Curcumin Cocrystal Micelles—Multifunctional Nanocomposites for Management of Neurodegenerative Ailments

Desai, Preshita; Patravale, Vandana

doi:10.1016/j.xphs.2017.11.014

Cited by 47 publications

(25 citation statements)

References 36 publications

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“…This formulation could be useful for the intranasal use (Desai & Patravale, 2017). This product was found to be more brain available with superior antioxidant potency compared with curcumin alone (Desai & Patravale, 2017).…”

Section: Bioavailability Issue With Curcuminmentioning

confidence: 98%

“…The brain availability of curcumin could be enhanced by using different techniques. In one of these strategies, cocrystals of curcumin with the antioxidant hydrophilic conformer could be developed and incorporated into the micellar nanocarrier (Desai & Patravale, ). This formulation could be useful for the intranasal use (Desai & Patravale, ).…”

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

“…In one of these strategies, cocrystals of curcumin with the antioxidant hydrophilic conformer could be developed and incorporated into the micellar nanocarrier (Desai & Patravale, ). This formulation could be useful for the intranasal use (Desai & Patravale, ). This product was found to be more brain available with superior antioxidant potency compared with curcumin alone (Desai & Patravale, ).…”

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

“…This formulation could be useful for the intranasal use (Desai & Patravale, ). This product was found to be more brain available with superior antioxidant potency compared with curcumin alone (Desai & Patravale, ). The relative bioavailability was also enhanced to 4.5–6 folds with the micellar and cocrystal micellar formulations (Desai & Patravale, ).…”

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

“…Curcumin is a potent antioxidant and anti-inflammatory molecule (Ak & Gulcin, 2008;Barclay et al, 2000;Desai & Patravale, 2017;Menon & Sudheer, 2007). The neuroinflammation and oxidative stress are the two principal pathophysiological hallmarks of epilepsy and seizure disorders (Huang et al, 2017;Wyatt, Witt, Barbaro, Cohen-Gadol, & Brewster, 2017).…”

Section: Anti-inflammatory and Antioxidant Effects Of Curcuminmentioning

confidence: 99%

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Curcumin in epilepsy disorders

Dhir

2018

Phytotherapy Research

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Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy. The antioxidant and anti-inflammatory nature of curcumin might be responsible for its observed anti-seizure effects; nevertheless, the exact mechanism is not yet clear. The poor availability of curcumin to the brain limits its use in clinics. The application of nanoliposome and liposome technologies has been tested to enhance its brain availability and penetrability. Unfortunately, there are no randomized, double-blinded controlled clinical trials validating the use of curcumin in epilepsy. The present article analyzes different preclinical evidence illustrating the effect of curcumin in seizure models. The review encourages carrying out clinical trials in this important area of research. In conclusion, curcumin might be beneficial in patients with epilepsy disorders, if its bioavailability issues are resolved.

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Section: Bioavailability Issue With Curcuminmentioning

confidence: 98%

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

Section: Anti-inflammatory and Antioxidant Effects Of Curcuminmentioning

confidence: 99%

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Curcumin in epilepsy disorders

Dhir

2018

Phytotherapy Research

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Nanodelivery of Polyphenols as Nutraceuticals for Neurological Disorders

Paul,

Gogoi,

Zaman

2023

Polyphenols

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Delivery Mechanism of the Pharmaceutical Complex of Genistein‐Adenine Based on Spectroscopic and Molecular Modelling at Atomic Scale

Shao

Guo²,

Zhao

et al. 2021

Chemistry & Biodiversity

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Genistein (GS) exhibits various biological activities, but its clinical application is limited because of the low bioavailability. In this study, a GS‐adenine pharmaceutical complex was prepared through solvent evaporation to improve the bioavailability of GS, and a molecular model of a two‐component supramolecular pharmacological transport mechanism was established. The structure of GS‐adenine was characterized, in addition, interaction patterns between GS and adenine were investigated using density functional theory. The results showed that the solubility of GS‐adenine was five times higher than that of GS, and the cumulative release rate of GS‐adenine was 86 %. The results of fluorescence spectroscopy and molecular dynamic simulations showed that GS‐adenine bound to the Sudlow's site I of HSA mainly through hydrophobic interactions. This study provides a useful reference for synthesizing pharmaceutical complexes to improve solubility and for exploring the mechanism of multiple pharmaceutical components in vivo.

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Curcumin Cocrystal Micelles—Multifunctional Nanocomposites for Management of Neurodegenerative Ailments

Cited by 47 publications

References 36 publications

Curcumin in epilepsy disorders

Curcumin in epilepsy disorders

Nanodelivery of Polyphenols as Nutraceuticals for Neurological Disorders

Delivery Mechanism of the Pharmaceutical Complex of Genistein‐Adenine Based on Spectroscopic and Molecular Modelling at Atomic Scale

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