Curcumin and Health

Pulido-Morán, Mario; Moreno‐Fernández, Jorge; Ramírez-Tortosa, César L.; Ramírez-Tortosa, M. C.

doi:10.3390/molecules21030264

Cited by 434 publications

(293 citation statements)

References 200 publications

(221 reference statements)

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“…Nonetheless, although inexpensive, apparently well tolerated, and potentially active, curcumin has yet not been approved for treatment of any human disease/ailment [20]. Despite thousands of research papers, wide range of pharmacological activities of curcumin reported in the past decades, more than 120 reported clinical trials, still a paradox and uncertainty remains regarding the pharmacology of curcumin owing to its physicochemical properties leading to the poor systemic bioavailability [23,24].…”

Section: Curcumin Research: What Is the Current Scenario?mentioning

confidence: 99%

“…Just like another well studied biomolecule, quercetin [5][6][7]13,14], curcumin has also received considerable attention over the past decades, which is mainly due to its diverse biological activities, including but not limited to antioxidant, anti-inflammatory, anti-arthritic, anti-ulcer, anti-diabetic, anti-bacterial activities and its potential therapeutic applications in a large number of diseases including but not limited to cancer and neurodegenerative diseases (Figure 1) [4,11,12,[15][16][17][18][19]. Hence, curcumin is used as a supplement/neutraceutical in several countries, including but not limited to India, Japan, America, Thailand, China, Korea, Turkey, South Africa, Nepal, Bangladesh, Sri Lanka and Pakistan owing to its perceived potential health benefits [20].…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical Developability of Clinically Relevant Flavonoids like Curcumin: Why are We Failing?

D¹,

Jayanthi²,

Joshi³

2017

Med Clin Rev

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Flavonoids are promising therapeutic class of polyphenolic biomolecules with the potential to alleviate many severe disease states with multi-factorial pathogenesis because of their inherent ability to regulate key biological cascades at the molecular, cellular and organism levels. However, these important polyphenolic compounds frequently pose drug delivery challenges to scientists and produce inefficient pharmacokineticpharmacodynamic activities. Importantly, despite their therapeutic potential and the focus of the scientists being on the formulation development front in the recent years, developing an ideal drug delivery system for some of the most important polyphenolic biomolecules such as curcumin is still a challenge. Hence, the basic intent of writing this article is to bring back the focus of the formulation scientists on one of the key physicochemical properties of these important biomolecules i.e., the importance of pH-stability profile of flavonoids, which could play vital role in the formulation developability aspects of important biomolecules such as curcumin by the selection of an ideal dosage form.

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Section: Curcumin Research: What Is the Current Scenario?mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Developability of Clinically Relevant Flavonoids like Curcumin: Why are We Failing?

D¹,

Jayanthi²,

Joshi³

2017

Med Clin Rev

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“…Curcumin is the compound responsible for the chemical and biological properties of this spice, as well as its color and taste. Numerous studies have shown that curcumin is associated with antioxidant, anti-inflammatory, antimutagenic, antimicrobial, and anticancer effects, mitigating chronic diseases and increasing longevity [37,38]. HSPs, HSF1, and histone deacetylase (HDAC) 6 are upregulated in cancer.…”

Section: Curcuminmentioning

confidence: 99%

Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity

Gezer¹

2018

Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics

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The stress responses observed in mammalian cells can be classified as heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid damage response, antioxidant response, and sirtuin response at the intracellular and molecular levels. Factors that strengthen the hemodynamic structure causing low-level molecular damage and activating one or several stress response pathways are called hormetins. Hormetins can be categorized as physical, physiological, biological, and nutritional hormetins. Nutritional hormetins provide an interesting, comprehensive research topic because of their effects on health and lifespan. Dietary phytochemicals, with their low-level stress-inducing effects, are potential nutritional hormetins. Resveratrol, curcumin, epicatechin, isothiocyanates, ferulic acid, and certain vitamin-minerals can induce a heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid damage response, antioxidant response, and sirtuin response causing the stimulation of kinases and transcription factors. Studies have shown that these phytochemicals are related to nuclear factor-erythroid 2, sirtuins, nuclear factor-kappa B, and heat shock response pathways. In this chapter, the stress response of dietary phytochemicals will be systematically examined in a hormetic manner for delay of age-related diseases, healthy aging, and longevity based on current data.

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“…What is more, extensive research over the last half century has revealed several important functions of curcumin. Such effects include antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, anticarcinogenic, thrombosuppressive and cardiovascular [2].…”

Section: Mini Reviewmentioning

confidence: 99%