Curcumin (a constituent of turmeric): New treatment option against COVID‐19

Babaei, Fatemeh; Nassiri‐Asl, Marjan; Hosseinzadeh, Hossein

doi:10.1002/fsn3.1858

Cited by 115 publications

(120 citation statements)

References 132 publications

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“…The inflammatory response has led researchers to believe that there might be possible differences in the redox profile of patients with COVID-19 [ 8 , 15 , 16 ], and thus, the use of antioxidants as a complementary therapeutic strategy in COVID-19 has been proposed [ [37] , [38] , [39] , [40] ]. Oxidative stress affects the immune system through altering the immune cell function and inflammatory response [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Gadotti

Lipiński

Vasconcellos

et al. 2021

Free Radical Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Gadotti

Lipiński

Vasconcellos

et al. 2021

Free Radical Biology and Medicine

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“…Decreased expression and secretion of IL-1β and IL-6 was observed in the COVID-19 patients. However, there was no positive effect on the IL-18 mRNA expression and TNFα concentration with the treatment of nano-curcumin (Babaei et al, 2020;Valizadeh et al, 2020;Zahedipour et al, 2020). Being a natural spice extract, curcumin is safe and has low toxicity.…”

Section: Curcuminmentioning

confidence: 91%

Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19

et al. 2021

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The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat the infection and the absence of a suitable vaccine to prevent it. While some individuals contracting the SARS-CoV-2 infection exhibit a well coordinated immune response and recover, others display a dysfunctional immune response leading to serious complications including ARDS, sepsis, MOF; associated with morbidity and mortality. Studies revealed that in patients with a dysfunctional immune response, there is a massive cytokine and chemokine release, referred to as the ‘cytokine storm’. As a result, such patients exhibit higher levels of pro-inflammatory/modulatory cytokines and chemokines like TNFα, INFγ, IL-1β, IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, MCSF, HGF and chemokines CXCL8, MCP1, IP10, MIP1α and MIP1β. Targeting this cytokine storm is a novel, promising treatment strategy to alleviate this excess influx of cytokines observed at the site of infection and their subsequent disastrous consequences. Natural immunosuppressant compounds, derived from plant sources like curcumin, luteolin, piperine, resveratrol are known to inhibit the production and release of pro-inflammatory cytokines and chemokines. This inhibitory effect is mediated by altering signal pathways like NF-κB, JAK/STAT, MAPK/ERK that are involved in the production and release of cytokines and chemokines. The use of these natural immunosuppressants as adjuvants to ameliorate the cytokine storm; in combination with antiviral agents and other treatment drugs currently in use presents a novel, synergistic approach for the treatment and effective cure of COVID-19. This review briefly describes the immunopathogenesis of the cytokine storm observed in SARS-CoV-2 infection and details some natural immunosuppressants that can be used as adjuvants in treating COVID-19 disease.

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“…Curcumin is a multipotential compound from C. longa that possesses diverse medicinal properties. It is a potent anti-inflammatory agent that is effective against numerous chronic diseases [ 14 , [440] , [441] , [442] , [443] ].…”

Section: Curcumin and Covid-19mentioning

confidence: 99%

“…Thus, several studies have hypothesized that the immunomodulatory and anti-viral activities of curcumin might be beneficial in the treatment of SARS-CoV-2 and COVID-19 associated diseases [ 182 , 440 ], [470,476-481]. Curcumin possesses a huge potential as a drug against SARS-CoV-2 as well as COVID-19-associated diseases.…”

Section: Curcumin and Covid-19mentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Curcumin (a constituent of turmeric): New treatment option against COVID‐19

Abstract: In late December 2019, the outbreak of respiratory illness was reported in Wuhan, China. After a while, the cause of this unknown pneumonia was recognized as a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by World

Cited by 115 publications

References 132 publications

Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Susceptibility of the patients infected with Sars-Cov2 to oxidative stress and possible interplay with severity of the disease

Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19

COVID-19, cytokines, inflammation, and spices: How are they related?

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