Curcumin: an adjuvant therapeutic remedy for liver cancer

Sharma, Shilpa; Tanwar, Anshul; Gupta, Devendra K.

doi:10.20517/2394-5079.2015.59

Cited by 7 publications

(4 citation statements)

References 75 publications

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“…C60 has been studied, along with other antioxidants in the prevention and treatment of cancers of various types [33,34]. Dr. Shilpa Sharma at the All-India Institute of Medical Sciences has studied the impact of antioxidants on hepatocellular cancers [35,36].…”

Section: Prevention and Treatment Of Cancermentioning

confidence: 99%

Carbon 60: Vision for the Future

W Heflich

2023

Act Scie Nutr

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Carbon 60, or C60 is one of the most interesting and potentially useful molecules discovered in recent decades. It has the potential to enhance the health of people and animals, extending longevity, while reducing the impact of pain and disease. We have not yet begun to realize the many opportunities to apply C60 to treat and prevent disease conditions in humans and animals. What is carbon 60?Carbon 60, also known as C60, C 60 , fullerene, buckminsterfullerene, and buckyballs, is composed entirely of carbon; 60 carbon atoms, bonded in the shape of a soccer ball. It was named in honor of Buckminster Fuller, the inventor of the geodesic dome, because it has a geodesic structure. This shape gives it many unique and potentially useful properties. The 60 carbon atoms are bonded with alternating double and single bonds: 30 double bonds and 20 single bonds in all. The structure created is made up of hexagons and pentagons, making it resilient and extremely strong. Unique properties of C60C60 has several unique properties that make it a powerful antioxidant, capable of neutralizing highly reactive free radical molecules. No other antioxidant molecule has these properties or can neutralize as many free radical molecules. •Small size (0.72 nm diameter)• Hydrophobicity (solubility in water 1.0 X 10 -11 gm/ml) • Ability to donate 24 electrons to neutralize unstable free radical molecules • Ability to absorb 6 protons to irreversibly neutralize unstable free radical molecules • No exhibited toxicity at any level tested -composed only of carbon C60-Macromolecule not nanomaterial C60 has been called a nanoparticle but it is actually a macromolecule. At 0.72 nanometers in diameter, it is below the defined size of a nanoparticle of 1 nanometer. That may be a matter of definition, however, it is meaningful that a free C60 molecule is not a finely divided solid particle, as is true of nanoparticles. The chem-Free radical molecules Free radical molecules are molecules that have an unpaired electron or proton (hydrogen atom) [1]. Stable molecules have electrons in pairs with opposite spin. A molecule with an unpaired electron is highly reactive and will react quickly with a neighboring

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Section: Prevention and Treatment Of Cancermentioning

confidence: 99%

Carbon 60: Vision for the Future

W Heflich

2023

Act Scie Nutr

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“…In many of these studies, activation of epithelial-mesenchymal transition [EMT] program has been suggested as the mechanism linked to acquisition of invasive phenotype and the subsequent systemic dissemination of the epithelial cancer cells [13]. Due to the high recurrence rates and development of adverse effects after therapy, as well as the fact that liver cancer is typically discovered at an advanced stage since the lack of symptoms during early stages of the disease, the current management of HCC is not satisfactory [14,15]. Recently, a considerable attention has been paid to the use of natural polyphenols as a prophylactic and therapeutic remedy for liver cancer.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma

Bayoumi,

Khalifa,

Sayed-Ahmed

et al. 2023

Journal of advanced Biomedical and Pharmaceutical Sciences

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Hepatocellular carcinoma [HCC] is a brutally aggressive cancer that puts a tremendous amount of strain on both the medical systems and the drug regulatory organizations as well. It is believed that a crucial stage in the development of HCC is the epithelial-mesenchymal transition [EMT], which increases hepatocyte malignancy and is linked to invasion and metastasis. Resveratrol [RES] has been shown to reverse EMT in a number of cancer types. In order to further understand how RES influences EMT in HCC, we have chosen to concentrate on studying and summarizing the serine/threonine kinase [Akt]/glycogen synthesis kinase 3-beta [GSK3β]/Snail signaling pathway as one of the central pathways involved in activating EMT and tumorigenesis in this review.

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“…Recent studies have shown that Cur can inhibit the proliferation, invasion, and metastasis of liver cancer cells[ 6 ]. Cur has been demonstrated to inhibit the proliferation of hepatoma cell line (HepG2 cells) in a dose- and time-dependent manner[ 7 ]. The current preclinical model studies in vivo and in vitro have shown that Cur, along with other curcuminoids, has immense potential as a curative agent for liver cancer, based on its potent antioxidant and anti-inflammatory properties and its ability to regulate a variety of signaling mechanisms[ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic anti-liver cancer effects of curcumin and total ginsenosides

Deng

Yunita

et al. 2020

WJGO

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BACKGROUND Liver cancer is the sixth most frequently occurring cancer in the world and the fourth most common cause of cancer mortality. The pathogenesis of liver cancer is closely associated with inflammation and immune response in the tumor microenvironment. New therapeutic agents for liver cancer, which can control inflammation and restore cellular immunity, are required. Curcumin (Cur) is a natural anti-inflammatory drug, and total ginsenosides (TG) are a commonly used immunoregulatory drug. Of note, both Cur and TG have been shown to exert anti-liver cancer effects. AIM To determine the synergistic immunomodulatory and anti-inflammatory effects of Cur combined with TG in a mouse model of subcutaneous liver cancer. METHODS A subcutaneous liver cancer model was established in BALB/c mice by a subcutaneous injection of hepatoma cell line. Animals were treated with Cur (200 mg/kg per day), TG (104 mg/kg per day or 520 mg/kg per day), the combination of Cur (200 mg/kg per day) and TG (104 mg/kg per day or 520 mg/kg per day), or 5-fluorouracil combined with cisplatin as a positive control for 21 d. Tumor volume was measured and the protein expression of programmed cell death 1 and programmed cell death 1 ligand 1 (PD-L1), inflammatory indicators Toll like receptor 4 (TLR4) and nuclear factor-κB (NF-κB), and vascular growth-related factors nitric oxide synthases (iNOS) and matrix metalloproteinase 9 were analyzed by Western blot analysis. CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) were counted by flow cytometry. RESULTS The combination therapy of Cur and TG significantly inhibited the growth of liver cancer, as compared to vehicle-treated animals, and TG showed dose dependence. Cur combined with TG-520 markedly decreased the protein expression of PD-L1 ( P < 0.0001), while CD4 + CD25 + Foxp3 + Tregs regulated by the PD-L1 signaling pathway exhibited a positive correlation with PD-L1. Cur combined with TG-520 also inhibited the cascade action mediated by NF-κB ( P < 0.0001), thus inhibiting the TLR4/NF-κB signalling pathway ( P = 0.0088, P < 0.0001), which is associated with inflammation and acts on PD-L1. It also inhibited the NF-κB-MMP9 signalling pathway ( P < 0.0001), which is associated with tumor angiogenesis. CONCLUSION Cur combined with TG regulates immune escape through the PD-L1 pathway and inhibits liver cancer growth through NF-κB-mediated inflammation and angiogenesis.

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Curcumin: an adjuvant therapeutic remedy for liver cancer

Cited by 7 publications

References 75 publications

Carbon 60: Vision for the Future

Carbon 60: Vision for the Future

Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma

Synergistic anti-liver cancer effects of curcumin and total ginsenosides

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