Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

Momtazi‐Borojeni, Amir Abbas; Haftcheshmeh, Saeed Mohammadian; Esmaeili, Seyed‐Alireza; Johnston, Thomas P.; Abdollahi, Elham; Sahebkar, Amirhossein

doi:10.1016/j.autrev.2017.11.016

Cited by 162 publications

(91 citation statements)

References 154 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therapeutic effects of curcumin in acute and chronic inflammatory disease have been well documented (Shehzad, Rehman, & Lee, ). Curcumin has been reported to exert therapeutic effects against a range of diseases including cancer (Mirzaei et al, ), osteoarthritis (Panahi, Rahimnia, et al, 2014; Sahebkar & Henrotin, ), anxiety and depression (Esmaily et al, ; Panahi, Badeli, Karami, & Sahebkar, ), dyslipidemia (Cicero et al, ; Ganjali et al, ; Panahi et al, ), metabolic syndrome (Panahi, Hosseini, et al, 2015; Panahi, Khalili, Hosseini, Abbasinazari, & Sahebkar, ), respiratory diseases (Lelli, Sahebkar, Johnston, & Pedone, ), nonalcoholic fatty liver disease (Panahi et al, ; Zabihi, Pirro, Johnston, & Sahebkar, ), type 2 diabetes (Panahi et al, ; Parsamanesh, Moossavi, Bahrami, Butler, & Sahebkar, ), ulcerative colitis (Masoodi et al, ), and systemic lupus erythematosus (Momtazi‐Borojeni et al, ).…”

Section: Introductionmentioning

confidence: 99%

Impact of curcumin on toll‐like receptors

Boozari

Butler²,

Sahebkar

2019

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

Toll‐like receptors (TLRs) have a pivotal role in the activation of innate immune response and inflammation. TLRs can be divided into two subgroups including extracellular TLRs that recognize microbial membrane components (TLR1, 2, 4, 5, 6, and 10), and intracellular TLRs that recognize microbial nucleic acids (TLR3, 7, 8, and 9). Curcumin is a dietary polyphenol from Curcuma longa L. that is reputed to have diverse biological and pharmacological effects. Extensive research has defined the molecular mechanisms through which curcumin mediates its therapeutic effects. One newly defined and important target of curcumin is the TLR, where it exerts an inhibitory effect. In the current study, we focus upon the TLR antagonistic effect of curcumin and curcumin's therapeutic effect as mediated via TLR inhibition. The available evidence indicates that curcumin inhibits the extracellular TLR 2 and 4 and intracellular TLR9 and thereby exerts a therapeutic effect in diseases such as cancer, inflammation, infection, autoimmune, and ischemic disease. Curcumin effectively modulates the TLR response and thereby exerts its potent therapeutic effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of curcumin on toll‐like receptors

Boozari

Butler²,

Sahebkar

2019

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Over the last 60 years, numerous studies have demonstrated that curcumin can be used to treat a wide variety of diseases like cancer (Momtazi & Sahebkar, b; Teymouri, Pirro, Johnston, & Sahebkar, ), type 2 diabetes (Panahi et al, a; Panahi et al, ), neurodegenerative disease (Ghosh, Banerjee, & Sil, ; Monroy, Lithgow, & Alavez, ), hepatic disorders (Alappat & Awad, ; El‐Agamy, ; Panahi et al, ; Panahi et al, b; Rahmani et al, ; Zabihi, Pirro, Johnston, & Sahebkar, ), cardiovascular disease (Cicero et al, ; Ganjali et al, ; Saeidinia et al, ), metabolic disorders (Panahi, Khalili, Hosseini, Abbasinazari, & Sahebkar, a; Sahebkar, ), arthritis (Panahi et al, ; Sahebkar & Henrotin, ), autoimmune disease (Abdollahi, Momtazi, Johnston, & Sahebkar, ; Lelli, Sahebkar, Johnston, & Pedone, ; Momtazi‐Borojeni et al, ), pulmonary disorders (Lelli et al, ), thrombotic disorders (Keihanian, Saeidinia, Bagheri, Johnston, & Sahebkar, ), and inflammatory diseases (Chandran & Goel, ; Funk et al, ; Funk et al, ). Curcumin possesses antioxidant, antibacterial, antifungal, antiviral, and antiatherosclerotic properties.…”

Section: Introductionmentioning

confidence: 99%

Demethoxycurcumin: A naturally occurring curcumin analogue for treating non‐cancerous diseases

Hatamipour

Ramezani

Tabassi

et al. 2019

Journal Cellular Physiology

Self Cite

View full text Add to dashboard Cite

Turmeric extracts contain three primary compounds, which are commonly referred to as curcuminoids. They are curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin. While curcumin has been the most extensively studied of the curcuminoids, it suffers from low overall oral bioavailability due to extremely low absorption as a result of low water solubility and instability at acidic pH, as well as rapid metabolism and clearance from the body. However, DMC, which lacks the methoxy group on the benzene ring of the parent structure, has much greater chemical stability at physiological pH and has been recently reported to exhibit antitumor properties. However, the treatment of noncancerous diseases with DMC has not been comprehensively reviewed. Therefore, here we evaluate published scientific literature on the therapeutic properties of DMC. The beneficial pharmacological actions of DMC include anti-inflammatory, neuroprotective, antihypertensive, antimalarial, antimicrobial, antifungal, and vasodilatory properties. In addition, DMC's ability to ameliorate the effects of free radicals and an environment characterized by oxidative stress caused by the accumulation of advanced glycation end-products associated with diabetic nephropathy, as well as DMC's capacity to inhibit the migration and proliferation of vascular smooth muscle cells following balloon angioplasty are also addressed. This review collates the available literature regarding the therapeutic possibilities of DMC in noncancerous conditions.

show abstract

“…Curcumin is a natural phenolic compound that has been shown to be effective in cancer treatment [3,4]. In addition, it has been reported to have antioxidant [5], anti-inflammatory [6,7], liver protection [8], analgesia and antiarthritis [9], lipid modification [10,11], immune regulation [12,13], and antidiabetic [14,15] properties. e above pharmacological properties are attributed to the reactive functional groups in the curcumin chemical structure.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma

Zhang

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Curcumin has been shown to have anticancer effects in a variety of tumors. However, there are fewer studies on the role of curcumin in endometrial carcinoma (EC). The purpose of this experiment was to examine the inhibitory effect of curcumin on endometrial carcinoma cells and ERK/c-Jun signaling pathway. We first predicted the mechanism of action of curcumin on endometrial carcinoma by network pharmacology. Then, we found that curcumin can decrease the cell viability of Ishikawa cells, inhibit the migration of cancer cells, induce apoptosis, and cause cell cycle arrest in the S phase. For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun. This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity.

show abstract

Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

Cited by 162 publications

References 154 publications

Impact of curcumin on toll‐like receptors

Impact of curcumin on toll‐like receptors

Demethoxycurcumin: A naturally occurring curcumin analogue for treating non‐cancerous diseases

Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma

Contact Info

Product

Resources

About