Curcumin Alleviates Matrix Metalloproteinase-3 and -9 Activities during Eradication of Helicobacter pylori Infection in Cultured Cells and Mice

Kundu, Parag; De, Ronita; Pal, Ipsita; Mukhopadhyay, Asish K.; Saha, Dhira Rani; Swarnakar, Snehasikta

doi:10.1371/journal.pone.0016306

Cited by 72 publications

(55 citation statements)

References 46 publications

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“…A persistent infection by Helicobacter pylori, the bacterial species that causes stomach ulcers, constitutes a significant risk factor for developing gastric cancer (Suganuma et al, 2012;Zabaleta, 2012) either due to chronic inflammation and/or the release of virulence factors (Hatakeyama and Higashi, 2005). Curcumin hence acts through its anti-inflammatory (ForystLudwig et al, 2004;Sintara et al, 2010;Kundu et al, 2011) and bactericidal properties (Mahady et al, 2002;De et al, 2009) while favorably modulating numerous infection-induced, carcinogenesis-related pathways in mucosal epithelial cells (Foryst-Ludwig et al, 2004;Sintara et al, 2010;Kundu et al, 2011) and deterring procarcinogenic signaling in H. pylori (Zaidi Fig. 11.…”

Section: A Curcumin Pharmacokinetics and Pharmacodynamicsmentioning

confidence: 99%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: A Curcumin Pharmacokinetics and Pharmacodynamicsmentioning

confidence: 99%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…In addition, apoptotic and myeloperoxidase activity, along with its inhibitory effect for pepsin was found [13]. Moreover, several other in vivo and in vitro studies explored the inhibitory effect of curcumin against H. pylori growth, consequently eradicate H. pylori infection [22][23][24]. In clinical trials, curcumin supplement alone is still under investigation in which it is expected to play a potential role in suppressing H. pylori growth, and may promote healing of peptic ulcers [25,26].…”

Section: Abbas Et Almentioning

confidence: 99%

“…The inhibitory effect of curcumin monotherapy on IL-1β and TNF-α production in ulcerated gastric mucosa caused by H. pylori infection was documented experimentally [23,24,26,55] and was detected in the human study [56], with some controversy [42]. Kundu et al suggested that curcumin act by two ways against H. pylori infection; first as antibacterial via eradicating H. pylori infection, and second; potentially targeting key molecules involved in the H. pylori -induced gastric diseases [23].…”

Section: Abbas Et Almentioning

confidence: 99%

“…Kundu et al suggested that curcumin act by two ways against H. pylori infection; first as antibacterial via eradicating H. pylori infection, and second; potentially targeting key molecules involved in the H. pylori -induced gastric diseases [23]. In addition, Di Mario et al found that treatment with curcumin significantly reduces the serologic signs of gastric inflammation associated with H. pylori infection despite the persistence of the bacterium [43].…”

Section: Abbas Et Almentioning

confidence: 99%

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Potential Benefit of Curcumin Adjuvant Therapy to the Standard H. Pylori Eradication Therapy in Patients With Peptic Ulcer Disease

Abdulridha¹,

Abbas

Najeb

2017

Asian J Pharm Clin Res

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Objective: This study was designed to explore the benefit of curcumin as adjuvant therapy to the standard Helicobacter pylori eradication triple therapy in both duodenal and gastric ulcers patients.Methods: The present study enrolled 40 patients newly diagnosed endoscopically with peptic ulcer disease to be allocated into group 1 treated with standard H. pylori eradication triple therapy, and group 2 patients treated with curcumin (500 mg) capsules three times daily for 14 days as an adjuvant to standard triple therapy. Stool antigen test, immunoglobulin M serology test, tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and total antioxidant capacity (T-AOC) are measured at the baseline and after 6 weeks of treatment. Results:The result showed that the use of curcumin as adjuvant therapy produced highly significant improvement in healing efficacy which was significantly distinguished in duodenal ulcer patients compared to gastric ulcer groups 2 patients (p<0.05), along with a highly significant reduction in pro-inflammatory IL-1β level in group 2 patients (p<0.01). After 6 weeks of treatment, there was a highly significant elevation in the level of TNF-α in groups 1 (p<0.01), though group 2 patients presented with non-significant elevation in TNF-α level. Moreover, the T-AOC was improved with curcumin adjuvant therapy, though non-significant, compared to group 1 patients who showed a reduction in T-AOC. Conclusion:This study revealed that addition of curcumin as adjuvant therapy produced improvement in ulcer healing efficacy, and controlled the inflammatory and oxidative stress process induced by H. pylori infection.

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“…Not surprisingly, curcumin has been evaluated as a potential anti-H. pylori agent. Curcumin supplementation was found to significantly downregulate MMP3 and MMP9 activities (25). A mouse study showed that orally-given curcumin caused significant inhibition of gastric inflammation induced by H. pylori infection (26).…”

Section: Discussionmentioning

confidence: 99%

Erratum to effects of curcumin on Helicobacter pylori infection

2017

Ann. Transl. Med.

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Background: Curcumin is a well-established natural molecule with significant biological and pharmaceutical effects. Its effects on Helicobacter pylori (H. pylori) infection have been repeatedly confirmed both in animal and human models. This study directly compared four different samples to evaluate if the effects are general or if they differ among samples.Methods: Using a mouse model, we studied the effects of curcumin on lipid peroxide (LPO) level, myeloperoxidase (MPO) and urease activity, number of colonized bacteria, levels of anti-H. pylori antibodies, biofilm formation, IFN-γ, IL-4, gastrin and somatostatin levels in serum, and minimum inhibitory concentration.In addition, we evaluated the effects on biofilm production and antibacterial antibody response.Results: In all tests, one sample (Sabinsa) was consistently the most active.Conclusions: All curcumin samples showed some anti-H. pylori effects, but only some of the tested samples had significant activity.Keywords: Biofilm; curcumin; Helicobacter pylori (H. pylori) Erratum Erratum to effects of curcumin on Helicobacter pylori infection doi: 10.21037/atm.2017.03.13 View this article at: http://dx.doi.org/10.21037/atm.2017.03.13 IntroductionHelicobacter pylori (H. pylori) is a Gram-negative bacterium that selectively colonizes the human gastric epithelium and is epidemiologically linked to stomach and colorectal cancer (1). In addition, it is implicated in the etiology of gastritis and peptic ulcers. Antibody therapy coupled with other treatments is highly effective, but not without complications (2). Over 50% of the world population is infected with these bacteria. The resistance of these bacteria to common antibiotics has been related to the genetic variability and to its ability to develop biofilm (3). In addition, Helicobacter infection has been connected with development of allergies (4).Lately, the focus of numerous investigations has switched to various herbal agents shown to have significant antibacterial activity against H. pylori (5). One of these agents is curcumin (6,7). In addition, curcumin also serves as a biofilm-disrupting agent (8), suggesting multiple roles of curcumin in inhibition of H. pylori infection.Curcumin, commonly known as turmeric, is usually a mixture of three curcumoids (curcumin, demethocycurcumin, and bisdemethoxycurcumin) and volatile oil (9). Numerous studies have reported that curcumin has a wide range of biological activities including antimicrobial, antioxidant, antitumor (10), and anti-inflammatory effects. In addition, curcumin has some immunosuppressive activities (11) including expression of cytokines such as IL-1 and TNF-α (12,13). On the other hand, curcumin enhanced phagocytic activity of macrophages (14). In our study, we compared the antibacterial effects of five different types of curcumin. Methods AnimalsFemale, 8-week-old BALB/c mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA). All animal work was done according to the University of Louisville IACUC protocol. Animals were sacrificed...

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Curcumin Alleviates Matrix Metalloproteinase-3 and -9 Activities during Eradication of Helicobacter pylori Infection in Cultured Cells and Mice

Cited by 72 publications

References 46 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Potential Benefit of Curcumin Adjuvant Therapy to the Standard H. Pylori Eradication Therapy in Patients With Peptic Ulcer Disease

Erratum to effects of curcumin on Helicobacter pylori infection

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