Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

Lazar, Adina N.; Mourtas, Spyridon; Youssef, Ihsen; Parizot, Christophe; Dauphin, Aurélien; Delatour, Benoı̂t; Antimisiaris, Sophia G.; Duyckaerts, Charles

doi:10.1016/j.nano.2012.11.004

Cited by 139 publications

(79 citation statements)

References 35 publications

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“…In this way, intracranial injection of liposomes encapsulating curcumin efficiently labeled Aβ deposits in both human and mice tissues, proving to be an effective formulation for diagnosis and treatment of AD. 113 Also, intraperitoneal injection of liposomes containing phosphatidic acid or cardiolipin was able to reduce Aβ peptides in the plasma and shifted the equilibrium that exists between brain and blood Aβ peptides, slightly affecting the plaques in the brain. 89 Lastly, different liposome-based vaccines were developed and directed toward Aβ plaques 115,116 and tau.…”

Section: Data Extractionmentioning

confidence: 99%

“…84,85 Although the scope of this review is on liposome-strategies with the aim of facilitating BBB crossing, it is important to mention that other strategies have been developed for the use of liposomes for AD treatment. 89,[113][114][115][116] Curcumin is a natural compound extract from the plant Curcuma longa, and has been reported to be a fluorescent molecule with high affinity for the Aβ peptide and able to reduce Aβ aggregation. In this way, intracranial injection of liposomes encapsulating curcumin efficiently labeled Aβ deposits in both human and mice tissues, proving to be an effective formulation for diagnosis and treatment of AD.…”

Section: Data Extractionmentioning

confidence: 99%

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Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira

Gamarra

2016

IJN

348

238

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This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered.

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Section: Data Extractionmentioning

confidence: 99%

Section: Data Extractionmentioning

confidence: 99%

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira

Gamarra

2016

IJN

348

238

View full text Add to dashboard Cite

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“…Oxidative damage and inflammatory processes are known to be particularly high in the brains of Alzheimer patients, and as the aqueous extract of turmeric reduces and prevents oxidation, it may be used concurrently in long-term therapy (46)(47)(48)(49).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Biological and therapeutic activities, and anticancer properties of curcumin

Perrone

Ardito

Giannatempo

et al. 2015

Experimental and Therapeutic Medicine

259

192

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Abstract. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

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“…It is a polyphenolic ingredient which is considered as major antioxidant, coloring and flavoring agent in the balanced diet (Yao et al 2011). Several studies have been published reporting pluripotent pharmacolological actions of Curcumin e.g., anticancer (Ketron and Osheroff 2014), antiretroviral (Barthelemy et al 1998), antiinflammatory (Kant et al 2014), antidiabetic (Zhang et al 2013), antidepressant (Pathak et al 2013), anti-alzheimer (Lazar et al 2013), antioxidant (Khalil and Ali 2011), antibacterial (Gunes et al 2013), antifungal (Sharma 2012) etc. These varied medicinal benefits also suggest application of this extraordinary molecule as a functional food (nutraceutical) ingredient.…”

Section: Introductionmentioning

confidence: 99%

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

2015

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The supramolecular nano-assemblies formed by electrostatic interactions of two oppositely charged lipid and polymer have been made and used as nanocarriers for curcumin to address its bioavailability and solubility issues. These curcumin encapsulated nano-supramolecular assemblies were characterized with respect to their size (dynamic light scattering), morphology (TEM, SEM), zeta potential (Laser Doppler Velocimetry), encapsulation efficiency (EE), curcumin loading (CL) etc. Stability of the nano-assemblies was assessed at different storage times as a function of varying pH and temperature. The physicochemical characterization of nano-assemblies was performed using Fourier Transform Infra Red Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC). The in-vitro antioxidant lipid peroxidation (TBARS), radical scavenging (DPPH, NO, H 2 O 2 , reducing power) activity assays of powdered curcumin and nanoencapsulated curcumin were performed. It was found that nano-encapsulated curcumin were roughly spherical in shape, presented high positive zeta potential (>30 mV), monodisperse (polydispersity index <0.3), amorphous in nature, stable in the pH range of 2-6 and have enhanced antioxidant potency in comparison to crystalline curcumin in aqueous media. In conclusion, the curcumin encapsulated nanocarriers system has great potential as functional food ingredient of natural origin.

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Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

Cited by 139 publications

References 35 publications

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Biological and therapeutic activities, and anticancer properties of curcumin

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

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Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease

Cited by 139 publications

References 35 publications

Getting into the brain: liposome-based strategies for effective drug delivery across the blood&ndash;brain barrier

Getting into the brain: liposome-based strategies for effective drug delivery across the blood&ndash;brain barrier

Biological and therapeutic activities, and anticancer properties of curcumin

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

Contact Info

Product

Resources

About

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier