Curcumin Chalcone Derivatives Database (CCDD): a Python framework for natural compound derivatives database

Rampogu, Shailima; Balasubramaniyam, Thananjeyan; Lee, Joon-Hwa

doi:10.7717/peerj.15885

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Previous studies have primarily focused on using alkali/urea to enhance the stability and mechanical properties of CS. 30 Cur, a naturally and typically occurring chalcone obtained from plants, 31 can undergo the Michael addition reaction with amino groups under alkaline conditions. Therefore, CS/Cur is covalently crosslinked with the amino groups of CS and chalcone groups in Cur to yield a homogeneous and transparent mixture of CS/Cur by the chalcone-Michael addition reaction in alkali.…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

Fan,

Huang,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the wound area. Therefore, it is of great importance to develop a novel multifunctional hydrogel with high efficiency to accelerate diabetic wound healing. Curcumin (Cur), a Chinese herbal, has shown great potential in enhancing the healing of diabetic chronic wounds because of its immunomodulatory and pro-angiogenic properties. However, its low aqueous solubility, poor bioavailability, and chemical instability have limited its clinical applications. To address these current bottlenecks, novel poly(vinyl alcohol) (PVA)− chitosan (CS)/sodium alginate (SA)−Cur (PCSA) hydrogels were prepared for the first time, and they demonstrated all of the above intriguing performances by the Michael addition reaction of CS and Cur. PCSA hydrogels show multiple dynamic bonds, which possess strong mechanical properties (tensile stress: ∼0.980 MPa; toughness: ∼258.45 kJ/m 3 ; and compressive strength: ∼7.38 MPa at strain of 80%). These intriguing performances provided an optimal microenvironment for cell migration and proliferation and also promoted the growth of blood vessels, leading to early angiogenesis. Importantly, the experimental results demonstrated that PCSA hydrogels can effectively transform pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages without the need for additional ingredients in vitro. Benefiting from these characteristics, a full-thickness diabetic wound in a rat model demonstrated that PCSA hydrogels can effectively accelerate wound healing via ROS-scavenging, downregulation of IL-1β, and upregulation of CD31 expression, resulting in angiogenesis and collagen deposition. This strategy not only provides a simple and safe Cur-based hydrogel for diabetic wound healing but also highlights the significant potential for the development of high-performance biomaterials for promoting diabetic wound healing using traditional Chinese medicine.

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Section: Introductionmentioning

confidence: 99%