Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy

Dias, Lucas D.; Blanco, Kate Cristina; Mfouo-Tynga, Ivan; Inada, Natália Mayumi; Bagnato, Vanderlei Salvador

doi:10.1016/j.jphotochemrev.2020.100384

Cited by 131 publications

(87 citation statements)

References 248 publications

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“…This dual activity is reported as a significant advantage over currently used antibiotics (Konopka and Goslinski, 2007;Plotino et al, 2019), with effectiveness against antibiotic-sensitive and antibiotic-resistant microorganisms (Wainwright and Crossley, 2004). Furthermore, there is no evidence of bacterial resistance to the various metabolic pathways associated with the action of singlet oxygen or free radicals (Dias et al, 2020;Konopka and Goslinski, 2007).…”

Section: Pdtmentioning

confidence: 96%

“…Within dentistry, the application of PDT is expanding into different areas, such as treatment of head and neck cancer (Grant et al, 1993;Hopper, 2000), oral plaque biofilms (Tahmassebi et al, 2015;Wood et al, 2006), treatment of peri-implantitis www.ecmjournal.org (Bassetti et al, 2014;Bombeccari et al, 2013), and root canal disinfection (Asnaashari et al, 2017;Bonsor et al, 2006;de Miranda and Colombo, 2018;Soukos et al, 2006). More recently, PDT has been recommended as a positive adjunct in RET protocols (Deluca et al, 2021;Devaraj et al, 2016). However, to date, this is scarcely documented in vivo.…”

Section: Pdtmentioning

confidence: 99%

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What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies

Matoug‐Elwerfelli¹,

Nazzal²,

Duggal³

et al. 2021

eCM

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Regenerative/revitalisation endodontic techniques are increasingly used as a treatment approach for the management of immature permanent teeth with necrotic pulps. Different chemical irrigants and medicaments are routinely used clinically for intra-canal disinfection. However, despite remarkable progress in this field, coronal discolouration, cell cytotoxicity, difficulty of removal of organic biofilm from the root canal, development of sensitisation and antimicrobial resistance are still challenges to this line of treatment. This review critically discusses and challenges the current status quo of antimicrobials used in regenerative endodontics and sheds the light on future alternative antimicrobial materials with regenerative potential.

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Section: Pdtmentioning

confidence: 96%

Section: Pdtmentioning

confidence: 99%

What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies

Matoug‐Elwerfelli¹,

Nazzal²,

Duggal³

et al. 2021

eCM

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“…The use of curcumin, a natural PS extracted from the rhizomes of Curcuma longa plant, represents an ecologically positive alternative for vector control, since this molecule is already present in nature and can be easily degraded, being less harmful to the environment and non‐target organisms 17–19 . Some studies also showed that extracts and essential oils from Curcuma longa have larvicidal and repellent activity, 20,21 as well as isolated curcuminoids 22 .…”

Section: Introductionmentioning

confidence: 99%

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Mezzacappo

Souza

Inada

et al. 2021

Pest Management Science

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BACKGROUND Resistant populations of Ae. aegypti have been a major problem in arboviruses epidemic areas, generating a strong demand for novel methods of vector control. In this regard, our group has demonstrated the use of curcumin as an efficient photoactive larvicide to eliminate Ae. aegypti larvae. This work was aimed to evaluate the Ae. aegypti (Rockefeller) development under sublethal conditions, using a curcumin/d‐mannitol (DMC) formulation. The photolarvicidal efficacy under semi‐field and field conditions (wild populations) was also analyzed, as well as the photobleaching and residual activity of DMC. RESULTS A delay in development time when larvae were exposed to sublethal concentrations of DMC was observed, followed by significant changes in sex ratio and reduction in longevity. DMC also presented a low residual activity when compared to usual larvicides, and had a substantial photolarvicidal activity against wild populations in field trials, achieving 71.3% mortality after 48 h. CONCLUSIONS Overall, these findings are of great biological importance for the process of enabling the implementation of DMC as a new product in the control of Ae. aegypti larvae, and contributes to the improvement of new plant‐based larvicides. © 2021 Society of Chemical Industry

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“…Based on the literature evidence, the energy transfer mechanism between the UCNP and nanocurcumin for photodynamic therapy (PDT) applications could be explained [ 46 ]. It is well known that curcumin is not only used as a natural drug to treat various diseases, but it also used as a photosensitizer for PDT [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies

et al. 2021

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Formulation of promising anticancer herbal drug curcumin as a nanoscale-sized curcumin (nanocurcumin) improved its delivery to cells and organisms both in vitro and in vivo. We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) to endow visualisation in the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) and NaYF4:Yb,Tm (UCNP2) nanoparticles were synthesised by reverse microemulsion method and then functionalized it with PLGA to form UCNP-PLGA nanocarrier followed up by loading with the solvent-antisolvent process synthesized herbal nanocurcumin. The UCNP samples were extensively characterised with XRD, Raman, FTIR, DSC, TGA, UV-VIS-NIR spectrophotometer, Upconversion spectrofluorometer, HRSEM, EDAX and Zeta Potential analyses. UCNP1-PLGA-nanocurcumin exhibited emission at 520, 540, 660 nm and UCNP2-PLGA-nanocurmin showed emission at 480 and 800 nm spectral bands. UCNP-PLGA-nanocurcumin incubated with rat glioblastoma cells demonstrated moderate cytotoxicity, 60–80% cell viability at 0.12–0.02 mg/mL marginally suitable for therapeutic applications. The cytotoxicity of UCNPs evaluated in tumour spheroids models confirmed UCNP-PLGA-nanocurcumin therapeutic potential. As-synthesised curcumin-loaded nanocomplexes were administered in tumour-bearing laboratory animals (Lewis lung cancer model) and showed adequate contrast to enable in vivo and ex vivo study of UCNP-PLGA-nanocurcumin bio distribution in organs, with dominant distribution in the liver and lungs. Our studies demonstrate promise of nanocurcumin-loaded upconversion nanoparticles for theranostics applications.

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Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy

Cited by 131 publications

References 248 publications

What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies

What the future holds for regenerative endodontics: novel antimicrobials and regenerative strategies

Curcumin/d‐mannitol as photolarvicide: induced delay in larval development time, changes in sex ratio and reduced longevity of Aedes aegypti

Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies

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