Curcumin ameliorates glyoxylate-induced calcium oxalate deposition and renal injuries in mice

Li, Yinhui; Zhang, Jie; Liu, Haiyun; Yuan, Ji‐hang; Yin, Yupeng; Wang, Tiantian; Cheng, Bingfeng; Sun, Shuhan; Guo, Zhiyong

doi:10.1016/j.phymed.2019.152861

Cited by 52 publications

(36 citation statements)

References 39 publications

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“…Excessive ROS can quickly react with intracellular macromolecules, causing damage to normal cell function and eventually cell death. This oxidative cell damage can promote the deposition of CaOx crystals in the kidney [44]. Figure 11 shows the effect of nano-COM crystals on the ROS levels of HK-2 cells before and after CSPi treatment.…”

Section: Cspi Protection Reduces Reactive Oxygen Species Levelsmentioning

confidence: 99%

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Chen

Sun

Ouyang

2020

Oxidative Medicine and Cellular Longevity

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Corn silk polysaccharide (CSP0; molecular weight=124 kDa) was degraded by ultrasonication to obtain five degraded polysaccharides, namely, CSP1, CSP2, CSP3, CSP4, and CSP5, with molecular weights of 26.1, 12.2, 6.0, 3.5, and 2.0 kDa, respectively. The structures of these polysaccharides were characterized by FT-IR, 1H NMR, and 13C NMR analyses. The antioxidant activities, including scavenging ability for hydroxyl radicals and DPPH free radicals, chelation ability for Fe2+ ions, and reducing ability of CSP increased with decreased molecular weight of CSPs within 6.0 to 124 kDa. However, antioxidant activity weakened when the molecular weight of CSPs reached 3.5 and 2 kDa. CSP3 with a molecular weight of 6.0 kDa exhibited the strongest antioxidant activity. After protection with 60 μg/mL CSPs, the viability of human renal proximal tubular epithelial cells (HK-2) damaged by nano-COM crystals increased, the level of reactive oxygen species decreased, and the amount of COM crystal adhered onto the cell surface decreased. The ability of CSPs to protect cells from CaOx crystal damage was consistent with their antioxidant activity. CSPs can specifically combine with CaOx crystal to inhibit the conversion of calcium oxalate dihydrate crystal to calcium oxalate monohydrate crystal. All these results showed that the activity of CSPs was closely correlated with molecular weight. A very high or low molecular weight of CSPs was not conducive to their activity. CSPs, especially CSP3 with a molecular weight of 6.0 kDa, can be used as a potential antistone drug.

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Section: Cspi Protection Reduces Reactive Oxygen Species Levelsmentioning

confidence: 99%

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Chen

Sun

Ouyang

2020

Oxidative Medicine and Cellular Longevity

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“…Urolithiasis is a common urologic condition with an increasing incidence [1][2][3]. In Asia, about 1-19.1% of the population suffers from urolithiasis [4].…”

Section: Introductionmentioning

confidence: 99%

The Handling of Oxalate in the Body and the Origin of Oxalate in Calcium Oxalate Stones

Huang¹,

Zhang²,

Pai³

et al. 2019

Urol Int

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Urolithiasis is one of the most common urologic diseases in industrialized societies. More than 80% of renal stones are composed of calcium oxalate, and small changes in urinary oxalate concentrations affect the risk of stone formation. Elucidation of the source of oxalate and its mechanism of transport is crucial for understanding the etiology of urolithiasis. Sources of oxalate can be both endogenous and exogenous. With regard to oxalate transport, tests were carried out to prove the function of solute-linked carrier 4 (SLC4) and SLC26. The molecular mechanism of urolithiasis caused by SLC4 and SLC26 is still unclear. The growing number of studies on the molecular physiology of SLC4 and SLC26, together with knockout genetic mouse model experiments, suggest that SLC4 and SLC26 may be a contributing element to urolithiasis. This review summarizes recent research on the sources of oxalate and characterization of the oxalate transport ionic exchangers SLC4 and SLC26, with an emphasis on different physiological defects in knockout mouse models including kidney stone formation. Furthermore, SLC4 and SLC26 exchangers provide new insight into urolithiasis and may be a novel therapeutic target for modification of urinary oxalate excretion.

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“…Nephrolithiasis is one of the most prevalent urologic disorders and impose a substantial burden on human health globally [ 1 ]. The high recurrence rate of kidney stones is yet unsolved [ 2 , 3 ].Thus, there is an urgent need to target modifiable risk factors to prevent the development and recurrence of renal stones.…”

Section: Introductionmentioning

confidence: 99%

The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis

et al. 2020

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Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation. Results: Of 264 participants, 61.4% (n = 162), 72% (n = 190), 74.6% (n = 197), 68.6% (n = 181), and 80.3% (n = 212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P = ≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR = 2.80, 95%CI: 1.10-7.12, P trend = 0.04), hypercalciuria (OR = 7.44, 95%CI: 2.62-21.14, P trend ≤ 0.001), hyperuricosuria (OR = 2.22, 95%CI: 1.001-4.95, P trend = 0.05), and hypocitraturia (OR = 5.84, 95%CI: 2.14-15.91, P trend ≤ 0.001). No association was identified between DII and hyperoxaluria.

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Curcumin ameliorates glyoxylate-induced calcium oxalate deposition and renal injuries in mice

Cited by 52 publications

References 39 publications

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

Modulation of Calcium Oxalate Crystal Growth and Protection from Oxidatively Damaged Renal Epithelial Cells of Corn Silk Polysaccharides with Different Molecular Weights

The Handling of Oxalate in the Body and the Origin of Oxalate in Calcium Oxalate Stones

The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis

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