Curcumin and tetrahydrocurcumin induce cell death in Ara‐C‐resistant acute myeloid leukemia

Tseng, Yu‐Hsin; Chiou, Shyh‐Shin; Weng, Jui‐Pei; Lin, Pei‐Chin

doi:10.1002/ptr.6316

Cited by 28 publications

(21 citation statements)

References 42 publications

(53 reference statements)

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“…In addition, study found that caspase-3 activity and B-cell lymphoma 2-associated X protein levels were suppressed by THC (Xi et al, 2019). In human myelogenous leukemia, research showed that cell deaths in Ara-Cresistant HL60 cells were induced by THC through autophagy (Tseng, Chiou, Weng, & Lin, 2019). and vinblastine alone were 0.9 ± 0.5 μM, 0.7 ± 0.2 μM and 1.1 ± 0.3 μM, respectively.…”

Section: Modification Of Seven Carbon Chainmentioning

confidence: 95%

“…In addition, study found that caspase‐3 activity and B‐cell lymphoma 2‐associated X protein levels were suppressed by THC (Xi et al, 2019). In human myelogenous leukemia, research showed that cell deaths in Ara‐C‐resistant HL60 cells were induced by THC through autophagy (Tseng, Chiou, Weng, & Lin, 2019). And in squamous cell carcinoma of esophagus, the THC reversed MDR of chemoresistant ESCC (TE‐1 cells resisted to 5‐FU) by the suppression of CSCs and regulating apoptosis (Pendleton Emily et al, 2019).…”

Section: Application Of Cur Derivative In Tumor Mdrmentioning

confidence: 99%

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Application of curcumin and its derivatives in tumor multidrug resistance

Guo

et al. 2020

Phytotherapy Research

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Malignant tumor endangers seriously the health of all mankind. Multidrug resistance (MDR) is one of the main causes of clinical tumor chemotherapy failure. Curcumin (CUR) has not only antitumor activity but also reversing tumor MDR effect. CUR reverses tumor MDR via regulating related signal pathways or corresponding expressed proteins or gene. When combined with chemotherapeutic agents, CUR can be a chemotherapeutic sensitive agent to enhance chemotherapy efficacy and weaken tumor MDR. On the other hand, to improve the MDR reversal effect of CUR, its derivatives have been extensively studied. Therefore, this article mainly focuses on reviewing the application of CUR and its derivatives in MDR and its mechanism of reversing MDR.

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Section: Modification Of Seven Carbon Chainmentioning

confidence: 95%

Section: Application Of Cur Derivative In Tumor Mdrmentioning

confidence: 99%

Application of curcumin and its derivatives in tumor multidrug resistance

Guo

et al. 2020

Phytotherapy Research

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“…They also showed that tetrahydrocurcumin triggered autophagy in HL-60 cells by impairing PI3K/Akt and mTOR/p70S6K signaling [ 80 ]. In cytarabine chemotherapy-resistant HL-60 cells, tetrahydrocurcumin induced autophagy by upregulating p62 and LC3, whereas curcumin caused apoptosis via activation of caspases [ 81 ]. This information suggests a novel therapeutic application of tetrahydrocurcumin for overcoming drug resistance in cancers.…”

Section: Anti-cancer Effects and The Underlying Mechanisms Of Tetrmentioning

confidence: 99%

The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin

Lai

Pan

2020

Biomolecules

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In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action.

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“…It has been reported that curcumin or the metabolite tetrahydrocurcumin induced cell death in chemotherapy-resistant (Ara-C) human AML cells (HL-60) with two different modalities. In fact, curcumin mainly activated apoptotic cell death, through the regulation of poly(ADP-ribose) polymerase (PARP), caspase-9 and caspase-3, while tetrahydrocurcumin mainly induced autophagy by increasing both LC3 and p62 [231]. Tetrahydrocurcumin (10-130 µM) was also employed in human NSCLC A549 cells.…”

Section: Curcuminoidsmentioning

confidence: 99%

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

Benvenuto

Albonici

Focaccetti

et al. 2020

IJMS

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One of the hallmarks of cellular transformation is the altered mechanism of cell death. There are three main types of cell death, characterized by different morphological and biochemical features, namely apoptosis (type I), autophagic cell death (type II) and necrosis (type III). Autophagy, or self-eating, is a tightly regulated process involved in stress responses, and it is a lysosomal degradation process. The role of autophagy in cancer is controversial and has been associated with both the induction and the inhibition of tumor growth. Autophagy can exert tumor suppression through the degradation of oncogenic proteins, suppression of inflammation, chronic tissue damage and ultimately by preventing mutations and genetic instability. On the other hand, tumor cells activate autophagy for survival in cellular stress conditions. Thus, autophagy modulation could represent a promising therapeutic strategy for cancer. Several studies have shown that polyphenols, natural compounds found in foods and beverages of plant origin, can efficiently modulate autophagy in several types of cancer. In this review, we summarize the current knowledge on the effects of polyphenols on autophagy, highlighting the conceptual benefits or drawbacks and subtle cell-specific effects of polyphenols for envisioning future therapies employing polyphenols as chemoadjuvants.

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Curcumin and tetrahydrocurcumin induce cell death in Ara‐C‐resistant acute myeloid leukemia

Cited by 28 publications

References 42 publications

Application of curcumin and its derivatives in tumor multidrug resistance

Application of curcumin and its derivatives in tumor multidrug resistance

The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

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