Curcumin as a MicroRNA Regulator in Cancer: A Review

Momtazi, Amir Abbas; Shahabipour, Fahimeh; Khatibi, Sepideh; Johnston, Thomas P.; Pirro, Matteo; Sahebkar, Amirhossein

doi:10.1007/112_2016_3

Cited by 200 publications

(130 citation statements)

References 111 publications

Supporting

Mentioning

130

Contrasting

Order By: Relevance

“…MiRNAs employed several cellular and molecular targets such as PTEN, p53, Bcl‐2, MAPK, and Akt for exerting their effects (Keshavarzi, Darijani, et al, ; Keshavarzi, Sorayayi, et al, ; Mohammadi, Goodarzi, Jaafari, Mirzaei, & Mirzaei, ; Reza Mirzaei et al, ). Several studies indicated that curcumin could exert anti‐cancer properties via targeting miRNAs (Momtazi et al, ; Zhou et al, ). These studies revealed that curcumin could affect various miRNAs such as miR34a, miR‐21, miR‐181, miR‐7, and miR‐9 and miR‐200c (Momtazi et al, ; Zhou et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies indicated that curcumin could exert anti‐cancer properties via targeting miRNAs (Momtazi et al, ; Zhou et al, ). These studies revealed that curcumin could affect various miRNAs such as miR34a, miR‐21, miR‐181, miR‐7, and miR‐9 and miR‐200c (Momtazi et al, ; Zhou et al, ). Moreover, it has been shown that curcumin could affect the sensitivity to chemotherapy via targeting a variety of miRNAs such as miR‐186, miR‐21, and miR‐27a.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNA: A novel target of curcumin in cancer therapy

Mirzaei

Masoudifar

Sahebkar

et al. 2017

Journal Cellular Physiology

Self Cite

213

180

View full text Add to dashboard Cite

Curcumin is known as a natural dietary polyphenol which is extracted from Curcuma longa L. It has been shown that curcumin has a variety of pharmacological effects such as antioxidant, anti-cancer, anti-inflammatory, and anti-microbial activities. Anti-cancer effects of curcumin are due to targeting of a wide range of cellular and molecular pathways involved in cancer pathogenesis including NF-kB, MAPK, PTEN, P53, and microRNAs (miRNA) network. Multiple lines of evidence have indicated that curcumin exerts its therapeutic effects via regulating miRNA expression (e.g., miR-1, miR-7, miR-9, miR-34a, miR-181, miR-21, and miR-19) which could lead to the regulation of underlying cellular and molecular pathways involved in cancer pathogenesis. Exosomes are one of the important classes of biological vehicles which could be released from various types of cells such as cancer cells and stem cells and could change the behavior of recipient cells. It has been shown that treatment of cancer cells with different dose of curcumin leads to the release of exosomes containing curcumin. These exosomes could induce anti-cancer properties in recipient cells and reduce tumor growth. Hence, exosomes containing curcumin could be applied as powerful tools for cancer treatment. Here, we highlighted various miRNAs which could be affected by curcumin in various types of cancer. Moreover, we highlight exosomes containing curcumin as suitable therapeutic tools in cancer therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA: A novel target of curcumin in cancer therapy

Mirzaei

Masoudifar

Sahebkar

et al. 2017

Journal Cellular Physiology

Self Cite

213

180

View full text Add to dashboard Cite

show abstract

“…Mechanistically, curcumin has been shown to regulate multiple targets including NF-κB, Akt, Notch, mTOR, and Hh 23–25. Recently, a growing body of evidence has implicated curcumin in regulating the expression of multiple miRNAs 26. Curcumin regulated miR-138 expression, leading to inhibition of cell proliferation and invasion in human osteosarcoma cells 27.…”

Section: Introductionmentioning

confidence: 99%

Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells

Feng¹,

Wang²,

Zhang³

et al. 2017

OTT

View full text Add to dashboard Cite

Curcumin, a natural polyphenol compound, exhibits tumor suppressive activity in a wide spectrum of cancers, including nasopharyngeal carcinoma cells. However, the exact molecular mechanisms governing this tumor suppressive activity remain elusive. Multiple studies have revealed that miRNAs are critically involved in tumorigenesis, indicating that targeting miRNAs could be a therapeutic strategy for treating human cancer. In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells. We found that curcumin inhibited cell growth, induced apoptosis, retarded cell migration and invasion, and triggered cell cycle arrest in the human nasopharyngeal carcinoma cell lines CNE1 and CNE2. Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target. Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients.

show abstract

“…67 The ALDH1 expression is found to be increased in CSCs in inflammatory breast cancer. 66,76 CDF was reported to inhibit EZH2, Notch-1, CD44, EpCAM, and Nanog expression of CSCs in pancreatic cancer cells such as AsPC-1 and MiaPaCa-2 cells. Overexpression of CD133 has been frequently revealed in CSCs.…”

Section: On Csc Markersmentioning

confidence: 99%

“…103 In contrast, Subramaniam et al, 104 Zhou et al, 105 and Abdel Aziz et al 106 109,110 By affecting signaling pathways and CSC signature genes, miRNAs are also able to regulate CSC characteristics. 76,77,104,112,113 It has reported that miRNAs play pivotal roles in mediating inhibitory effects of curcumin on CSCs selfrenewal capacity, tumorigenic ability, and sphere formation. 76,77,104,112,113 It has reported that miRNAs play pivotal roles in mediating inhibitory effects of curcumin on CSCs selfrenewal capacity, tumorigenic ability, and sphere formation.…”

Section: The Effects Of Curcumin On Cscs Mediated By Modulation Of mentioning

confidence: 99%

The molecular mechanisms of curcumin’s inhibitory effects on cancer stem cells

Zendehdel

Abdollahi

Momtazi‐Borojeni

et al. 2018

J of Cellular Biochemistry

Self Cite

View full text Add to dashboard Cite

Curcumin is a dietary polyphenol and a bioactive phytochemical that possesses anti‐inflammatory, antioxidant, anticancer, and chemopreventive properties, which make it capable of affecting multiple sites along the stem cell pathways to induce apoptosis in these cells. Curcumin’s function is through suppression of cytokine release, especially the secretion of interleukins. Some of the predominant activities of stem cells include regeneration of identical cells and the ability to maintain the proliferation and multipotentiality. However, these cells could be stimulated to differentiate into specific cell types, leading to the development of tumors. Cancer stem cells (CSC) are capable of sustaining tumor formation and differentiation, and are normally characterized by self‐renewal mechanisms. Furthermore, these cells might be responsible for tumor relapse and resistance to therapy. Several studies have focused on the mechanisms of curcumin action in manipulating transcription factors, signaling pathways, CSC markers, microRNAs related to CSCs functions and apoptosis induction in various human cancer cells. In the present review, we aimed to summarize the reported molecular mechanisms of curcumin’s effects on CSCs.

show abstract

Curcumin as a MicroRNA Regulator in Cancer: A Review

Cited by 200 publications

References 111 publications

MicroRNA: A novel target of curcumin in cancer therapy

MicroRNA: A novel target of curcumin in cancer therapy

Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells

The molecular mechanisms of curcumin’s inhibitory effects on cancer stem cells

Contact Info

Product

Resources

About