Abstract:<b><i>Background:</i></b> Recent studies have shown that curcumin can reduce the symptoms of hydrocephalus. However, the underlying mechanisms remain unclear. Our previous studies demonstrated that E2F transcription factor 4 (E2F4) protein plays an important role in hydrocephalus; hence, we hypothesized that E2F4 may involve in curcumin mediated anti-hydrocephalus benefits. <b><i>Methods:</i></b> E2F4 expression and functions in different human tissues and cell l… Show more
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