Curcumin, an Anti-tumor Promoter and Anti-inflammatory Agent, Inhibits Induction of Nitric Oxide Synthase in Activated Macrophages

Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions

“…[15,33] and possible suppression of BACE1 induction, it is likely that no one mechanism is involved. Curcumin also inhibits known amyloid response pathways including JNK kinase and iNOS expression in vitro [5,12,23] and in vivo [10,13] and in CNS (our data). Thus, curcumin should be able to suppress not only A␤ but key aspects of the response to A␤ that are JNK-and iNOS-dependent including LTP inhibition [30], reported to depend on JNK, iNOS, and microglial radicals [31].…”

Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor

“…PPAR-␥ agonists are presumed to exist in the media with 10% FBS (29,36,56). Activation of PPAR-␥ is required for curcumin to inhibit HSC activation, including reduced cell growth and suppressed ECM gene expression (8,9). In the present report, we observed that blockade of PPAR-␥ activation by its antagonist abrogated the inhibitory effect of curcumin on CTGF gene expression (Fig.…”

“…Curcumin inhibits lipid peroxidation (45,49), nitric oxide synthase activity (9), and production of ROS (31). These unique features might allow curcumin to succeed where other regular antioxidants have failed in the inhibition of hepatic fibrogenesis.…”

Curcumin as “Curecumin”: From kitchen to clinic

“…Throughout the Orient, it has traditionally been used to good therapeutic effect, particularly as an anti-inflammatory [12], and many of its therapeutic effects have been confirmed by modern scientific research. Such effects include antioxidant [27], anti-inflammatory [24,28,29], anticarcinogenic and antimicrobial [30][31][32], hepatoprotective [32], thrombosuppressive [33], cardiovascular (i.e., as protection against myocardial infarction) [29,34,35], hypoglycemic [36][37][38], and antiarthritic (i.e., as protection against rheumatoid arthritis) [39], The most compelling and key rationale for the continuing traditional therapeutic use of curcumin is its extremely good safety profile. To date, no studies in either animals [40,41] or humans [42] have discovered any toxicity associated with the use of curcumin, and it is clear that curcumin is not toxic even at very high doses.…”