Curcumin: Analysis and Stability

Zaghary, Wafaa A.; Hanna, Emily T; Zanoun, Marwa; Abdallah, Nermeen; Sakr, Tamer M.

doi:10.21608/aprh.2019.6191.1069

Cited by 4 publications

(2 citation statements)

References 97 publications

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“…The detection and characterization of curcuminoids in different matrices are of great importance. The choice of the analytical method for curcuminoid analysis depends on the sample type, the purpose of the analysis, and the detection and quantification limits [ 67 , 68 ]. The techniques based on chromatography and electrophoresis are among the selected methods for determining curcuminoids.…”

Section: Characterization Of Curcuminmentioning

confidence: 99%

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Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.

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Section: Characterization Of Curcuminmentioning

confidence: 99%

“…Liquid chromatography–mass spectrometry (LC/MS) [ 67 ] is used to identify and quantify traces of curcumin in biological fluids, food, or other complex matrices. Various LC/MS methods have been developed to detect and quantify curcumin in different matrices [ 77 , 78 , 79 ].…”

Section: Characterization Of Curcuminmentioning

confidence: 99%

Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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Preparation and characterization of nanoemulsion herbal drinks using natural deep eutectic solvent and virgin coconut oil

Krisanti,

Tobing,

Mulia

2024

The 17th International Conference on Quality in Research (Qir) 2021 in Conjunction With the 6th Itrec 2021 and the 2nd Caic-Siu

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Quality by Design-based RP-HPLC Method for Estimation of Curcumin in Rat Plasma and Fecal Microbiota Extract-based Solid Self-nano Emulsifying Drug Delivery System

Singh

Corrie

Gulati

et al. 2023

CDRR

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Background: Curcumin (CRM) is known to possess various therapeutic properties, such as anti-inflammatory and antidiabetic properties, and is, therefore, considered to be an effective therapeutic. Objective: A sensitive method for the estimation of CRM in plasma, as well as fecal matter-based solid self-nano emulsifying drug delivery system (S-SNEDDS), has been reported for the first time. Methods: A bioanalytical method was optimized using Box-Behnken Design having 13 runs and 3 responses. The optimized method was developed using methanol and water (70:30 v/v) with a flow rate of 1 mL/min. Quercetin was used as an internal standard. A specificity test was also performed for the developed CRM solid self-nano emulsifying drug delivery system. Results: The retention time of CRM was found to be 14.18 minutes. The developed method was validated and found to be linear in the range of 50-250 ng/mL with an R2 of 0.999. Accuracy studies indicated that CRM had a percentage recovery of less than 105% and more than 95%, respectively. Precision studies were carried out for inter, intraday, and inter-analyst precision, and the %RSD was found to be less than 2%. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 3.37 ng/mL and 10.23 ng/mL, respectively. Stability studies for short-term, long term and freeze-thaw cycles showed a %RSD of less than 2%, indicating the stability of CRM in the plasma matrix. Moreover, the blank fecal microbiota extract slurry did not show any peak at the retention time of CRM in a CRM-loaded solid nanoemulsifying drug delivery system containing fecal microbiota extract indicating its specificity. Conclusion: Hence, the developed method can have clinical implications as it helps estimate CRM in blood samples and also provides a simple and sensitive method for the estimation of plant-based flavonoids along with fecal microbiota extract formulations.

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Curcumin: Analysis and Stability

Cited by 4 publications

References 97 publications

Curcumin: Biological Activities and Modern Pharmaceutical Forms

Curcumin: Biological Activities and Modern Pharmaceutical Forms

Preparation and characterization of nanoemulsion herbal drinks using natural deep eutectic solvent and virgin coconut oil

Quality by Design-based RP-HPLC Method for Estimation of Curcumin in Rat Plasma and Fecal Microbiota Extract-based Solid Self-nano Emulsifying Drug Delivery System

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