Curcumin as a Natural Approach of Periodontal Adjunctive Treatment and Its Immunological Implications: A Narrative Review

Solomon, Sorina Mihaela; Stafie, Celina Silvia; Șufaru, Irina-Georgeta; Teslaru, Silvia; Ghiciuc, Cristina Mihaela; Petrariu, F.D.; Țănculescu, Oana

doi:10.3390/pharmaceutics14050982

Cited by 8 publications

(8 citation statements)

References 102 publications

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“…Phytotherapeutic products, such as propolis [46] or turmeric [47], have also been addressed in the development of gels with subgingival application. Dave et al observed significant reductions in plaque index, bleeding on probing, probing depth and periodontal clinical attachment loss after turmeric gel [48].…”

Section: Gelsmentioning

confidence: 99%

“…The use of aPDT in adjunctive periodontal therapy can be amplified by applying a photosensitizing substance in the periodontal pocket and irradiating it with a light source (laser or LED) of a wavelength appropriate to the used substance [47,80]; cytotoxic reactive oxygen species are generated after exposure to light, with effects involving protein, cell membrane and bacterial organ damage [81] (Figure 2).…”

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

“…A photosensitizer or photoactivatable agent, such as methylene blue, is applied in the periodontal pocket. Exposure of tissue to light at the appropriate wavelength in the presence of molecular oxygen generates the formation of reactive oxygen species (ROS); ROS causes non-thermal cytotoxic effects by damaging microorganisms' proteins, cell membranes and organelles [47,82].…”

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

“…Various photosensitizing agents have been investigated in periodontal therapy, including phenothiazine derivatives (methylene blue, toluidine blue), xanthens (erythrosine, eosin-Y, Bengal roses), riboflavin derivatives, indocyanine green, fullerene derivatives, bordipiromethane [47,83].…”

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

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Advances in Locally Delivered Antimicrobials for Periodontitis Treatment

Șufaru¹,

Mârțu²,

Luchian³

et al. 2023

Periodontology - New Insights

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Periodontal disease represents an inflammatory disease of the tissues supporting the maintenance and functionality of the teeth on the dental arches. The main cause of periodontitis consists in periodontal dysbiosis, which will trigger an inflammatory response, progressively leading to periodontal tissue breakdown. Scaling and root planing represent the gold standard in treating periodontal diseases but, as it was already established, these measures are unable to completely eliminate the subgingival bacterial plaque. Therefore, new adjunctive therapies have emerged, involving systemic and local delivery of various antimicrobial products. This chapter aims to provide current knowledge on the local application of different periodontal supplementary therapies. The chapter focuses on local forms of antimicrobials, such as irrigations, gels or controlled release systems but also on laser/LED-assisted periodontal pocket photodynamic antibacterial therapy (PDT), along with various photosensitizers. Moreover, we present data from current guidelines regarding the recommendations for the main locally delivered antimicrobials.

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Section: Gelsmentioning

confidence: 99%

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

Section: Photodynamic Antibacterial Therapymentioning

confidence: 99%

See 2 more Smart Citations

Advances in Locally Delivered Antimicrobials for Periodontitis Treatment

Șufaru¹,

Mârțu²,

Luchian³

et al. 2023

Periodontology - New Insights

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“…Curcumin, as a main bioactive polyphenolic compound, is extracted from the curcuma longa (also known as tumeric) that is a plant belonging to the ginger family (Zingiberaceae), originated from India, and currently grown in Southeast Asia and China [ 15 ]. Curcuma has attracted broad attention from ancient times as it owns profound biochemical and biological activities, such as antiviral, antimicrobial, anti-inflammatory, and antioxidant activities [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis

Peng

Jiang

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Oral submucous fibrosis (OSMF) is a chronic, fibrotic disease that affects the oral cavity, showing a high rate of malignant transformation. Curcuma exerts therapeutic potentials in many diseases including OSMF. However, the potential targets and pathways to explain the therapeutic effects of curcuma on OSMF are outside the scope of present knowledge. Herein we intend to reveal the predictive targets and potential pathways of curcuma against OSMF by a network pharmacology-based approach followed by molecular docking technology. Methods. We searched the SymMap, GeneCards, and OMIM database to obtain curcuma and OSMF common targets. The protein-protein interaction (PPI) of curcuma and OSMF common targets were then analyzed, followed by functional enrichment analysis. The best binding mode of curcuma and target proteins was analyzed by molecular docking technology. Results. We collected 290 putative targets of curcuma molecules and 600 known therapeutic targets of OSMF, with 64 curcuma and OSMF common targets sorted out. In the PPI network, there were 63 nodes with 922 edges. The node indicates protein and the line indicates PPI relation. The most enriched GO term in the BP level is “gland development”, followed by “cellular response to chemical stress”, and then “response to oxygen levels”, while the most enriched GO term in CC and MF is “membrane raft” and “cytokine receptor binding”, respectively. We also found 131 KEGG pathways significantly enriched by curcuma and OSMF common targets. The binding energy of curcuma to ALB, TNF, TP53, IL6, and VEGFA was −9.5 kcal/mol, −3.9 kcal/mol, −3.5 kcal/mol, −3.6 kcal/mol, and −8.9 kcal/mol, respectively, which suggested ALB and VEGFA were regarded as main targets involving in the potential mechanism of curcuma against OSMF. Conclusion. The present study illustrated that the therapeutic effects of curcuma on OSMF were achieved by targeting ALB and VEGFA, which giving reference to further drug design and development for OSMF.

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Advances in novel therapeutic approaches for periodontal diseases

et al. 2022

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Periodontal diseases are pathological processes resulting from infections and inflammation affecting the periodontium or the tissue surrounding and supporting the teeth. Pathogenic bacteria living in complex biofilms initiate and perpetuate this disease in susceptible hosts. In some cases, broad-spectrum antibiotic therapy has been a treatment of choice to control bacterial infection. However, increasing antibiotic resistance among periodontal pathogens has become a significant challenge when treating periodontal diseases. Thanks to the improved understanding of the pathogenesis of periodontal disease, which involves the host immune response, and the importance of the human microbiome, the primary goal of periodontal therapy has shifted, in recent years, to the restoration of homeostasis in oral microbiota and its harmonious balance with the host periodontal tissues. This shift in therapeutic goals and the drug resistance challenge call for alternative approaches to antibiotic therapy that indiscriminately eliminate harmful or beneficial bacteria. In this review, we summarize the recent advancement of alternative methods and new compounds that offer promising potential for the treatment and prevention of periodontal disease. Agents that target biofilm formation, bacterial quorum-sensing systems and other virulence factors have been reviewed. New and exciting microbiome approaches, such as oral microbiota replacement therapy and probiotic therapy for periodontal disease, are also discussed.

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Curcumin as a Natural Approach of Periodontal Adjunctive Treatment and Its Immunological Implications: A Narrative Review

Cited by 8 publications

References 102 publications

Advances in Locally Delivered Antimicrobials for Periodontitis Treatment

Advances in Locally Delivered Antimicrobials for Periodontitis Treatment

Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis

Advances in novel therapeutic approaches for periodontal diseases

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