Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis

Liu, Junmin; Li, Min; Luo, Wei; Sun, Hongbo

doi:10.1038/s41374-021-00640-3

Cited by 29 publications

(17 citation statements)

References 46 publications

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“…Curcumin decreases the resistance to Adriamycin via altering the expression of some microRNAs including miR-29b-1-5p [ 141 ]. Overcoming Adriamycin-resistance has also been examined in human acute myeloid leukemia cells (HL-60) [ 142 ]. It seems that miR-20a-5p mediates the anti-resistant effects of curcumin in these cells and, overall, the HOTAIR/miR-20a-5p/WT1 pathway is the reason that curcumin can sensitize AML cells to Adriamycin (in vitro and in vivo) [ 142 ].…”

Section: Polyphenols Modulate Cancer Drug Resistancementioning

confidence: 99%

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

et al. 2022

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Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading to failure of treatment and recurrence of the disease. Polyphenols are a family of organic compounds with more than 10,000 members which have a three-membered flavan ring system in common. These natural compounds are known for their beneficial properties, such as free radical scavenging, decreasing oxidative stress, and modulating inflammation. Herein, we discuss the role of polyphenols (mainly curcumin, resveratrol, and epigallocatechin gallate [EGCG]) in different aspects of cancer drug resistance. Increasing drug uptake by tumor cells, decreasing drug metabolism by enzymes (e.g. cytochromes and glutathione-S-transferases), and reducing drug efflux are some of the mechanisms by which polyphenols increase the sensitivity of cancer cells to chemotherapeutic agents. Polyphenols also affect other targets for overcoming chemoresistance in cancer cells, including cell death (i.e. autophagy and apoptosis), EMT, ROS, DNA repair processes, cancer stem cells, and epigenetics (e.g. miRNAs).

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Section: Polyphenols Modulate Cancer Drug Resistancementioning

confidence: 99%

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

et al. 2022

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“…Therefore, BMSC transplantation has been considered as a promising method for treating OA [ 35 ]. Recently, miR-20a-5p attracts increasing attention and is implicated in multiple diseases [ 36 , 37 ]. Nevertheless, the specific role of miR-20a-5p in OA has not been reported.…”

Section: Discussionmentioning

confidence: 99%

MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2

et al. 2022

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Bone marrow mesenchymal stem cell (BMSC) chondrogenic differentiation contributes to the treatment of osteoarthritis (OA). Numerous studies have indicated that microRNAs (miRNAs) regulate the pathogenesis and development of multiple disorders, including OA. Nevertheless, the role of miR-20a-5p in OA remains obscure. Forty male C57BL/6 mice were divided into four groups and were surgically induced OA or underwent sham surgery in the presence or absence of miR-20a-5p. Flow cytometry was implemented to detect surface markers of BMSCs. Reverse transcription quantitative polymerase chain reaction revealed the upregulation of miR-20a-5p during BMSC chondrogenic differentiation. Western blotting displayed that miR-20a-5p inhibition decreased protein levels of cartilage matrix markers but enhanced those of catabolic and hypertrophic chondrocyte markers in BMSCs. Alcian blue staining, hematoxylin‑eosin staining and micro-CT revealed that miR-20a-5p inhibition restrained chondrogenic differentiation and miR-20a-5p overexpression promoted the repair of damaged cartilage and subchondral bone, respectively. Luciferase reporter assay identified that mitogen activated protein kinase kinase kinase 2 (Map3k2) was a target of miR-20a-5p in BMSCs. Moreover, the expression of miR-20a-5p and Map3k2 was negatively correlated in murine cartilage tissues. Knocking down Map3k2 could rescue the suppressive influence of miR-20a-5p inhibition on chondrogenic differentiation of BMSCs. In conclusion, miR-20a-5p facilitates BMSC chondrogenic differentiation and contributes to cartilage repair in OA by suppressing Map3k2.

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“…H19, especially, which has been the subject of about 60 recent publications linked to EMT in cancer, was found to be attenuated in tamoxifen-resistant breast cancer cells after curcumin treatment (Cai et al, 2021b). Among new findings, curcumin's potential role in the treatment of resistant acute myeloid leukemia was shown to involve inhibition of the HOTAIR/miR-20a-5p/WT1 axis (Liu J. M. et al, 2021). Moreover, the inhibition of Warburg effect produced by curcumin in invasive thyroid cancer cells, linked to a reduction of the expression of another lncRNA, LINC00691, appeared to involve the Akt signaling pathway (Li Z. et al, 2022).…”

Section: Non-coding Rnas As New Targets Of Curcuminoidsmentioning

confidence: 98%

Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies

et al. 2022

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Curcuminoids, which include natural acyclic diarylheptanoids and the synthetic analogs of curcumin, have considerable potential for fighting against all the characteristics of invasive cancers. The epithelial-to-mesenchymal transition (EMT) is a fundamental process for embryonic morphogenesis, however, the last decade has confirmed it orchestrates many features of cancer invasiveness, such as tumor cell stemness, metabolic rewiring, and drug resistance. A wealth of studies has revealed EMT in cancer is in fact driven by an increasing number of parameters, and thus understanding its complexity has now become a cornerstone for defining future therapeutic strategies dealing with cancer progression and metastasis. A specificity of curcuminoids is their ability to target multiple molecular targets, modulate several signaling pathways, modify tumor microenvironments and enhance the host’s immune response. Although the effects of curcumin on these various parameters have been the subject of many reviews, the role of curcuminoids against EMT in the context of cancer have never been reviewed so far. This review first provides an updated overview of all EMT drivers, including signaling pathways, transcription factors, non-coding RNAs (ncRNAs) and tumor microenvironment components, with a special focus on the most recent findings. Secondly, for each of these drivers the effects of curcumin/curcuminoids on specific molecular targets are analyzed. Finally, we address some common findings observed between data reported in the literature and the results of investigations we conducted on experimental malignant mesothelioma, a model of invasive cancer representing a useful tool for studies on EMT and cancer.

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Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis

Cited by 29 publications

References 46 publications

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2

Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies

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