Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat

Barthelemy, Sophie; Vergnes, Laurent; Moynier, Marinette; Guyot, Deborah J.; Labidalle, Serge; Bahraoui, Elmostafa

doi:10.1016/s0923-2516(97)86899-9

Cited by 109 publications

(66 citation statements)

References 33 publications

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“…It is a polyphenolic ingredient which is considered as major antioxidant, coloring and flavoring agent in the balanced diet (Yao et al 2011). Several studies have been published reporting pluripotent pharmacolological actions of Curcumin e.g., anticancer (Ketron and Osheroff 2014), antiretroviral (Barthelemy et al 1998), antiinflammatory (Kant et al 2014), antidiabetic (Zhang et al 2013), antidepressant (Pathak et al 2013), anti-alzheimer (Lazar et al 2013), antioxidant (Khalil and Ali 2011), antibacterial (Gunes et al 2013), antifungal (Sharma 2012) etc. These varied medicinal benefits also suggest application of this extraordinary molecule as a functional food (nutraceutical) ingredient.…”

Section: Introductionmentioning

confidence: 99%

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

2015

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The supramolecular nano-assemblies formed by electrostatic interactions of two oppositely charged lipid and polymer have been made and used as nanocarriers for curcumin to address its bioavailability and solubility issues. These curcumin encapsulated nano-supramolecular assemblies were characterized with respect to their size (dynamic light scattering), morphology (TEM, SEM), zeta potential (Laser Doppler Velocimetry), encapsulation efficiency (EE), curcumin loading (CL) etc. Stability of the nano-assemblies was assessed at different storage times as a function of varying pH and temperature. The physicochemical characterization of nano-assemblies was performed using Fourier Transform Infra Red Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC). The in-vitro antioxidant lipid peroxidation (TBARS), radical scavenging (DPPH, NO, H 2 O 2 , reducing power) activity assays of powdered curcumin and nanoencapsulated curcumin were performed. It was found that nano-encapsulated curcumin were roughly spherical in shape, presented high positive zeta potential (>30 mV), monodisperse (polydispersity index <0.3), amorphous in nature, stable in the pH range of 2-6 and have enhanced antioxidant potency in comparison to crystalline curcumin in aqueous media. In conclusion, the curcumin encapsulated nanocarriers system has great potential as functional food ingredient of natural origin.

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Section: Introductionmentioning

confidence: 99%

Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications

2015

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“…[138] It was also found that curcumin and its derivatives, specifically, reduced curcumin, allyl-curcumin, and tocopheryl-curcumin, discovered 70-85% inhibition in Tat protein transactivation of HIV-1 LTR measured by β-galactosidase activities of HeLa cells which in HIV-1 LTR was fused to the indictor of lac Z gene. [139] Furthermore, curcumin reserved the acetylation of Tat protein of HIV significantly by p300 related with invasion of HIV-1 multiplication. Curcumin by targeting the acetyltransferase proteins of p300/CREB binding protein can be a potent compound for combinatorial HIV therapeutics.…”

Section: Antiviral Effectmentioning

confidence: 99%

Untitled

Ashraf¹

2017

IJGP

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Curcuma longa Linn. is well-known and valued medicinal plant. It has a long history of traditional uses ranging from folk medicine to several culinary preparations. The phytochemical, pharmacological, and molecular studies of C. longa are reviewed. The rhizome is rich in essential oils, and various numbers of chemical constituents with biomedical significance have been isolated from it. The management of indigenous knowledge by appropriate documentation is recommended. This review was compiled to provide recent consolidated information covering different aspects of the plant, phytochemical, pharmacological, and molecular study to provide a basis on which to plan future studies and to promote sustainable use of C. longa.

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“…Curcumin and its dedvative containing boron inhibited the HIV 1 protease (45). Curcumin used at the concentration of 10 to 100 nmol inhibited Tat transcription of HIV I-Itr Lac Z by 70-80% in HeLa cell models (46). Curcumin is also known to inhibit DNA polyrnerase, HIV and avian myeloblastosis virus reverse transoriptase (1).…”

Section: Anttviral Activitymentioning

confidence: 99%