Curcumin blocks brain tumor formation

Purkayastha, Sudarshana; Berliner, Alexandra; Fernando, Suraj Shawn; Ranasinghe, Buddima; I, Ray; Tariq, Hussnain; Banerjee, Probal

doi:10.1016/j.brainres.2009.01.066

Cited by 124 publications

(128 citation statements)

References 24 publications

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“…Curcumin as a polyphenol gets attention in blocking brain tumor formation in a study. The chemopreventive and anticarcinogenic action of curcumin is shown and suggested as this might be due to its ability to inhibit proteins that initiate protective signals (Purkayastha, et al, 2009). …”

Section: Therapy Via Natural Antioxidantsmentioning

confidence: 99%

The Stance of Antioxidants in Brain Tumors

Atukeren¹,

Yiğitoğlu²

2013

Clinical Management and Evolving Novel Therapeutic Strategies for Patients With Brain Tumors

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Section: Therapy Via Natural Antioxidantsmentioning

confidence: 99%

The Stance of Antioxidants in Brain Tumors

Atukeren¹,

Yiğitoğlu²

2013

Clinical Management and Evolving Novel Therapeutic Strategies for Patients With Brain Tumors

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“…Curcumin exhibits cancer growth inhibition both in vitro and in vivo [5,6]: it suppresses cell proliferation in a variety of cancer cell lines and it inhibits tumorigenesis [7][8][9][10][11][12][13][14][15][16][17]. Multiple mechanisms of action are likely responsible for Curcumin various effects on cancer cells: G1/S arrest and apoptosis induction have been observed other than the mitotic block in different tumor cell lines [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Curcumin derivatives: Molecular basis of their anti-cancer activity

Basile

Ferrari

Lazzari

et al. 2009

Biochemical Pharmacology

166

129

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Curcumin, a phenolic compound from the plant Curcuma longa L., has shown a wide-spectrum of chemopreventive, anti-oxidant and anti-tumor properties. Although its promising chemotherapeutic activity, preclinical and clinical studies highlight Curcumin limited therapeutic application due to its instability in physiological conditions. To improve its stability and activity, many derivatives have been synthesized and studied, among which bis-DemethoxyCurcumin (bDMC) and diAcetylCurcumin (DAC). In this report, we show that both bDMC and DAC are more stable than Curcumin in physiological medium. To explore the mechanism of their chemotherapeutic effect, we studied their role in proliferation in the HCT116 human colon cancer cells. We correlated kinetic stability and cellular uptake data to their biological effects. Both bDMC and DAC impair correct spindles formation and induce a p53-and p21 CIP1/WAF1 -independent mitotic arrest, which is more stable and long-lasting for bDMC. A subsequent p53/p21 CIP1/WAF1 -dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing postmitotic cells from re-entering the cell cycle. Conversely, the G1/S arrest induced by bDMC is a direct effect of the drug and concomitant to the mitotic block. Finally, we demonstrate that bDMC induces rapid DNA double-strand breaks, moving for its possible development in anti-cancer clinical applications.

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“…In the Akt-related pathway, curcumin has been verified to inhibit phosphorylation of Akt in several cancer cell lines such as prostate cancer, leukemia, and even malignant brain tumor (5,9,17). Nevertheless, the phosphorylation of Akt was not influenced by curcumin significantly in this experimental cell line.…”

Section: Discussionmentioning

confidence: 80%

“…Nevertheless, most previously identified mechanisms are related to the apoptotic pathway (9). For example, Pratibha and colleagues examined and compared the efficacy of three curcuminoids through Bcl-2-mediated apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…In malignant brain tumors, curcumin also exhibits its pleiotropic activity, which includes inducing cell cycle arrest at the G2/M stage through up-regulation of ING4, suppressing tumor growth by inhibition of AP-1 and NF-κB, and inhibiting anti-apoptotic signaling by increasing the Bax to Bcl-2 ratio (7)(8)(9). Nevertheless, most failure of cancer therapy in clinical practice is attributed to the polymorphism of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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The anti-cancer efficacy of curcumin scrutinized through core signaling pathways in glioblastoma

Wang²,

Chiu³

2010

Int J Mol Med

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Abstract. Curcumin has been verified as an anti-cancer compound via multiple molecular targets. Its effective mechanisms include cell cycle arrest, inducing apoptosis, suppressing oncogenes, and enhancing tumor suppressor genes. The resistance of cells to chemotherapy, however, derives from the variable genetic aberration of cancer cells. Consequently, the core signaling pathways of glioblastoma have been explored to evaluate the efficacy of curcumin in proceeding through mutated genes in those pathways. In this study, the efficacy of curcumin was investigated in DBTRG cells. The cytotoxic ability was detected with MTT assay, and the influence of the cell cycle was checked with flow cytometry. The influence of the core signaling pathways was evaluated by Western blotting through the predominantly mutated proteins which included p53, p21, and cdc2 in the p53 pathway, CDKN2A/p16 and RB in the RB pathway, and EGFR, mTOR, Ras, PTEN, and Akt in the RTK-Ras-PI3K pathway. In addition, the apoptotic effect was determined by apoptosis-associated proteins Bcl-2, Bax, and caspase 3. Curcumin exhibits superior cytotoxicity on glioblastoma in a dose-and time-dependent manner in the MTT assay. In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB. In the apoptotic pathway, the Bax and caspase 3 are significantly suppressed by curcumin and the Giemsa stain elucidates apoptotic features of DBTRG cells as well. In conclusion, curcumin appears to be an effective antiglioblastoma drug through inhibition of the two core signaling pathways and promotion of the apoptotic pathway.

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Curcumin blocks brain tumor formation

Cited by 124 publications

References 24 publications

The Stance of Antioxidants in Brain Tumors

The Stance of Antioxidants in Brain Tumors

Curcumin derivatives: Molecular basis of their anti-cancer activity

The anti-cancer efficacy of curcumin scrutinized through core signaling pathways in glioblastoma

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