Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases

Abstract

Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.

Curcumin as a Potential Therapeutic Agent for Mitigating Carbon Monoxide Poisoning: Evidence from an Experimental Rat Study

“…Curcumin has been reported to have preventive properties in many diseases, especially acute or chronic neurological diseases, due to its antioxidant and anti-inflammatory properties [17,18]. While the precise mechanism of action of curcumin remains incompletely understood, these beneficial effects of curcumin were found to be mainly associated with its ability in ROS scavenging [19]. The main proposed mechanisms of curcumin include hydrogen peroxide scavenging activity, which is attributed to the abstraction of hydrogen atoms from free hydroxyl groups, similar to a-tocopherol and vitamin C [20].…”

Expression and prognosis of ADAMTS18 in different tumors

“…Curcumin, as a medicinal plant, has become a hotspot of tumor research in recent years due to its excellent anti-inflammatory and antioxidant effects ( 111 , 112 ). ADAMTS18 can assist curcumin in inhibiting the occurrence and development of ccRCC.…”

Host-directed therapy against mycobacterium tuberculosis infections with diabetes mellitus

“…Curcumin, a component of traditional medicine derived from turmeric, is a lipophilic polyphenol. Curcumin has demonstrated impressive therapeutic efficacy in inflammatory, tumor, and infectious diseases, accompanied by low cost and excellent tolerability ( 118 ). Curcumin treatment induced autophagy and apoptosis in infected/uninfected MTB macrophages, with the conversion of LC3-I to LC3-II, the degradation of p62, and upregulation of the pro-apoptotic proteins Bax, Casp3, and PARP, as well as the reduced expression of the anti-apoptotic protein Bcl ( 119 ).…”