Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway

Liu, Liu; Liu, Yu Lan; Liu, Gong Xiang; Chen, Xi; Yang, Kun; Yang, Yu‐Shang; Xie, Quan; Gan, Hua; Huang, Xiao Li; Gan, Hua

doi:10.1016/j.intimp.2013.06.020

Cited by 74 publications

(61 citation statements)

References 39 publications

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“…Similar results were also described by other authors [11,23]. Increased thickness of the muscularis externa [23,24], submucosal exudate [9,20,22,24], intense cellular infiltration [17,23,24], and areas of hemorrhage [9] were findings observed in previous studies and also noticed in the present study in group II.…”

Section: Discussionsupporting

confidence: 93%

“…Similar findings were reported by other investigators [22]. Cryptal distortion and dilatation with loss of goblet cells was also noticed in the colitis group.…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, these transcriptional molecules are considered to be ideal targets for the molecular therapy of UC. For this purpose, extensive efforts have been made to develop new therapeutic drugs aimed at decreasing the production of proinflammatory cytokines at the transcriptional levels [22]. Under these backgrounds, great attention has been paid to EVOO because it has recently been demonstrated to be a potent inhibitor of NF-κB.…”

Section: Discussionmentioning

confidence: 99%

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Possible protective effect of dietary extra-virgin olive oil on experimentally induced acute colitis in adult male albino rats

Hamam¹,

Raafat²,

Shoukry³

2014

The Egyptian Journal of Histology

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Section: Discussionsupporting

confidence: 93%

“…Similar findings were reported by other investigators [22]. Cryptal distortion and dilatation with loss of goblet cells was also noticed in the colitis group.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Possible protective effect of dietary extra-virgin olive oil on experimentally induced acute colitis in adult male albino rats

Hamam¹,

Raafat²,

Shoukry³

2014

The Egyptian Journal of Histology

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“…Typically, acute colitis is induced in male and female C57BL/6NTac, C57BL/6 and BALB/C mice by incorporating 3 to 5% DSS (w/v) in drinking water ad libitum for 5~8 days [58,63,70,71,72,73,74,75,76]. Afterwards, colons are dissected and examined for histological changes, tissue cytokine levels i.e.…”

Section: Chemical Induced Models Of Chronic Intestinal Inflammationmentioning

confidence: 99%

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

Randhawa

Singh

et al. 2014

Korean J Physiol Pharmacol

375

310

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Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological factors involved in the perpetuation of IBD remain uncertain, development of various animal models provides new insights to unveil the onset and the progression of IBD. Various chemical-induced colitis models are widely used on laboratory scale. Furthermore, these models closely mimic morphological, histopathological and symptomatical features of human IBD. Among the chemical-induced colitis models, trinitrobenzene sulfonic acid (TNBS)-induced colitis, oxazolone induced-colitis and dextran sulphate sodium (DSS)-induced colitis models are most widely used. TNBS elicits Th-1 driven immune response, whereas oxazolone predominantly exhibits immune response of Th-2 phenotype. DSS-induced colitis model also induces changes in Th-1/Th-2 cytokine profile. The present review discusses the methodology and rationale of using various chemical-induced colitis models for evaluating the pathogenesis of IBD.

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“…With respect to its protective effects in UC, numerous preclinical studies have shown that when administered orally or systemically, either as a prophylactic or curative agent, curcumin improved the survival rate, and decreased the wasting and discomfort induced by various ulcerogens, such as DSS,[126127128129130] dinitrobenzene sulfonic acid (DNB),[131] dinitrochlorobenzene (DNCB),[132] TNBS,[133134] acetic acid, and also in genetically predisposed IL-10-knockout[135136] and mdr1a-/- mice. [137138] The results from these observations have all been summarized in Table 1.…”

Section: Spices With Anti-ibd Effectsmentioning

confidence: 99%

Dietary Agents and Phytochemicals in the Prevention and Treatment of Experimental Ulcerative Colitis

Saxena

Kaur

Hegde

et al. 2014

Journal of Traditional and Complementary Medicine

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Inflammatory bowel diseases (IBDs), consisting mainly of ulcerative colitis (UC) and Crohn's disease (CD), are important immune-mediated diseases of the gastrointestinal tract. The etiology of the disease includes environmental and genetic factors. Its management presents a constant challenge for gastroenterologists and conventional surgeon. 5-Amninosalicylates, antibiotics, steroids, and immune modulators have been used to reduce the symptoms and for maintenance of remission. Unfortunately, long-term usage of these agents has been found to lead to severe toxicities, which are deterrent to the users. Pre-clinical studies carried out in the recent past have shown that certain dietary agents, spices, oils, and dietary phytochemicals that are consumed regularly possess beneficial effects in preventing/ameliorating UC. For the first time, this review addresses the use of these dietary agents and spices in the treatment and prevention of IBD and also emphasizes on the mechanisms responsible for their effects.

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Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway

Cited by 74 publications

References 39 publications

Possible protective effect of dietary extra-virgin olive oil on experimentally induced acute colitis in adult male albino rats

Possible protective effect of dietary extra-virgin olive oil on experimentally induced acute colitis in adult male albino rats

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

Dietary Agents and Phytochemicals in the Prevention and Treatment of Experimental Ulcerative Colitis

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