Curcumin and Nanocurcumin Oral Supplementation Improve Muscle Healing in a Rat Model of Surgical Muscle Laceration

Kazemi‐Darabadi, Siamak; Nayebzadeh, Ramin; Shahbazfar, Amir Ali; Kazemi-Darabadi, Faranak; Fathi, Ezzatollah

doi:10.29252/beat-0703013

Cited by 11 publications

(6 citation statements)

References 36 publications

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“…The present morphometric measurements showed that the treatment with chitosan and curcumin nanoparticles significantly enhanced muscle regeneration which was evidenced by the increased average myotube diameter and shifting in the distribution of myotube diameters towards larger values. This result agrees with the previous result showing significantly higher muscle fibers regeneration in nano curcumin-supplemented animals than the control group following surgical muscle laceration injury [ 52 ].…”

Section: Discussionsupporting

confidence: 93%

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Effect of chitosan and curcumin nanoparticles against skeletal muscle fibrosis at early regenerative stage of glycerol-injured rat muscles

Mahdy

Akl

Madkour

2022

BMC Musculoskelet Disord

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Introduction Chitosan and curcumin are natural products that have a wide range of beneficial effects including wound healing. However, their high molecular weight and poor water solubility limit their applications. Aims Therefore, the current study aims to evaluate the effects of chitosan (Cs) and curcumin (Cn) nanoparticles (NPs) on fibrosis and regeneration of glycerol-injured muscle. Methods Muscle injury was induced by intramuscular injection of glycerol into the tibialis anterior muscle of rats. Cs-NPs and Cn-NPs were administered at different doses intraperitoneally after injury. Injured muscles were collected at day 7 after injury, and muscle fibrosis and regeneration were assessed. Results The present results revealed that Cs-NPs and Cn-NPs treatment significantly decreased fibrosis index and increased the average myotube diameter with shifting of the distribution of myotube diameters towards larger diameters in a dose-dependent manner. Immunohistochemical analysis revealed that Cs-NPs and Cn-NPs treatment significantly decreased the number of CD-68+ cells and Col-1+ area. Results showed that Cn-NPs had a higher protective effect, in the form of attenuating muscle fibrosis and inflammation, and enhancing muscle regeneration, than that of Cs-NPs. Conclusions To our knowledge, this is the first study to document the effects of Cs-NPs in injured muscles. The results of study might be a novel approach to attenuate muscle fibrosis in humans using curcumin and chitosan nanoparticles.

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Section: Discussionsupporting

confidence: 93%

“…These results further support the present finding showing a significant reduction in the number of CD-68 + cells following treatment with chitosan and curcumin nanoparticles. In addition, nano curcumin supplementation significantly decreased muscle fibrosis following surgical muscle laceration injury [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of chitosan and curcumin nanoparticles against skeletal muscle fibrosis at early regenerative stage of glycerol-injured rat muscles

Mahdy

Akl

Madkour

2022

BMC Musculoskelet Disord

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“…As in the MBGN case, these peaks may be overlapped by the spectra of PHBV. However, the band around 3400 cm −1 , due to the stretching of hydrogen bonded -OH groups present in curcumin, was clearly observed [ 31 , 32 , 33 ]. Due to the fact that no new functional groups in the FTIR spectrum were detected, it is possible to consider that the composite is simply a blend of the different components without the formation of any other intermediate phase.…”

Section: Resultsmentioning

confidence: 99%

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

et al. 2021

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Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.

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“…The ulcerative colitis group (UC group) included ten rats that underwent induction of UC via intrarectal injection of 2 ml 4% AA as described above. UC+NC group included ten rats that underwent induction of UC and received daily oral gavage of 100 mg/kg nanocurcumin for 2 weeks [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Identification of the Molecular Basis of Nanocurcumin-Induced Telocyte Preservation within the Colon of Ulcerative Colitis Rat Model

Arafat

Marzouk

Mostafa

et al. 2021

Mediators of Inflammation

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Background. Telocytes (TCs) are a distinct type of interstitial cells that play a vital role in the pathogenesis of ulcerative colitis and colonic tissue hemostasis. The aim of this study was to examine the effect of nanocurcumin (NC) on the morphometric and immunohistochemical characterization of TCs in the ulcerative colitis (UC) rat model. Methods. Forty rats were randomly divided into control, NC, UC, and UC+NC groups. At the end of the experiment, the colon was dissected and prepared for histopathological and immunohistochemical assessment. Tissue homogenates were prepared for real-time PCR assessment of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-beta (TGF-β) gene expression. Our results revealed extensive mucosal damage with inflammatory cell infiltration, significant reduction of CD34, and vimentin immunostained TCs in the colon of the UC group with significant elevation of expression of IL-6, TNF-α, and TGF-β. The UC+NC-treated group revealed significant elevation of TC count compared to the UC group besides, a significant reduction of the three gene expression. Conclusion. NC successfully targeted the colonic tissue, improved the mucosal lesion, preserve TCs distribution, and count through its anti-inflammatory and fibrinolytic properties.

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Curcumin and Nanocurcumin Oral Supplementation Improve Muscle Healing in a Rat Model of Surgical Muscle Laceration

Cited by 11 publications

References 36 publications

Effect of chitosan and curcumin nanoparticles against skeletal muscle fibrosis at early regenerative stage of glycerol-injured rat muscles

Effect of chitosan and curcumin nanoparticles against skeletal muscle fibrosis at early regenerative stage of glycerol-injured rat muscles

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

Identification of the Molecular Basis of Nanocurcumin-Induced Telocyte Preservation within the Colon of Ulcerative Colitis Rat Model

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