Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

Caillaud, Martial; Msheik, Zeina; Ndong-Ntoutoume, Gautier M.A.; Vignaud, Laetitia; Richard, Laurence; Favreau, Fréderic; Faye, Pierre-Antoine; Sturtz, Franck; Granet, Robert; Vallat, Jean‐Michel; Sol, Vincent; Desmoulière, Alexis; Billet, Fabrice

doi:10.1016/j.freeradbiomed.2020.09.019

Cited by 39 publications

(60 citation statements)

References 60 publications

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“…CUR–cyclodextrin/cellulose nanocrystals (CNCx) exerted more potent antiproliferative effect on prostate and colorectal cancer cell lines than CUR [ 26 ]. In addition, CNCx mitigated oxidative stress and improved myelination, and the cellular, electrophysiological, and functional characteristics of Charcot–Marie–Tooth-1A transgenic rats [ 27 ]. Recently, Iurciuc-Tincu et al have immobilized CUR into polysaccharide particles and reported increased stability and bioavailability [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

et al. 2021

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Copper (Cu) is essential for multiple biochemical processes, and copper sulphate (CuSO4) is a pesticide used for repelling pests. Accidental or intentional intoxication can induce multiorgan toxicity and could be fatal. Curcumin (CUR) is a potent antioxidant, but its poor systemic bioavailability is the main drawback in its therapeutic uses. This study investigated the protective effect of CUR and N-CUR on CuSO4-induced cerebral oxidative stress, inflammation, and apoptosis in rats, pointing to the possible involvement of Akt/GSK-3β. Rats received 100 mg/kg CuSO4 and were concurrently treated with CUR or N-CUR for 7 days. Cu-administered rats exhibited a remarkable increase in cerebral malondialdehyde (MDA), NF-κB p65, TNF-α, and IL-6 associated with decreased GSH, SOD, and catalase. Cu provoked DNA fragmentation, upregulated BAX, caspase-3, and p53, and decreased BCL-2 in the brain of rats. N-CUR and CUR ameliorated MDA, NF-κB p65, and pro-inflammatory cytokines, downregulated pro-apoptotic genes, upregulated BCL-2, and enhanced antioxidants and DNA integrity. In addition, both N-CUR and CUR increased AKT Ser473 and GSK-3β Ser9 phosphorylation in the brain of Cu-administered rats. In conclusion, N-CUR and CUR prevent Cu neurotoxicity by attenuating oxidative injury, inflammatory response, and apoptosis and upregulating AKT/GSK-3β signaling. The neuroprotective effect of N-CUR was more potent than CUR.

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Section: Introductionmentioning

confidence: 99%

Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

et al. 2021

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“…Muscle function was assessed with a grip strength meter (Bioseb, France) ( Caillaud et al, 2020 ). Mice were held by the tail over the mesh of the meter, and once the forepaws, but neither hind paw, were both firmly grasping the grid, the mice were pulled along the axis of the force sensor until they were unable to retain their grip.…”

Section: Methodsmentioning

confidence: 99%

Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice

et al. 2021

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Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia. The relationship between the sensory nervous system and modulation of the renin-angiotensin system has been described, focusing on pain and neurodegeneration in several animal models. We assessed the effect of the RAS modulator, ramipril, an angiotensin converting-enzyme inhibitor in a mouse model of OXP-induced acute pain syndrome. OXP was administered in Swiss mice at a cumulative dose of 15 mg/kg (3 x 5 mg/kg/3 days, i.p.). RAM was administered i.p. every day from 24 h before the first OXP injection until the end of the experiments. We evaluated OIAS development and treatment effects by sensorimotor tests, intraepidermal nerve fiber and dorsal root ganglia-neuron immunohistochemical analyses, and sciatic nerve ultrastructural analysis. OXP-treated mice showed tactile allodynia and cold hypersensitivity, without motor impairment and evidence of nerve degeneration. RAM prevented cold sensitivity and improved recovery of normal tactile sensitivity in OXP-treated mice. Our finding that RAM alleviates OXP-induced pain is a step towards evaluating its therapeutic potential in patients receiving OXP treatment.

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“…In order to overcome the limited pharmacokinetics of curcumin, curcumin-cyclodextin/cellulose nanoparticles were developed (Nano-Cur) [ 82 ]. In vitro and in vivo testing of Nano-Cur in the rat model of CMT1A showed reduction of reactive oxygen species (ROS) and improved mitochondrial membrane potential and integrity, leading to improvement of myelination and nerve function [ 111 ].…”

Section: Emerging Treatments For Demyelinating Cmt Neuropathiesmentioning

confidence: 99%

Emerging Therapies for Charcot-Marie-Tooth Inherited Neuropathies

Stavrou

Sargiannidou

Georgiou

et al. 2021

IJMS

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Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically heterogeneous disorders affecting the peripheral nerves, causing significant and slowly progressive disability over the lifespan. The discovery of their diverse molecular genetic mechanisms over the past three decades has provided the basis for developing a wide range of therapeutics, leading to an exciting era of finding treatments for this, until now, incurable group of diseases. Many treatment approaches, including gene silencing and gene replacement therapies, as well as small molecule treatments are currently in preclinical testing while several have also reached clinical trial stage. Some of the treatment approaches are disease-specific targeted to the unique disease mechanism of each CMT form, while other therapeutics target common pathways shared by several or all CMT types. As promising treatments reach the stage of clinical translation, optimal outcome measures, novel biomarkers and appropriate trial designs are crucial in order to facilitate successful testing and validation of novel treatments for CMT patients.

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Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

Cited by 39 publications

References 60 publications

Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

Ramipril Alleviates Oxaliplatin-Induced Acute Pain Syndrome in Mice

Emerging Therapies for Charcot-Marie-Tooth Inherited Neuropathies

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