Curcumin, a Potential Inhibitor of MMP-2 in Human Laryngeal Squamous Carcinoma Cells HEp2

Mitra, Aparna; Chakrabarti, Jayati; Banerji, Aniruddha; Chatterjee, Amitava; Das, Biswajit

doi:10.1615/jenvironpatholtoxicoloncol.v25.i4.70

Cited by 53 publications

(36 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By degrading the ECM, MMP-2 and -9 make the metastasis of tumor cells possible. A previous study established that curcumin inhibited the expression and activity of MMP-2/-9 in tumor cells (17)(18)(19)(20). In the present study, we observed that curcumin inhibited the expression and activity of MMP-2/-9 in EC cells.…”

Section: Discussionsupporting

confidence: 74%

Curcumin suppresses migration and invasion of human endometrial carcinoma cells

et al. 2015

View full text Add to dashboard Cite

Abstract. Curcumin, a widely used Chinese herbal medicine, has historically been used in anti-cancer therapies. However, the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (EC) are still poorly understood. The purpose of this study was to detect the anti-metastatic effects of curcumin and the associated mechanism(s) in EC. Based on assays carried out in EC cell lines, it was observed that curcumin inhibited EC cell migration and invasion in vitro. Furthermore, following treatment with curcumin for 24 h, there was a decrease in the expression levels of matrix metalloproteinase (MMP)-2 and -9 as well as proteinase activity in EC cells. Moreover, curcumin treatment significantly decreased the levels of the phosphorylated form of extracellular signalregulated kinase (ERK) 1/2. MEK1 overexpression partially blocked the anti-metastatic effects of curcumin. Combined treatment with ERK inhibitor U0126 and curcumin resulted in a synergistic reduction in MMP-2/-9 expression; the invasive capabilities of HEC-1B cells were also inhibited. In conclusion, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 via the suppression of the ERK signaling pathway, suggesting that curcumin is a potential therapeutic agent for EC.

show abstract

Section: Discussionsupporting

confidence: 74%

Curcumin suppresses migration and invasion of human endometrial carcinoma cells

et al. 2015

View full text Add to dashboard Cite

show abstract

“…There is also evidence in the literature that curcumin-induced suppression of cell proliferation results in decreased cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. As shown in hepatocellular cancer cells, curcumin appears to alter the metastatic potential of tumor cells by inhibiting the activity of matrix metalloproteinase-9 (MMP-9) and MMP-2 [79]. In experiments with ex vivo cultured BALB/c mouse peritoneal macrophages, curcumin reduced the production of iNOS mRNA in a concentration-dependent manner.…”

Section: 4mentioning

confidence: 93%

Curcumin as “Curecumin”: From kitchen to clinic

Goel

Kunnumakkara

Aggarwal

2008

Biochemical Pharmacology

1,927

1,290

View full text Add to dashboard Cite

“…In addition to its effects on gene expression, turmeric inhibits the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases [71]. Turmeric has also been shown to inhibit tumor cell invasion and metastasis in vitro by reducing MMP-2 activity and by inhibiting HEp2 (epidermoid carcinoma cell line) cell invasion [74]. …”

Section: Medicinal Plants and Cancermentioning

confidence: 99%

Medicinal Plants and Cancer Chemoprevention

Desai¹,

Qazi²,

Ganju³

et al. 2008

CDM

497

282

View full text Add to dashboard Cite

Cancer is the second leading cause of death worldwide. Although great advancements have been made in the treatment and control of cancer progression, significant deficiencies and room for improvement remain. A number of undesired side effects sometimes occur during chemotherapy. Natural therapies, such as the use of plant-derived products in cancer treatment, may reduce adverse side effects. Currently, a few plant products are being used to treat cancer. However, a myriad of many plant products exist that have shown very promising anti-cancer properties in vitro, but have yet to be evaluated in humans. Further study is required to determine the efficacy of these plant products in treating cancers in humans. This review will focus on the various plant-derived chemical compounds that have, in recent years, shown promise as anticancer agents and will outline their potential mechanism of action.

show abstract

Curcumin, a Potential Inhibitor of MMP-2 in Human Laryngeal Squamous Carcinoma Cells HEp2

Cited by 53 publications

References 0 publications

Curcumin suppresses migration and invasion of human endometrial carcinoma cells

Curcumin suppresses migration and invasion of human endometrial carcinoma cells

Curcumin as “Curecumin”: From kitchen to clinic

Medicinal Plants and Cancer Chemoprevention

Contact Info

Product

Resources

About