Curcumin: A naturally occurring long‐wavelength photosensitizer for diaryliodonium salts

Crivello, James V.; Bulut, Umut

doi:10.1002/pola.21017

Cited by 163 publications

(98 citation statements)

References 33 publications

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“…Our findings corroborate those of other studies aimed at reducing microbial activity by using PDT. 27,29,31,32,52 As the primary odontopathogen present in the supragingival plaque, S. mutans is closely related to enamel caries. Lactobacilli generally colonize after S. mutans have exposed the dentino-enamel interface, and they are often cultured from established carious lesions.…”

Section: Discussionmentioning

confidence: 99%

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Photodynamic Effects of Curcumin Against Cariogenic Pathogens

Araújo

Fontana

Bagnato

et al. 2012

Photomedicine and Laser Surgery

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Background data: The presence of Streptococcus mutans and Lactobacillus acidophilus in dental structure is an indicator of a cariogenic biofilm. Photodynamic therapy is a technique that involves the activation of photosensitizers by light in the presence of oxygen, resulting in the production of reactive radicals capable of inducing cell death. Reduction of bacteria levels can provide additional means of preventing dental caries. Objective: The present study evaluated the susceptibility of planktonic cultures of S. mutans (ATCC 25175) and L. acidophilus (ATCC-IAL-523) from the Adolfo Lutz Institute (IAL) to photodynamic therapy after sensitization with curcumin and exposure to blue light at 450 nm. Methods: Bacterial suspensions of S. mutans and L. acidophilus isolated (as single species) and combined (multspecies) were prepared and then evaluated. Four different groups were analyzed: L-D-(control group), L-D + (drug group), L + D-(light group), and L + D + (photodynamic therapy group). Two different concentrations of curcumin were tested (0.75 and 1.5 g/L) associated with a 5.7 J/cm 2 light emission diode. Results: Significant decreases ( p < 0.05) in the viability of S. mutans were only observed when the bacterial suspensions were exposed to both curcumin and light. Then, reductions in viability of up to 99.99% were observed when using 1.5 g/L of the photosensitizer. The susceptibility of L. acidophilus was considerably lower (21% and 37.6%) for both curcumin concentrations. Conclusions: Photodynamic therapy was found to be effective in reducing S. mutans and L. acidophilus on planktonic cultures. No significant reduction was found for L-D + , proving the absence of dark toxicity of the drug.

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Section: Discussionmentioning

confidence: 99%

“…The drug has a variety of traditional pharmaceutical applications, 31,32 including treatment of liver diseases, wounds, and inflamed joints, as well as for blood purification and microbial effects. 33 Curcumin has proven nontoxic in a number of cell cultures and animal studies.…”

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confidence: 99%

Photodynamic Effects of Curcumin Against Cariogenic Pathogens

Araújo

Fontana

Bagnato

et al. 2012

Photomedicine and Laser Surgery

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“…Polynuclear aromatic compounds are known 136,138,[149][150][151][152][153][154]185 to sensitize and consequently decompose onium salts via electron transfer in the exciplex (Scheme 17). We have recently demonstrated that similar photosensitization action can be achieved by highly conjugated thiophene derivatives such as 3,5-diphenyldithieno[3,2-b:2,3-d]thiophene (DDT).…”

Section: Cationic Polymerizationmentioning

confidence: 99%

Photoinitiated Polymerization: Advances, Challenges, and Opportunities

2010

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The use of photoinitiated polymerization is continuously growing in industry as reflected by the large number of applications in not only conventional areas such as coatings, inks, and adhesives but also high-tech domains, optoelectronics, laser imaging, stereolithography, and nanotechnology. In this Perspective, the latest developments in photoinitiating systems for free radical and cationic polymerizations are presented. The potential use of photochemical methods for step-growth polymerization is also highlighted. The goal is, furthermore, to show approaches to overcome problems associated with the efficiency, wavelength flexibility, and environmental and safety issues in all photoinitiating systems for different modes of activation. Much progress has been made in the past 10 years in the preparation of complex and nanostructured macromolecules by using photoinitiated polymerizations. Thus, the new and emerging applications of photoinitiated polymerizations in the field of biomaterials, surface modification, preparation of block and graft copolymers, and nanocomposites have been addressed.

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“…It has some therapeutic effects on liver diseases, wounds, and inflamed joints, as well as for blood purification and microbial effects. 75 Curcumin has shown no toxic effects on a number of cell cultures and animal studies. It has a broad absorption peak in the 300-500 nm range (maximum 430 nm) and produces strong phototoxic effects.…”

Section: Curcuminmentioning

confidence: 99%

Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota

et al. 2015

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The main goal in endodontic treatment is to eradicate or at least reduce intraradicular microbial population to levels that are more compatible with periapical lesions healing process. Since endodontic infections are polymicrobial in nature, intraradicular survival of endodontic microbiota and their pathogenic properties are influenced by a combination of their virulence factors. The purpose of this article is to review the endodontic microbiota and their respective virulence attributes, as well as perform a literature review of the effects of disinfection procedures in the treatment of endodontic infections to gain best practices. Conventional technique for root canal preparation includes mechanical debridement and application of antimicrobial irrigants. Recently, laser irradiation has been used to enhance the results of root canal treatment through its thermal effect. To reduce thermal side effects, laser activated irrigation (LAI) and photon induced photoacoustic streaming (PIPS) were introduced. Antimicrobial photodynamic therapy (aPDT) by photochemical reaction uses light at a specific wavelength to activate a nontoxic photosensitizer (PS) in the presence of oxygen to produce cytotoxic products. Different PSs are used in dentistry including methylene blue (MB), toluidine blue O (TBO), indocyanine green (ICG) and curcumin. Among different options, ICG could be the best choice due to its peak absorption at wavelength of 808 nm, which coincides with the commercial diode laser devices. Also, this wavelength has more penetration depth compared to other wavelengths used in aPDT.

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Curcumin: A naturally occurring long‐wavelength photosensitizer for diaryliodonium salts

Cited by 163 publications

References 33 publications

Photodynamic Effects of Curcumin Against Cariogenic Pathogens

Photodynamic Effects of Curcumin Against Cariogenic Pathogens

Photoinitiated Polymerization: Advances, Challenges, and Opportunities

Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota

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