Rhodamine B from Rhodamine B-labeled CaP NPs and Rhodamine B-labeled CaP@Lip NPs were measured to provide proof for the retainment of the dye with the NPs as shown in Figure S5.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Cancer therapy remains a major medical challenge despite many strategies being developed, such as chemotherapy, photothermal therapy, and radiation therapy. − The concept of cancer treatment strategies based on the enhanced permeability and retention (EPR) effect has gained significant attention. Molecules or particles with specific sizes tend to aggregate in tumor tissues rather than in normal tissues. − Currently, dual-drug delivery (DDD) systems based on silica, polymer micelles, and liposomes nanoparticles (NPs) have been widely reported. − However, when using a single nanomaterial for DDD systems, its function may be limited, and it can be difficult to fully utilize its optimal properties. In contrast, DDD systems that can load and deliver two drugs have proven effective in overcoming drug resistance, reducing toxicity, and enabling combination therapy.…”

Section: Introductionmentioning

confidence: 99%

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Calcium Orthophosphate in Liposomes for Co-Delivery of Doxorubicin Hydrochloride/Paclitaxel in Breast Cancer

Chen

Guo

et al. 2023

Mol. Pharmaceutics

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Nanoparticles (NPs) show great advantages in cancer treatment by enabling controlled and targeted delivery of payloads to tumor sites through the enhanced permeability and retention (EPR) effect. In this study, highly effective pH-responsive and biodegradable calcium orthophosphate@liposomes (CaP@Lip) NPs with a diameter of 110 ± 20 nm were designed and fabricated. CaP@Lip NPs loaded with hydrophobic paclitaxel and hydrophilic doxorubicin hydrochloride achieved excellent drug loading efficiencies of 70 and 90%, respectively. Under physiological conditions, the obtained NPs are negatively charged. However, they switched to positively charged when exposed to weak acidic environments by which internalization can be promoted. Furthermore, the CaP@Lip NPs exhibit an obvious structural collapse under acid conditions (pH 5.5), which confirms their excellent biodegradability. The "proton expansion" effect in endosomes and the pH-responsiveness of the NPs facilitate the release of encapsulated drugs from individual channels. The effectiveness and safety of the drug delivery systems were demonstrated through in vitro and in vivo experiments, with a 76% inhibition of tumor growth. These findings highlight the high targeting ability of the drugloaded NPs to tumor sites through the EPR effect, effectively suppressing tumor growth and metastasis. By combining CaP NPs and liposomes, this study not only resolves the toxicity of CaP but also enhances the stability of liposomes. The CaP@Lip NPs developed in this study have significant implications for biomedical applications and inspire the development of intelligent and smart drug nanocarriers and release systems for clinical use.

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Section: Resultsmentioning

confidence: 94%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Calcium Orthophosphate in Liposomes for Co-Delivery of Doxorubicin Hydrochloride/Paclitaxel in Breast Cancer

Chen

Guo

et al. 2023

Mol. Pharmaceutics

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“…In our previous work, we discussed how the curcumin attaches on the GO surface thanks to the π–π binding, as previously demonstrated for other aromatic molecules, such as ginseng, vitamin C, melatonin, and polyphenols of green tea [ 31 ]. In this context, several research in the last years focused on the conjugation of CU with polymers, nanoparticles, and nanocarriers to increase its bioavailability [ 39 , 40 , 41 , 42 , 43 ]. In a recent paper published in 2021 [ 39 ], the authors describe the development of a nanocomposite film made of renewable castor oil-based PU (polyurethan) with curcumin-modified GO nanosheets for wound dressing.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Functionalized Graphene Oxide Strongly Prevents Candida parapsilosis Adhesion and Biofilm Formation

et al. 2023

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Candida parapsilosis is the major non-C. albicans species involved in the colonization of central venous catheters, causing bloodstream infections. Biofilm formation on medical devices is considered one of the main causes of healthcare-associated infections and represents a global public health problem. In this context, the development of new nanomaterials that exhibit anti-adhesive and anti-biofilm properties for the coating of medical devices is crucial. In this work, we aimed to characterize the antimicrobial activity of two different coated-surfaces, graphene oxide (GO) and curcumin-graphene oxide (GO/CU) for the first time, against C. parapsilosis. We report the capacity of GO to bind and stabilize CU molecules, realizing a homogenous coated surface. We tested the anti-planktonic activity of GO and GO/CU by growth curve analysis and quantification of Reactive Oxigen Species( ROS) production. Then, we tested the antibiofilm activity by adhesion assay, crystal violet assay, and live and dead assay; moreover, the inhibition of the formation of a mature biofilm was investigated by a viability test and the use of specific dyes for the visualization of the cells and the extra-polymeric substances. Our data report that GO/CU has anti-planktonic, anti-adhesive, and anti-biofilm properties, showing a 72% cell viability reduction and a decrease of 85% in the secretion of extra-cellular substances (EPS) after 72 h of incubation. In conclusion, we show that the GO/CU conjugate is a promising material for the development of medical devices that are refractory to microbial colonization, thus leading to a decrease in the impact of biofilm-related infections.

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“…We selected Doxorubicin (DOX) and curcumin (CUR) as co-delivery drug models, in which CUR can reduce MDR protein expressions, and attenuate the nonspecific systemic toxic effects of DOX. [28][29][30][31] Hyaluronic acid (HA) modified with β-cyclodextrin (β-CD) is considered as the outer 'shell' (HA-CD), and the oxidized form of ferrocene (Fc) combined with stearyl alcohol (C 18 ) can self-assemble to form micelles as the inner "core" (Fc + -C 18 ), where DOX and CUR are separately encapsulated into shell and core. Subsequently, negative charged HA-CD shell will spontaneously bind to Fc + -C 18 core, forming 'shell-core' bilayer nanoparticles (BNs) (HA-CD@DOX & Fc-C 18 @CUR).…”

Section: Introductionmentioning

confidence: 99%

“Shell-Core” Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects

Zeng¹,

Sun²,

Fang³

et al. 2023

IJN

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Background Synergistic chemotherapy has been proved as an effective antitumor means in clinical practice. However, most co-administration treatment often lacks simultaneous control over the release of different chemotherapeutic agents. Materials and Methods β -cyclodextrin modified hyaluronic acid was the “shell”, and the oxidized ferrocene-stearyl alcohol micelles served as the “core”, where doxorubicin (DOX) and curcumin (CUR) were loaded in shell and core of the bilayer nanoparticles (BNs), respectively. The pH- and glutathione (GSH)-responsive synchronized release behavior was evaluated in different mediums, and the in vitro and in vivo synergistic antitumor effect and CD44-mediated tumor targeting efficiency were further investigated. Results These BNs had a spherical structure with the particle size of 299 ± 15.17 nm, while the synchronized release behaviour of those two drugs was proved in the medium with the pH value of 5.5 and 20 mM GSH. The co-delivery of DOX and CUR reduced the IC 50 value by 21% compared to DOX alone, with a further 54% reduction after these BNs delivery measurements. In tumor-bearing mouse models, these drug-loaded BNs showed significant tumor targeting, enhanced antitumor activity and reduced systemic toxicity. Conclusion The designed bilayer nanoparticle could be considered as potential chemotherapeutic co-delivery platform for efficient synchronized microenvironment respond and drug release. Furthermore, the simultaneous and synergistic drug release guaranteed the enhanced antitumor effects during the co-administration treatment.

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Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

Cited by 29 publications

References 234 publications

Calcium Orthophosphate in Liposomes for Co-Delivery of Doxorubicin Hydrochloride/Paclitaxel in Breast Cancer

Calcium Orthophosphate in Liposomes for Co-Delivery of Doxorubicin Hydrochloride/Paclitaxel in Breast Cancer

Curcumin-Functionalized Graphene Oxide Strongly Prevents Candida parapsilosis Adhesion and Biofilm Formation

“Shell-Core” Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects

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