Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats

Dietary Protection against Cognitive Impairment, Neuroinflammation and Oxidative Stress in Alzheimer’s Disease Animal Models of Lipopolysaccharide-Induced Inflammation

“…While curcumin ameliorates cognitive decline and synaptic functions in LPS-treated animals [ 46 , 47 ] in agreement with the findings obtained in both in vivo and in vitro other models of AD [ 76 ], to date, clinical studies on elderly individuals and patients with AD are still few or ongoing and indicate that curcumin is more effective in improving cognitive function in the elderly than in improving symptoms of AD [ 77 , 78 ].…”

“…In another study, Hajipour et al [ 47 ] administered curcumin for 14 days to male rats before a single LPS i.p. injection in order to protect from cognitive decline and neuroinflammation.…”

“…Curcumin was effective in protecting from memory impairment in the PA test. Furthermore, the curcumin supplementation prevented neuronal loss in the hippocampal cornu ammonis 1 (CA1) and dentate gyrus (DG) and recovered DG long-term potentiation (LTP) impairment induced by LPS [ 47 ].…”

“…As demonstrated in some articles here reviewed, LPS injection up-regulated the release of TNF-α, IL-1β [ 46 , 47 , 52 , 53 , 54 ], MIP-1α [ 52 ] and MCP-1 [ 54 ] and down-regulated IL-10 expression [ 54 ] in the brain. Curcumin, TD, hesperetin and Se-Ps were efficacious in returning LPS-induced release of pro-inflammatory cytokines TNF-α and IL-1β to physiological levels [ 46 , 47 , 52 , 53 , 54 ].…”

“…As demonstrated in some articles here reviewed, LPS injection up-regulated the release of TNF-α, IL-1β [ 46 , 47 , 52 , 53 , 54 ], MIP-1α [ 52 ] and MCP-1 [ 54 ] and down-regulated IL-10 expression [ 54 ] in the brain. Curcumin, TD, hesperetin and Se-Ps were efficacious in returning LPS-induced release of pro-inflammatory cytokines TNF-α and IL-1β to physiological levels [ 46 , 47 , 52 , 53 , 54 ]. In particular, the beneficial effects of curcumin in LPS-injected mice were mediated by TNFR-2 signaling [ 46 ], which is involved in the promotion of anti-inflammatory pathways in microglia [ 125 ] and protects against excitotoxity in neuropathological conditions [ 126 ].…”