Curcumin and whey protein concentrate binding: Thermodynamic and structural approach

Rácz, Csaba-Pal; Racz, Levente Zsolt; Floare, Călin G.; Tomoaia, Gheorghe; Horovitz, Ossi; Riga, Sorin; Kacsó, Irina; Borodi, Gheorghe; Sárközi, Melinda; Mocanu, Aurora; Roman, Cecilia; Tomoaia-Cotişel, Maria

doi:10.1016/j.foodhyd.2023.108547

Cited by 11 publications

(11 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was one binding site for Cur on MC or WP (Table 2). Similar findings were reported for curcuminoids and buttermilk proteins (Fu et al., 2014) and for Cur and WP concentrate (Racz et al., 2023), but 0.9 for Cur–bovine serum albumin (Hudson et al., 2017).…”

Section: Resultssupporting

confidence: 81%

“…There was one binding site for Cur on MC or WP (Table 2). Similar findings were reported for curcuminoids and buttermilk proteins (Fu et al, 2014) and for Cur and WP concentrate (Racz et al, 2023), but 0.9 for Cur-bovine serum albumin (Hudson et al, 2017). TA B L E 1 Correlation coefficients, quenching constants (K sv ), and quenching rate constants (K q ) of the interaction between curcumin (Cur) and micellar casein (MC) or whey protein (WP).…”

Section: Binding Constants Of Cur To Wp and MCsupporting

confidence: 73%

“…The variation in Δ G for the binding of Cur and MC or WP was always negative, so the binding was thermodynamically spontaneous. The Δ G values were around −30 kJ mol −1 for Cur–WP but −33 kJ mol −1 for Cur–MC, indicating a slightly higher stability for Cur–MC (Racz et al., 2023).…”

Section: Resultsmentioning

confidence: 99%

“…The high hydrophilic properties of WP make it a good candidate for loading Cur. For instance, WP concentrate and Cur formed a complex through hydrophobic interactions, which had the highest stability at pH 1.5 (Racz et al., 2023). Furthermore, to greatly promote Cur properties, particles and gels were fabricated using WP and other natural biomacromolecules.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interaction between curcumin and ultrafiltered casein micelles or whey protein, and characteristics of their complexes

Wu,

Qin,

et al. 2024

Journal of Food Science

View full text Add to dashboard Cite

This work evaluated the interaction between micellar casein (MC) or whey protein (WP) in ultrafiltration retentate with curcumin (Cur), as well as the physicochemical and functional properties of Cur–MC and Cur–WP complexes. The MC had a higher affinity for Cur than WP, shown by higher binding constants of Cur–MC at various temperatures. Thermodynamic analysis of the binding process indicated that the interaction between Cur and MC or WP was hydrophobic in nature. Cur promoted the size and polydispersity index of MC and WP at 4 mM but did not alter the morphology of spray‐dried MC and WP. The Cur–MC complexes showed better aqueous solubility at pH 2–3 and 6–10 compared to free MC. Combination with MC or WP improved the 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonate) radical scavenging activity of Cur. In addition, combination with MC and WP promoted cumulative release of Cur during simulated gastrointestinal digestion, especially for WP. Thus, MC and WP in retentates can be good alternative protein‐based carriers for Cur delivery, whereas their complexes in powder form have good functional properties that could be used as active food ingredients in several food formulations.Practical ApplicationMicrofiltration is a cheap and convenient approach that can be used to easily produce micellar casein (MC), with whey protein (WP) as one byproduct. In this study, we proved that MC and WP in retentates have strong interaction with curcumin (Cur), whereas their complexes have good functional properties. Thus, spray‐dried MC–Cur or WP–Cur complexes could be used as active food ingredients in several food formulations.

show abstract

Section: Resultssupporting

confidence: 81%

Section: Binding Constants Of Cur To Wp and MCsupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interaction between curcumin and ultrafiltered casein micelles or whey protein, and characteristics of their complexes

Wu,

Qin,

et al. 2024

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…Also, it is known to induce apoptosis in prostate cancer cells but also to prevent the progression of this cancer [3]. This proactive compound can form innovative composites and complexes with applications in medicine and in this sense facilitates the understanding of the mechanisms of action during application [4][5][6][7][8][9].…”

Section: Fig 1 Bioactive Compounds From Plantsmentioning

confidence: 99%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

View full text Add to dashboard Cite

This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

show abstract

Development of novel EGCG/Fe loaded sodium alginate-based packaging films with antibacterial and slow-release properties

et al. 2023

View full text Add to dashboard Cite

Curcumin and whey protein concentrate binding: Thermodynamic and structural approach

Cited by 11 publications

References 92 publications

Interaction between curcumin and ultrafiltered casein micelles or whey protein, and characteristics of their complexes

Interaction between curcumin and ultrafiltered casein micelles or whey protein, and characteristics of their complexes

Interaction of Bioactive Compounds With Ceramic Materials – A Review

Development of novel EGCG/Fe loaded sodium alginate-based packaging films with antibacterial and slow-release properties

Contact Info

Product

Resources

About