Curcumin and Its Biological Importance: A Review

Dikkala, Praveen Kumar; Shirisha, Suddala

doi:10.20546/ijcmas.2018.702.137

Cited by 4 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It blocks the transformation of cancer cells, it prevents normal cells before they can be able to form tumors (tumor initiation), metastasis, angiogenesis, and invasion. Curcumin anticancer activity in vivo and in vitro revealed its capability to suppress carcinogenesis and also prevent the proliferation of many types of tumor cells [37]. The different mechanisms of action of curcumin and its molecular targets have been summarized in Table 1.…”

Section: Anticancer Activity Of Curcumin and Its Derivativesmentioning

confidence: 99%

“…The in vitro studies showed that WZ35 displayed greater antiproliferative effects on colon-cancer cells when compared to curcumin [86]. The in vitro assays of another curcumin derivative, bis-DeHydroxy curcumin (bDHC) ( 64 ) has been reported to induce the autophagy on colon-cancer cells [37]. Dimethoxy-curcumin (DMC) ( 66 ), a lipophilic derivative of curcumin, with methylated phenolic hydroxyl groups has greater chemical and metabolic stability when compared to curcumin [19,87].…”

Section: Three Different Types Of Cancersmentioning

confidence: 99%

See 1 more Smart Citation

Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers

2019

View full text Add to dashboard Cite

Cancer is a life-threatening disease and is the second leading cause of death around the world. The increasing threats of drug-resistant cancers indicate that there is an urgent need for the improvement or development of more effective anticancer agents. Curcumin, a phenolic compound originally derived from turmeric plant (Curcuma longa L. (Zingiberaceae family)) widely known as a spice and a coloring agent for food have been reported to possess notable anticancer activity by inhibiting the proliferation and metastasis, and enhancing cell cycle arrest or apoptosis in various cancer cells. In spite of all these benefits, the therapeutic application of curcumin in clinical medicine and its bioavailability are still limited due to its poor absorption and rapid metabolism. Structural modification of curcumin through the synthesis of curcumin-based derivatives is a potential approach to overcome the above limitations. Curcumin derivatives can overcome the disadvantages of curcumin while enhancing the overall efficacy and hindering drug resistance. This article reports a review of published curcumin derivatives and their enhanced anticancer activities.

show abstract

Section: Anticancer Activity Of Curcumin and Its Derivativesmentioning

confidence: 99%

Section: Three Different Types Of Cancersmentioning

confidence: 99%

Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers

2019

View full text Add to dashboard Cite

show abstract

“…Curcuma longa (Turmeric): Turmeric, derived from the rhizomes of Curcuma longa belonging to the family Zingiberaceae is the most promising, ancient, traditionally used medicinal herb known for centuries throughout the Asian countries with well-established biological activities including antioxidant, anti-inflammation and various other properties; 49,50 its usage is associated with a plethora of beneficial effects on human health 51 . Curcumin [1, 7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] also called diferuloylmethane 52 , is the main natural bioactive polyphenol 50 which regulates various biochemical and molecular pathways by modulating several molecular targets, including transcription factors, cytokines enzymes and genes regulating cell proliferation or apoptosis because of its antiinflammatory property 36 .…”

Section: Clinicallymentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

Osteoarthritis is accepted as the most growing, frequent, debilitating and heterogeneous condition that worsens the quality of life globally in the elderly, affecting an estimated 10% of men and 18% of women over 60 years of age with a rise in both prevalence and incidence. At present, there is no definite cure for osteoarthritis and no effective treatments which arrest or slow its progression; however multiple numbers of treatments ranging from newly approved oral medications, topical agents, intra-articular injections to surgery exist, but these treatments are sometimes disappointing and may have a detrimental effect on health. Hence, traditional plants appear to be efficacious and safe with the anti-osteoarthritic effect that aid for greater relief of symptoms and/or disability along with highlighting various phytochemical with scientifically proven, and validated. In this present review study, an effort is made to treat OA by focusing on the clinical, scientific and mechanistic rationale for targeting inflammatory signaling pathways in OA by use of traditional plants. INTRODUCTION:Osteoarthritis (OA) is a longterm, chronic, progressive, musculoskeletal, degenerative, a rheumatic disorder characterized by deterioration of articular cartilage 1 , hypertrophy of bone at the margins 2, 3 leading to Arthralgia, Edema and Ankylosis 4 . It is the most common and destined to become 3 more prominent 5 multifactorial diseases causing disability in the elderly age group all over the world. For the last decades, OA was considered as wear and tear disease 4 (sometimes the condition is called as arthrosis or osteoarthrosis) 7 accompanied by subchondral bone sclerosis; other intrinsic changes such as increased pressure or overload on weightbearing joints (hips), joint effusion, crepitus, and deformities 6 .

show abstract

“…[11] CUR in the form of (1E,6E) −1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione), also known as diferuloylmethane, is the primary polyphenol derived from turmeric through the extraction process . [12] It is the main representative of the curcuminoids found in the spice turmeric, and the other two curcuminoids are: dimethoxycurcumin and bis-dimethoxycurcumin (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Application of curcumine and its derivatives in the treatment of cardiovascular diseases: a review

Stamenkovska

Hadzi‐Petrushev

Nikodinovski

et al. 2021

International Journal of Food Properties

View full text Add to dashboard Cite

Cardiovascular diseases are the leading cause of death in the world and scientists pay a lot of attention to identify and reveal the mechanisms of their occurrence. Recently, the attention of scientists is focused increasingly on plant derivatives, such as flavonoids and polyphenols, due to their specific biological effects. One of these compounds is curcumin, which has many biological properties. Numerous studies have been performed to understand the molecular basis of the therapeutic properties of curcumin. As a result of these studies, there is considerable evidence to suggest that curcumin may affect signaling pathways associated with the cell growth, proliferation, survival, inflammation, and gene transcription. Antioxidant and antiinflammatory mechanisms are the two basic mechanisms to which many of the effects of curcumin in various conditions are attributed. Many factors influence the development of heart disease, but one of the main culprits in their occurrence is the inflammatory process. According to recent research, curcumin is an ingredient that could be used in the prevention or treatment of cardiovascular disease. Also, some studies have shown that it has beneficial effects in preventing vascular damage and ischemia. Despite its beneficial and biological properties, it has been proven that curcumin has relatively low bioavailability and low stability in the human body, which limits its therapeutic application. In this regard, several attempts have been made to synthesize curcumin derivatives with improved bioavailability. In this paper, we review the potential and possibilities of using curcumin and its derivatives in the treatment of cardiovascular disease, which would significantly reduce the mortality rate in the population. Based on all of the above, it can be concluded that further studies of animal models and humans are needed to verify current knowledge about the application of curcumin and its derivatives in the treatment of cardiovascular diseases. In this way through these studies more reliable data will be generated concerning the effects of curcumin and its analogs on cellular and subcellular/molecular levels. Prospectively, we believe that this will ground the basis for further improved synthesis of curcumin-analogs, appropriate for the treatment of cardiovascular diseases.

show abstract

Curcumin and Its Biological Importance: A Review

Cited by 4 publications

References 17 publications

Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers

Curcumin and Its Derivatives as Potential Therapeutic Agents in Prostate, Colon and Breast Cancers

Untitled

Application of curcumine and its derivatives in the treatment of cardiovascular diseases: a review

Contact Info

Product

Resources

About