Curcumin: A Promising Agent Targeting Cancer Stem Cells

Zang, Shufei; Liu, Tao; Shi, Junping; Qiao, Liang

doi:10.2174/1871520614666140521114735

Cited by 46 publications

(24 citation statements)

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“…Curcumin is able to suppress the proliferation and survival of cancer cells by directly or indirectly binding to various targets, including transcription factors, growth factors and several proteins that are involved in cell signal transduction pathways (40). c-Myc is an important oncogene that has been shown to be downregulated by curcumin (2).…”

Section: Discussionmentioning

confidence: 99%

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19

Liu

Xiang

et al. 2016

Oncology Letters

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Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression. However, the long non-coding RNA H19 directly inhibits p53 activation and thus promotes gastric cancer progression. The aim of this study was to assess the role of H19 in curcumin-induced proliferative inhibition of gastric cancer. The gastric cancer cell line SGC-7901 was treated with curcumin at different concentrations and time points. The effect of curcumin on proliferation was assessed using cell counting kit-8 assays and flow cytometry with Ki67 staining. In addition, H19 expression was quantified by reverse transcription-quantitative polymerase chain reaction, and apoptosis was evaluated by flow cytometric detection of Annexin V and propidium iodide double staining. The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting. The present study demonstrated that curcumin inhibited the proliferation of SGC7901 cells and suppressed H19 expression in a concentration-dependent manner, while p53 expression was enhanced. Ectopic expression of H19 in SGC7901 cells reversed curcumin-induced proliferative inhibition and downregulated p53 expression. Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis. In addition, curcumin decreased the expression of the c-Myc oncogene, and exogenous c-Myc protein reversed the curcumin-induced downregulation of H19 expression. These results suggested that curcumin inhibits the proliferation of gastric cancer cells by downregulating the c-Myc/H19 pathway. Therefore, curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.

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Section: Discussionmentioning

confidence: 99%

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19

Liu

Xiang

et al. 2016

Oncology Letters

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“…Curcumin was reported modulating various signaling pathways implicated in inflammation, proliferation, invasion, survival, and apoptosis [109-111]. Curcumin was shown to induce TP63 and MYC-Associated factor X (MAX), as well as to inhibit NF-κB in hepatocarcinoma cells, and OCT4 in placenta pluripotent embryonic carcinoma cells (NCCIT) suggesting that these genes could act as potential therapeutic targets, especially for cancer stem cells [112, 113]. Recently, curcumin was found to inhibit the activity of NF-κB and NOTCH1 in human hematopoietic Raji cells of hematopoietic origin by inhibition of Histone DeACetylase (e.g.…”

Section: Transcription Factors and Natural Compoundsmentioning

confidence: 99%

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Ratovitski¹

2017

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Accumulating evidence shows that hallmarks of cancer include: “genetic and epigenetic alterations leading to inactivation of cancer suppressors, overexpression of oncogenes, deregulation of intracellular signaling cascades, alterations of cancer cell metabolism, failure to undergo cancer cell death, induction of epithelial to mesenchymal transition, invasiveness, metastasis, deregulation of immune response and changes in cancer microenvironment, which underpin cancer development”. Natural compounds as bioactive ingredients isolated from natural sources (plants, fungi, marine life forms) have revolutionized the field of anticancer therapeutics and rapid developments in preclinical studies are encouraging. Natural compounds could affect the epigenetic molecular mechanisms that modulate gene expression, as well as DNA damage and repair mechanisms. The current review will describe the latest achievements in using naturally produced compounds targeting epigenetic regulators and modulators of gene transcription in vitro and in vivo to generate novel anticancer therapeutics.

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“…Preclinical studies suggested that curcumin shows an antitumor effect on diverse carcinomas, including retinoblastoma, pancreatic cancer, glioma, lung cancer, colon cancer, hepatoma, breast cancer, cervical carcinoma, leukemia, gastric carcinoma, prostate cancer, melanoma, oral epithelial cancer, bladder cancer and ovarian cancer, etc. [9]. Recent studies have summarized the epigenetic alteration induced by curcumin [10].…”

Section: Natural Compounds Affecting Mirnasmentioning

confidence: 99%

Targeting microRNAs: a new action mechanism of natural compounds

Lin

Liu

et al. 2016

Oncotarget

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Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer. In this review, several natural compounds and their studies about miRNA-related action mechanism were summarized. These studies provide a new insight into action mechanism by which natural compound exerts its bioactivity and a novel treatment strategy, demonstrating natural compound a promising remedy for clinical treatments.

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Curcumin: A Promising Agent Targeting Cancer Stem Cells

Cited by 46 publications

References 0 publications

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19

Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Targeting microRNAs: a new action mechanism of natural compounds

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