Curcumin and its allied analogues: epigenetic and health perspectives - a review

Imran, Muhammad; Nadeem, Muhammad; Khan, Muhammad Asif; Ahmed, Sheraz; Imran, Ali; Amir, Rai Muhammad; Arshad, Muhammad Umair; Gilani, Syed Amir; Saeed, Farhan; Mehmood, Zaffar; Khan, Shaista; Suleria, Hafiz Ansar Rasul

doi:10.17221/584/2015-cjfs

Cited by 8 publications

(4 citation statements)

References 196 publications

(220 reference statements)

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“…At present, researchers work in the field of bio‐based polymer materials in comparison with conventional polymer‐based materials. But in general, the bio‐based polymer material itself limits its application in the field of packaging due to poor mechanical, thermal, barrier, and antimicrobial properties. To find effective application, the natural biopolymer has been blended with other synthetic polymers or nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

TiO₂ nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

Venkatesan

Rajeswari

2017

Polymers for Advanced Techs

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In this present study, biodegradable PBAT nanocomposites containing different weight percentages (1, 3, 5, 7, and 10% w/w) of TiO2 nanoparticles were prepared by using solvent casting technique, chloroform as a solvent. The microstructure and morphology of the as‐synthesized poly(butylene adipate‐co‐terephthalate) (PBAT)/TiO2 nanocomposite films were characterized by Fourier‐transform infrared, X‐ray diffraction, scanning electron microscopy, and transmission electron microscope. The thermal degradation of PBAT composites was studied by using thermogravimetric analysis. The mechanical strength of the films was improved by increasing TiO2 concentration. Tensile strength increased from 32.60 to 63.26 MPa, respectively. Barrier properties of the PBAT/TiO2 nanocomposites were investigated by using an oxygen permeability tester. The oxygen permeability (oxygen transmission rate) decreased with increasing the TiO2 nanoparticle concentrations. The PBAT/TiO2 nanocomposite films showed profound antimicrobial activity against both Gram‐positive and Gram‐negative foodborne pathogenic bacteria, namely, Escherichia coli and Staphylococcus aureus, to understand to the zone of inhibition. These results indicated that filler–polymer interaction is important and the role of the TiO2 as a reinforcement in the nanocomposites was evident. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

TiO₂ nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

Venkatesan

Rajeswari

2017

Polymers for Advanced Techs

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“…Curcumin (CUR) and its metabolites are well-researched natural compounds with numerous beneficial biological activities. Curcumin is produced by the plant Curcuma longa, and tetrahydrocurcumin (THC), as one of its primary in vivo metabolites, possesses several CUR-like pharmacological effects [1]. Multiple studies have investigated the protective effects of CUR and its metabolites/analogs on cardiovascular diseases (CVDs).…”

Section: Introductionmentioning

confidence: 99%

Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models

Zhang

Wang

et al. 2022

Molecules

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Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive role of THC on vascular dysfunction and the development of hypertension by exploring the effects of THC on hemodynamic status, aortic elasticity, and oxidative stress in vasculature in different animal models. We review the protective effects of THC against hypertension induced by heavy metals (cadmium and iron), as well as its impact on arterial stiffness and vascular remodeling. The effects of THC on angiogenesis in CaSki xenografted mice and the expression of vascular endothelial growth factor (VEGF) are well documented. On the other hand, as an anti-inflammatory and antioxidant compound, THC is involved in enhancing homocysteine-induced mitochondrial remodeling in brain endothelial cells. The experimental evidence regarding the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion injury and the therapeutic potential of THC to alleviate mitochondrial cerebral dysmorphic dysfunction patterns is also scrutinized and explored. Overall, the studies on different animal models of disease suggest that THC can be used as a dietary supplement to protect against cardiovascular changes caused by various factors (such as heavy metal overload, oxidative stress, and carcinogenesis). Additionally, the reviewed literature data seem to confirm THC’s potential to improve mitochondrial dysfunction in cerebral vasculature during ischemic stroke through epigenetic mechanisms. We suggest that further preclinical studies should be implemented to demonstrate THC’s vascular-protective, antiangiogenic, and anti-tumorigenic effects in humans. Applying the methods used in the presently reviewed studies would be useful and will help define the doses and methods of THC administration in various disease settings.

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“…One of the directions of their modification is the oxyfunctionalization of cycles А, C, and E, leading to new bioactive compounds [3][4][5][6][7][8][9][10][11][12][13][14].…”

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confidence: 99%

“…13β,28-lactones and 12-oxo-13β,28-lactones [14]. The oxidative lactonization of ursolic acid was effected with H 2 O 2 with the generation of 12β-hydroxy-13β,28-lactone [32].…”

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Oxidative lactonization of oleanane and ursane acids by treating with ozone

et al. 2015

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Features of process of oxidative lactonization of 3-oxooleanolic and 3-oxoursolic acids under treatment with ozone were established. The similarity of the processes consists in generation of 3-oxooleanolic or 3-oxoursolic 13β,28-lactones with 12-oxo or 12-hydroxy group. In the case of ursane derivative the generation exclusively of compounds with β-oriented 12-hydroxy group was observed, in the case of oleanane lactones prevailingly compounds with α-oriented 12-hydroxy group were obtained. The processes differ by the generation of the product of allylic oxidation, 3,11-dioxoursolic acid, or the isolation of the product of the lactone cycle opening with participation of the solvent, 3,12-dioxoolean-28-olic acid.Oleanolic and ursolic acids, belonging to triterpenoids of the series of β-and α-amirine, are widely spread in plants and exhibit various pharmacological properties [1, 2]. One of the directions of their modification is the oxyfunctionalization of cycles А, C, and E, leading to new bioactive compounds [3][4][5][6][7][8][9][10][11][12][13][14].One of the successful examples of oxidative functionalization of oleanolic acid that should be mentioned is the synthesis of 2-cyano-3,12-dioxo-olean-1 (2),9(11)-dien-28-olic acid (CDDO), possessing antiphlogistic, antitumor, antidiabetic, and antiangiogenic activity [15][16][17][18][19]. Methyl ester CDDO (methyl bardoxolone) passed the first phase of clinical trials as a drug for cancer treatment and second phase as a drug for treatment of chronical kidney diseases for patients suffering from sugar diabetes of the second type [5]. 12-Hydroxy-11-oxoolean-12-enes[3] exhibited a high cytotoxicity. 3β,12α-Dihydrooxyoleanolic 13β,28-olide is the key intermediate in the synthesis of endoteline of A receptors and a promising antidiabetic agent [8]. 2-Cyano-3-oxo-12α-fluorours-1-ene-13β,28-olide is effective against the cancer cells of pancreatic gland [20]. One of the products of oxidative transformation of ursolic acid in the presence of ruthenium porphyrins, 12β-hydroxyurs-11-ene-13β,28-olide, proved to be active against the cancer cells of human skin А431 [9, 10].Despite the fact that triterpenoids of the series of α-and β-amirine have very close structure and differ only by the position of a single methyl group in the E cycle, there is a significant difference in their oxidation processes. For example, the oxidation of methyl ursolate with ozone proceeds with generation of 12-oxo-11S,13R-oxetane fragment in the cycle С [21], whereas the oxidation of methyl oleanate leads to methyl 12-oxooleane [22]. Different courses of oxidation processes of triterpenoids belonging to the α-and β-amirine series with reagents like m-chloroperoxybenzoic acid and HCOOH-H 2 O 2 underlie their separation in the form of oxyderivatives, because in plants these metabolites often accompany each other [3,23,24].In continuation of our research on the oxidative transformations of vegetable terpenoids [25][26][27][28][29][30][31] we investigated in the present study the oxidation of С 12 =С 13 bond...

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Curcumin and its allied analogues: epigenetic and health perspectives - a review

Cited by 8 publications

References 196 publications

TiO₂ nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

TiO₂ nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models

Oxidative lactonization of oleanane and ursane acids by treating with ozone

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Curcumin and its allied analogues: epigenetic and health perspectives - a review

Cited by 8 publications

References 196 publications

TiO2 nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

TiO2 nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models

Oxidative lactonization of oleanane and ursane acids by treating with ozone

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TiO₂ nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications

TiO₂ nanoparticles/poly(butylene adipate‐co‐terephthalate) bionanocomposite films for packaging applications