Curcumin as a Novel Nanocarrier System for Doxorubicin Delivery to MDR Cancer Cells: In Vitro and In Vivo Evaluation

Rejinold, N. Sanoj; Yoo, Jisang; Jon, Sangyong; Kim, Yeu‐Chun

doi:10.1021/acsami.8b10426

Cited by 32 publications

(20 citation statements)

References 55 publications

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“…As aforementioned, co-administration of procyanidin, scillarenin, polmoric acid, betulinic acid, and a high dose of QUE could enhance the efficacy of anticancer agents against brain cancer by inhibiting efflux transporters in the BBB. A recent study reported that curcumin nanoparticles loaded with DOX could more efficiently deliver and localize DOX into P-gp-and MRP-overexpressed cancer cells (e.g., glioblastoma) by inhibiting those efflux transporters, thereby enhancing the anticancer efficacy in the tumor-xenograft model compared to the treatment of DOX solution, while this synergistic effect is the most remarkably exhibited in the treatment of polyethylene glycol-conjugated curcumin nanoparticles loaded with DOX [103].…”

Section: Combinatorial Therapies Of Natural Compound and Drug For Synmentioning

confidence: 99%

Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

Khadka

Lee

Park

et al. 2021

IJMS

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Natural compounds such as herbal medicines and/or phyto-compounds from foods, have frequently been used to exert synergistic therapeutic effects with anti-brain disorder drugs, supplement the effects of nutrients, and boost the immune system. However, co-administration of natural compounds with the drugs can cause synergistic toxicity or impeditive drug interactions due to changes in pharmacokinetic properties (e.g., absorption, metabolism, and excretion) and various drug transporters, particularly brain transporters. In this review, natural compound–drug interactions (NDIs), which can occur during the treatment of brain disorders, are emphasized from the perspective of pharmacokinetics and cellular transport. In addition, the challenges emanating from NDIs and recent approaches are discussed.

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Section: Combinatorial Therapies Of Natural Compound and Drug For Synmentioning

confidence: 99%

Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

Khadka

Lee

Park

et al. 2021

IJMS

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“…However, the average diameter of PEG-b-PAsp-g-PBE/DOX was determined as 95 nm by TEM ( Figure 4) and DLS ( Figure S7), which increase with the effect of the dox encapsulation. Their, surface charges vary from À23.9 mV to À16.1 mV, demonstrating that DOX has been loaded through the electrostatic interaction (Rejinold et al, 2018).…”

Section: Preparation Of Polymeric Micelles and Drug Release In Vitromentioning

confidence: 99%

Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

Wang

Zhang

et al. 2020

Drug Delivery

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Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered by intracellular stimuli, as well as reduced cytotoxicity. We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Phenylboronic Ester) group grafted, which can achieve fast response to intracellular ROS and enhanced anti-tumor activity. With this, PEG-b-PAsp-g-PBE/DOX system showed better tumor growth inhibition when studied on HeLa cell lines with high level of intracellular ROS and its subcutaneous tumor models. Additionally, the administration of PEG-b-PAsp-g-PBE/DOX did cause significantly lower systemic toxicity in comparison with free DOX. Hence, PEG-b-PAsp-g-PBE could be a highly efficient and safe nanocarrier to improve the efficacy of chemotherapeutic.

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“…One of the advantages of using nanocarriers to codeliver chemotherapy drugs and active constituents of plants is their capability to reverse MDR [32,91,148](seen Figure 2). Rejinold et al [88] investigated using CUR as the nanocarrier to load PEG-doxorubicin hydrochloride for HCT-8/DOX-resistant cells to increase the in vivo and in vitro antitumor efficacy. In vitro anti-MDR experiments have shown that PEG CRC/DOX NPs had a higher antimetastatic and antiproliferative effect on MDR cancer cells while normal fibroblasts were unaffected.…”

Section: Multidrugmentioning

confidence: 99%

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

Xiong

et al. 2019

BioMed Research International

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Antitumor therapy using a combination of drugs has shown increased clinical efficacy. Active constituents derived from plants can offer several advantages, such as high efficiacy, low toxicity, extensive effects, and multiple targets. At present, the combination of plants’ active constituents and chemotherapeutic drugs has attracted increased attention. Nanodrug delivery systems (NDDSs) have been widely used in tumor-targeted therapy because of their efficacy of delivering antitumor drugs. The in vivo process of tumor-targeted NDDSs has several steps. They include blood circulation, tumor accumulation and penetration, target cell internalization and uptake, and drug release and drug response. In each step, NDDSs encounter multiple barriers that prevent their effective delivery to target sites. Studies have been performed to find alternative strategies to overcome these barriers. We reviewed the recent progress of codelivery of active constituents of plants and chemotherapeutics using NDDSs. Progress into transversing the physiological barriers for more effective in vivo antitumor delivery will be discussed in this review.

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Curcumin as a Novel Nanocarrier System for Doxorubicin Delivery to MDR Cancer Cells: In Vitro and In Vivo Evaluation

Cited by 32 publications

References 55 publications

Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

Impacts of Drug Interactions on Pharmacokinetics and the Brain Transporters: A Recent Review of Natural Compound-Drug Interactions in Brain Disorders

Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell

The Application of Nanotechnology in the Codelivery of Active Constituents of Plants and Chemotherapeutics for Overcoming Physiological Barriers during Antitumor Treatment

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