Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review

“…In vitro research is carried out on many different cell lines, mostly cancer cells [ 37 , 38 , 39 , 40 ]. In vivo studies are carried out on animals, most commonly mice and rats, but other species can also be used like gerbils and zebrafish, as shown in Table 1 and Table 2 [ 41 , 42 , 43 , 44 , 45 ].…”

“…Researchers frequently investigate curcumin’s bioavailability, metabolism, and safety profile to enhance its therapeutic potential. It is essential to note that despite its promising attributes, challenges related to curcumin’s low bioavailability have prompted ongoing efforts to develop formulations that improve its absorption and effectiveness in biological systems, what would also be an issue for ferroptosis modulation in rational therapy [ 45 , 50 , 56 , 222 , 225 ].…”

Detoxification of Aflatoxin B1 by Phytochemicals in Agriculture and Food Science

“…Additionally, curcumin mitigates AFB 1 -induced renal toxicity in ducks by inhibiting mitochondrial-mediated oxidative stress, ferritinophagy, and ferroptosis. 63 In summary, curcumin, as a natural phytochemical, exhibits remarkable antioxidant and genotoxicity-protective effects against AFB 1 . The role and mechanism of curcumin in detoxifying AFB1 in livestock have been extensively studied utilizing curcumin, which shows great potential and value as an anti-AFB1 feed additive.…”

“…Overall, curcumin can regulate intracellular signaling pathways associated with antioxidant and inflammatory responses, enhance the antioxidant capacity of the body, reduce the assembly of inflammasomes, and protect the metabolic, immune, and digestive organs of animals exposed to AFB 1 , thereby inhibiting AFB 1 -induced pyroptosis, apoptosis, and cell death. Additionally, curcumin mitigates AFB 1 -induced renal toxicity in ducks by inhibiting mitochondrial-mediated oxidative stress, ferritinophagy, and ferroptosis . In summary, curcumin, as a natural phytochemical, exhibits remarkable antioxidant and genotoxicity-protective effects against AFB 1 .…”

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

“…To provide medical measures for AFB1 poisoning, a range of preventive methods and medicinal substances have been tested in research studies. The application of 400 mg/kg of curcumin in feed to ducks for 21 days to alleviate mycotoxin and AFB1 actions with amelioration of the effects on cell death and increase in oxidative stress was suggested in the study that prevented cell death and nephrotoxicity in ducks [22]. AFB1 was affirmed to induce COX-2 expression in a dose-dependent manner in vivo and in vitro in HepG2 and JEG-3 cells [23].…”