Curcumin as a promising antifungal of clinical interest

Martins, Cleide Viviane Buzanello; Silva, Danielle L. da; Neres, Ana Tereza M.; Magalhães, Thaís Furtado Ferreira; Watanabe, Gisele Almeida; Modolo, Luzia V.; Sabino, Adão A.; Fátima, Ângelo de; Resende, Maria Aparecida de

doi:10.1093/jac/dkn488

Cited by 229 publications

(141 citation statements)

References 7 publications

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“…Some previous investigations have already suggested that CUR per se may have antifungal properties [29,30] and its combination with light has been proposed in order to improve its antifungal action [23]. The results showed that the use of CUR in association with light was able to promote a significant antifungal effect against the planktonic form of the yeasts.…”

Section: Discussionmentioning

confidence: 87%

Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin

et al. 2011

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Background and ObjectiveThe resistance of Candida species to antifungals represents a major challenge for therapeutic and prophylactic strategies. This study evaluated photodynamic therapy (PDT) mediated by Curcumin (CUR) against clinical isolates of C. albicans, C. tropicalis, and C. glabrata, both in planktonic and biofilm forms.Study Design/Materials and MethodsSuspensions of Candida were treated with three CUR concentrations and exposed to four LED fluences. The protocol that showed the best outcomes for inactivation of the planktonic phase was selected to be evaluated against Candida biofilms. In addition, two higher CUR concentrations were tested. The metabolic activity of biofilms was evaluated by means of XTT reduction assay and the biofilm biomass was evaluated using crystal violet (CV) staining assay. Data were analyzed in a mixed model nested ANOVA, Wilcoxon's nonparametric tests, and the Kruskal–Wallis test (α = 5%).ResultsThe use of CUR in association with light was able to promote a significant antifungal effect against the planktonic form of the yeasts. When using 40 µM of CUR, the metabolic activity of C. albicans, C. glabrata, and C. tropicalis biofilms was reduced by 85%, 85%, and 73%, respectively, at 18 J/cm2. CUR‐mediated PDT also decreased the biofilm biomass of all species evaluated. In addition, CV staining showed that C. albicans isolates were strong biofilm‐forming strains, when compared with C. glabrata and C. tropicalis isolates.ConclusionThe results from the present investigation showed that low CUR concentrations can be highly effective for inactivating Candida isolates when associated with light excitation. Lasers Surg. Med. 43:927‐934, 2011. © 2011 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 87%

Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin

et al. 2011

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“…For instance, curcuminoids displayed activity to the HIV-1 protease and integrase enzymes (Vajragupta et al, 2005;Itokawa et al, 2008) and better antifungal activity than fluconazole against Paracoccidioides braziliensis and inhibited adhesion of Candida species to human epithelial cells (Martins et al, 2009). Isoxazole curcuminoids were highly active against mycobacterium tuberculosis (Changtam et al, 2010b).…”

Section: Introductionmentioning

confidence: 99%

Potent Trypanocidal Curcumin Analogs Bearing a Monoenone Linker Motif Act on Trypanosoma brucei by Forming an Adduct with Trypanothione

et al. 2014

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We have previously reported that curcumin analogs with a C 7 linker bearing a C 4 -C 5 olefinic linker with a single keto group at C3 (enone linker) display midnanomolar activity against the bloodstream form of Trypanosoma brucei. However, no clear indication of their mechanism of action or superior antiparasitic activity relative to analogs with the original di-ketone curcumin linker was apparent. To further investigate their utility as antiparasitic agents, we compare the cellular effects of curcumin and the enone linker lead compound 1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one (AS-HK014) here. An AS-HK014-resitant line, trypanosomes adapted to AS-HK014 (TA014), was developed by in vitro exposure to the drug. Metabolomic analysis revealed that exposure to AS-HK014, but not curcumin, rapidly depleted glutathione and trypanothione in the wild-type line, although almost all other metabolites were unchanged relative to control. In TA014 cells, thiol levels were similar to untreated wild-type cells and not significantly depleted by AS-HK014. Adducts of AS-HK014 with both glutathione and trypanothione were identified in AS-HK014-exposed wild-type cells and reproduced by chemical reaction. However, adduct accumulation in sensitive cells was much lower than in resistant cells. TA014 cells did not exhibit any changes in sequence or protein levels of glutathione synthetase and g-glutamylcysteine synthetase relative to wild-type cells. We conclude that monoenone curcuminoids have a different mode of action than curcumin, rapidly and specifically depleting thiol levels in trypanosomes by forming an adduct. This adduct may ultimately be responsible for the highly potent trypanocidal and antiparasitic activity of the monoenone curcuminoids.

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“…[131] However, curcumin showed more potent significant effect against Paracoccidioides brasiliensis than fluconazole, though it did not affect the growth of Aspergillus species. [132] …”

Section: Antifungal Effectmentioning

confidence: 99%

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Ashraf¹

2017

IJGP

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Curcuma longa Linn. is well-known and valued medicinal plant. It has a long history of traditional uses ranging from folk medicine to several culinary preparations. The phytochemical, pharmacological, and molecular studies of C. longa are reviewed. The rhizome is rich in essential oils, and various numbers of chemical constituents with biomedical significance have been isolated from it. The management of indigenous knowledge by appropriate documentation is recommended. This review was compiled to provide recent consolidated information covering different aspects of the plant, phytochemical, pharmacological, and molecular study to provide a basis on which to plan future studies and to promote sustainable use of C. longa.

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Curcumin as a promising antifungal of clinical interest

Cited by 229 publications

References 7 publications

Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin

Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin

Potent Trypanocidal Curcumin Analogs Bearing a Monoenone Linker Motif Act on Trypanosoma brucei by Forming an Adduct with Trypanothione

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