Curcumin coated 3D biocomposite scaffolds based on chitosan and cellulose for diabetic wound healing

Gupta, Megha; Sharma, Aradhana; Beniwal, Chandra Shekhar; Tyagi, Priyanka

doi:10.1016/j.heliyon.2022.e11442

Cited by 12 publications

(5 citation statements)

References 41 publications

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“…From stress-strain curves ( Figure 10 ), the tensile strength, Young’s modulus, and elongation at break for pure CS, CS/Cel, CS/HH and CS/Cur at different concentrations were calculated and presented in Figure 11 . Pure CS film shows low tensile strength, which is due to its low water resistance properties, and this gives chitosan its poor mechanical properties [ 64 , 65 , 66 , 67 ]. In order to improve these properties, CS films were blended with natural materials because chitosan films with higher tensile strength and reasonable elongation at break values have a higher potential in medical and other applications [ 68 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

Improvement of Chitosan Films Properties by Blending with Cellulose, Honey and Curcumin

Madian,

El-Ashmanty,

Abdel-Rahim

2023

Polymers

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Chitosan is a natural biopolymer that can be used in biomedical applications, tissue engineering, and wound dressing because of its biodegradability, biocompatibility, and antibacterial activity. The blending of chitosan films with natural biomaterials such as cellulose, honey, and curcumin was studied at different concentrations in order to improve their physical properties. Fourier transform infrared (FTIR) spectroscopy, mechanical tensile properties, X-ray diffraction (XRD), antibacterial effects, and scanning electron microscopy (SEM) were studied for all blended films. The XRD, FTIR, and mechanical results showed that films blended with curcumin were more rigid and compatible and had higher antibacterial effects than other blended films. In addition, XRD and SEM showed that blending chitosan films with curcumin decreases the crystallinity of the chitosan matrix compared to cellulose and honey blending films due to increased intermolecular hydrogen bonding, which reduces the close packing of the CS matrix.

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Section: Resultsmentioning

confidence: 99%

Improvement of Chitosan Films Properties by Blending with Cellulose, Honey and Curcumin

Madian,

El-Ashmanty,

Abdel-Rahim

2023

Polymers

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“…These bioscaffolds, crafted from a myriad of natural and synthetic biomaterials, can perform simultaneous functions such as the delivery of bioactive agents and pharmaceutical molecules, control of stem cell behavior, and guidance of cellular growth and differentiation [170,171]. The design of multifunctional bioscaffolds, actively involved in providing biological cues to guide and stimulate cellular activities like attachment, proliferation, migration, growth, and differentiation, is extensively researched using organic, inorganic, and hybrid (organic-inorganic) materials [172,173]. Application of such multifunctional bioscaffolds has demonstrated varied degrees of success in skin regeneration across both in vitro and in vivo models [174][175][176][177][178][179], necessitating controlled attributes such as homogeneous porous 3D structure, interconnected porosity, and mechanical properties to facilitate carriage of cells and bioactive molecules for wound healing and skin regeneration [180].…”

Section: Further Directions 4321 Multifunctional Biological Scaffoldmentioning

confidence: 99%

Analysis of bioprinting strategies for skin diseases and injuries through structural and temporal dynamics: historical perspectives, research hotspots, and emerging trends

Teng,

Wang,

Wang

et al. 2024

Biofabrication

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Objective:This study endeavors to investigate the progression, research focal points, and budding trends in the realm of skin bioprinting over the past decade from a structural and temporal dynamics standpoint.Methods:Scholarly articles on skin bioprinting were obtained from WoSCC. A series of bibliometric tools comprising R software, CiteSpace, HistCite, and an alluvial generator were employed to discern historical characteristics, evolution of active topics, and upcoming tendencies in the area of skin bioprinting.Findings:Over the past decade, there has been a consistent rise in research interest in skin bioprinting, accompanied by an extensive array of meaningful scientific collaborations. Concurrently, diverse dynamic topics have emerged during various periods, as substantiated by an aggregate of 22 disciplines, 74 keywords, and 187 references demonstrating citation bursts. Four burgeoning research subfields were discerned through keyword clustering - namely, #3 "in situ bioprinting", #6 "vascular", #7 "xanthan gum", and #8 "collagen hydrogels". The keyword alluvial map reveals that Module 1, including "transplantation" etc., has primarily dominated the research module over the previous decade, maintaining enduring relevance despite annual shifts in keyword focus. Additionally, we mapped out the top six key modules from 2023 being "silk fibroin nanofiber", "system", "ionic liquid", "mechanism", and "foot ulcer". Three recent research subdivisions were identified via timeline visualization of references, particularly Clusters #0 "wound healing", #4 "situ mineralization", and #5 "3D bioprinter".Conclusion:Insights derived from bibliometric analyses illustrate present conditions and trends in skin bioprinting research, potentially aiding researchers in pinpointing central themes and pioneering novel investigative approaches in this field.

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“…In the year 2021 [44], researchers studied PLA biomedical applications. During the last decade, biodegradable materials have been extensively studied for medical applications because they Synthetic biodegradable polymers, such as polyhydroxy acids (e.g., poly(glycolic acid) (PGA), poly(lactic acid) (PLA), and polydioxanone (PDS)), offer several advantages over nondegradable biomaterials.…”

Section: Applicationsmentioning

confidence: 99%

A Review on Biofiber-Reinforced Polyhydroxybutyrate (PHB) and Polylactic Acid (PLA) Composites

2023

IRJMETS

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The most important problem now is environmental pollution, which includes contamination of the air, water, and soil. In general, soil pollution harms the fields and renders them infertile, which is a serious worry. Agrowaste is one of the sources of soil pollution. Reusing this agricultural waste, specifically Natural fibers (NFs), by blending them with polymer-based materials to reinforce the polymer composite may be able to reduce the pollution caused by agro-waste. There are benefits and drawbacks to this strategy, though. As a result, from the perspective of mechanical characteristics, polymer composite materials made with NFs are subpar compared to polymer composites reinforced by, for example, carbon or glass fibers. Due to their renewable, biodegradable, and environmentally benign qualities, NFs can be extremely important in the textile and composites industries.In terms of both industrial applications and fundamental research, the natural fiber-reinforced polymer composite is expanding quickly. NFs are becoming more important as a result of environmental concerns due to their eco-friendliness. Since NF is a plentiful resource, the creation of NF composites will enable the replacement of current materials in a variety of applications. They are cheap, biodegradable, fully or partially recyclable, renewable, and renewable. Due to their low cost and low density as well as their good mechanical qualities, these composites are appealing due to the ease with which raw materials are accessible and renewable. Usually, continuous (very long) or discontinuous (chopped) NFs are utilized as reinforcement in composites. Given that NFs have superior mechanical qualities to synthetic fibers, there is growing interest in employing them to create high-performance technical products.

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Curcumin coated 3D biocomposite scaffolds based on chitosan and cellulose for diabetic wound healing

Cited by 12 publications

References 41 publications

Improvement of Chitosan Films Properties by Blending with Cellulose, Honey and Curcumin

Improvement of Chitosan Films Properties by Blending with Cellulose, Honey and Curcumin

Analysis of bioprinting strategies for skin diseases and injuries through structural and temporal dynamics: historical perspectives, research hotspots, and emerging trends

A Review on Biofiber-Reinforced Polyhydroxybutyrate (PHB) and Polylactic Acid (PLA) Composites

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