Curcumin attenuated acute Propionibacterium acnes -induced liver injury through inhibition of HMGB1 expression in mice

Gu, Qianqun; Guan, Huaijin; Shi, Qin; Zhang, Yanyun; Yang, Huilin

doi:10.1016/j.intimp.2014.12.005

Cited by 27 publications

(18 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HMGB1 is a highly conserved non-histone nuclear protein and constitutively expressed by nucleated cells and facilitates gene transcription, repair and recombination, and the biological activity of the HMGB1 depends on its location and post-translational modification [ 41 ]. Intracellular HMGB1 binds DNA and modulates chromosomal architecture; and once cells were activated and injured, HMGB1 can translocate outside of the cells [ 42 ]. Once released from the cell, HMGB1 binds to the transmembrane receptors, cytokines, and other exogenous molecules, and is known as one of the key endogenous damage-associated molecular pattern molecules and can trigger an array of inflammatory responses [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Grape Seed Proanthocyanidins Against Ccl4 Induced Acute Liver Injury in Mice

Zou

et al. 2016

Med Sci Monit

View full text Add to dashboard Cite

BackgroundWe investigated the effect of grape seed proanthocyanidins (GSPs) on carbon tetrachloride (CCl4)-induced acute liver injury.Material/MethodsSixty SPF KM mice were randomly divided into 6 groups: the control group, CCl4-model group, bifendate group (DDB group), and low-, moderate-, and high-dose GSP groups. The following parameters were measured: serum levels of alanine aminotransferase (ALT); aspartate aminotransferase (AST); tumor necrosis factor (TNF)-α; interleukin-6 (IL-6); high-mobility group box (HMGB)-1; body weight; liver, spleen, and thymus indexes; superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity; HMGB1 mRNA; malondialdehyde (MDA) content; hepatocyte proliferation; and changes in liver histology.ResultsCompared to the CCl4-model group, decreases in liver index and increases in thymus index significantly increased SOD and GSH-Px activities and reduced MDA content, and higher hepatocyte proliferative activity was found in all GSP dose groups and the DDB group (all P<0.001). Compared with the CCl4-model group, serum TNF-α and IL-6 levels and HMGB 1 mRNA and protein expressions decreased significantly in the high GSP dose group (all P<0.05).ConclusionsOur results provide strong evidence that administration of GSPs might confer significant protection against CCl4-induced acute liver injury in mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Role of Grape Seed Proanthocyanidins Against Ccl4 Induced Acute Liver Injury in Mice

Zou

et al. 2016

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…The activation of TLR4 signal pathway started from recognizing particular TLR ligands including LPS and LPS/TLR4 signaling, has been proved to be involved in endotoxemia induced multiple organ dysfunction40. The combination of TLR4 and MyD88 activates the downstream high-mobility group protein 1 (HMGB-1)414243.…”

Section: Discussionmentioning

confidence: 99%

Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism

Yang

Chen

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Sepsis, in addition to causing fatality, is an independent risk factor for cognitive impairment among sepsis survivors. The pathologic mechanism of endotoxemia induced acute neuro-inflammation still has not been fully understood. For the first time, we found the disruption of neurotransmitters 5-HT, impaired neurogenesis and activation of astrocytes coupled with concomitant neuro-inflammation were the potential pathogenesis of endotoxemia induced acute neuro-inflammation in sepsis survivors. In addition, dioscin a natural steroidal saponin isolated from Chinese medicinal herbs, enhanced the serotonergic system and produced anti-depressant effect by enhancing 5-HT levels in hippocampus. What is more, this finding was verified by metabolic analyses of hippocampus, indicating 5-HT related metabolic pathway was involved in the pathogenesis of endotoxemia induced acute neuro-inflammation. Moreover, neuro-inflammation and neurogenesis within hippocampus were indexed using quantitative immunofluorescence analysis of GFAP DCX and Ki67, as well as real-time RT-PCR analysis of some gene expression levels in hippocampus. Our in vivo and in vitro studies show dioscin protects hippocampus from endotoxemia induced cascade neuro-inflammation through neurotransmitter 5-HT and HMGB-1/TLR4 signaling pathway, which accounts for the dioscin therapeutic effect in behavioral tests. Therefore, the current findings suggest that dioscin could be a potential approach for the therapy of endotoxemia induced acute neuro-inflammation.

show abstract

“…Blood was centrifuged at 3000 rpm·min −1 for 10 min, and 200 µ L of the upper serum layer was collected to determine serum ALT and AST by using an Abbott automatic blood biochemical analyzer (Abbott Diagnostics, IL, USA). Serum HMGB1 and TGF- β 1 levels were evaluated by using specific enzyme-linked immunosorbent assay kits in accordance with the manufacturer's instructions [ 12 , 13 ]. In brief, 100 μ L serum and standard samples were added to duplicate wells and were incubated for 2 hours at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

Zhou

Zhang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI.

show abstract

Curcumin attenuated acute Propionibacterium acnes -induced liver injury through inhibition of HMGB1 expression in mice

Cited by 27 publications

References 62 publications

Protective Role of Grape Seed Proanthocyanidins Against Ccl4 Induced Acute Liver Injury in Mice

Protective Role of Grape Seed Proanthocyanidins Against Ccl4 Induced Acute Liver Injury in Mice

Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism

Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

Contact Info

Product

Resources

About