Curcumin and Dimethoxycurcumin Induced Epigenetic Changes in Leukemia Cells

Hassan, Hazem E.; Carlson, Samuel; Abdallah, Inas A.; Buttolph, Thomm; Glass, Karen C.; Fandy, Tamer E.

doi:10.1007/s11095-014-1502-4

Cited by 42 publications

(43 citation statements)

References 41 publications

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“…In this present work, we use curcumin as a model drug and aim to provide a novel approach for enhancing the chemical stability of drug molecules loaded in liposome. It is well known that curcumin is a lipophilic molecule and has been extensively used in food, medicines, and cosmetics due to its various bioactivities [17][18][19][20][21]. However, its delivery is highly limited by its insolubility and instability in biological fluids [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug

et al. 2017

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Liposome is a promising carrier system for delivering bioactive molecules. However, the successful delivery of pH-sensitive molecules is still limited by the intrinsic instability of payloads in physiological environment. Herein, we developed a special liposome system that possesses an acidic micro-environment in the internal aqueous chamber to improve the chemical stability of pH-sensitive payloads. Curcumin-loaded liposomes (Cur-LPs) with varied internal pH values (pH 2.5, 5.0, or 7.4) were prepared. These Cur-LPs have similar particle size of 300 nm, comparable physical stabilities and analogous in vitro release profiles. Interestingly, the chemical stability of liposomal curcumin in 50% fetal bovine serum and its anticancer efficacy in vitro are both micro-environmental pH-dependent (Cur-LP-2.5 > Cur-LP-5.0 > Cur-LP-7.4). This serum stability still has space to be further enhanced to improve the applicability of Cur-LP. In conclusion, creating an acidic micro-environment in the internal chamber of liposome is feasible and efficient to improve the chemical stability of pH-sensitive payloads.

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Section: Introductionmentioning

confidence: 99%

Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug

et al. 2017

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“…In addition, curcumin reduced the expression of the positive regulators of DNMT1, p65 and Sp1, which correlates with reductions in the binding of these transcription factors to the DNMT1 promoter in AML cell lines, demonstrating the promise of curcumin as a potential treatment for AML [29]. More recently, dimethoxycurcumin, a synthetic structural analog of curcumin, along with other epigenetic modifiers [e.g., 5-azacytidine (5AZA) and decitabine], was shown to augment the effect of DNMT inhibitors on DNA methylation to reactivate the silenced genes in leukemia cells [30]. In addition to its regulatory role in blood cancers, curcumin is a potent epigenetic regulatory agent in many solid tumors.…”

Section: Introductionmentioning

confidence: 99%

“Curcumin, the King of Spices”: Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases

2015

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Curcumin (diferuloylmethane), a polyphenolic compound, is a component of Curcuma longa, commonly known as turmeric. It is a well-known anti-inflammatory, anti-oxidative, and anti-lipidemic agent and has recently been shown to modulate several diseases via epigenetic regulation. Many recent studies have demonstrated the role of epigenetic inactivation of pivotal genes that regulate human pathologies, such as neurocognitive disorders, inflammation, obesity, and cancers. Epigenetic changes involve changes in DNA methylation, histone modifications, or altered microRNA expression patterns which are known to be interconnected and play a key role in tumor progression and failure of conventional chemotherapy. The majority of epigenetic changes are influenced by lifestyle and diets. In this regard, dietary phytochemicals as dietary supplements have emerged as a promising source that are able to reverse these epigenetic alterations, to actively regulate gene expression and molecular targets that are known to promote tumorigenesis, and also to prevent age-related diseases through epigenetic modifications. There have been several studies which reported the role of curcumin as an epigenetic regulator in neurological disorders, inflammation, and in diabetes apart from cancers. The epigenetic regulatory roles of curcumin include (1) inhibition of DNA methyltransferases (DNMTs), which has been well defined from the recent studies on its function as a DNA hypomethylating agent; (2) regulation of histone modifications via regulation of histone acetyltransferases (HATs) and histone deacetylases (HDACs); and (3) regulation of micro RNAs (miRNA). This review summarizes the current knowledge on the effect of curcumin in the treatment and/or prevention of inflammation, neurodegenerative diseases, and cancers by regulating histone deacetylases, histone acetyltransferases, and DNA methyltransferases.

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“…Moreover, recent studies has shown utilization of curcumin in nano formulation and microemulsified forms to increase its bioavailability and site specific action in particular to cancer cells[32, 79,80].Curcumin and its related analogues has also been witnessed to induce epigenetic changes in tumour cells including PC with ability to modulate of histone acetylation by inhibiting histone acetylase [81,82], inducing apoptosis [83], Downregulation of AR and its binding ability [82], regulation of epidermal growth factor receptor(EGFR) tyrosine kinase activity [84,85],inhibition of angiogenesis/vascular endothelial growth factor(VEGF) [86,87], inhibition of cell proliferation in androgen independent and dependent PC cell lines via modulation of Wnt transcriptional activity medicated by low expression of protein in Wnt transcriptional complex [77,[88][89][90][91][92][93].…”

Section: Curcumin (Diferuloylmethane)mentioning

confidence: 99%

Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to Prostate cancer

Bais

Kumari

Prashar

2017

JAD

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Curcumin and Dimethoxycurcumin Induced Epigenetic Changes in Leukemia Cells

Cited by 42 publications

References 41 publications

Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug

Effects of Micro-environmental pH of Liposome on Chemical Stability of Loaded Drug

“Curcumin, the King of Spices”: Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases

Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to Prostate cancer

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