Curcumin-3,4-Dichloro Phenyl Pyrazole (CDPP) overcomes curcumin's low bioavailability, inhibits adipogenesis and ameliorates dyslipidemia by activating reverse cholesterol transport

Gupta, Abhishek; Singh, Vinay Kumar; Kumar, Durgesh; Yadav, Pragya; Kumar, Santosh; Beg, Muheeb; Shankar, Kripa; Varshney, Salil; Rajan, Sujith; Srivastava, Ankita; Choudhary, Rakhi; Balaramnavar, Vishal M.; Bhatta, R. S.; Narender, Tadigoppula; Gaikwad, Anil Nilkanth

doi:10.1016/j.metabol.2017.05.005

Cited by 29 publications

(34 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, CDPP treatment decreased C/EBPα, αP2, SREBP1c and PPARy mRNA and FAS protein levels. Lipid metabolism and fatty acid synthase protein levels were reduced with CDPP treatment [68]. Mitochondrial biogenesis (UCP1 and PGC-1α) protein levels were increased, as well as oxygen consumption rate, suggesting enhanced energy utilization.…”

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 98%

“…Mitochondrial biogenesis (UCP1 and PGC-1α) protein levels were increased, as well as oxygen consumption rate, suggesting enhanced energy utilization. CDPP treatment increased G1-phase cell cycle arrest and further arrest in S-phase, while cyclin D1, cyclin D3, CDK2, CDK4 and CDK6 protein levels were reduced (Table 1) [68].…”

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 98%

“…Treatment of 3T3-L1 adipocytes with curcumin-3,4-dichloro phenyl pyrazole (CDPP) (20 µM) for 7 days resulted in significant inhibition of adipocyte differentiation and decreased lipid accumulation [68]. In addition, CDPP treatment decreased C/EBPα, αP2, SREBP1c and PPARy mRNA and FAS protein levels.…”

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approaches to prevent and manage/treat the disease better. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (I of II) summarizes the existing in vitro studies examining the antidiabetic effects of curcumin, while a second (II of II) review summarizes evidence from existing in vivo animal studies and clinical trials focusing on curcumin’s antidiabetic properties.

show abstract

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 98%

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 98%

See 1 more Smart Citation

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

View full text Add to dashboard Cite

show abstract

“…Several isoxazole and pyrazole derivatives of curcumin were synthesized for exploration of the utility of the carbonyl and hydroxy groups of curcumin in PKC binding. [51] Isoxazole analogs are the most active group, with mono-O-methylcurcumin isoxazole being the most active compound (MIC 0.09 mg/mL) against Mycobacterium tuberculosis. [50] Numerous semicarbazone and pyrazole derivatives of curcumin have been synthesized as potential mitigation agents to cure acute radiation syndrome (ARS).…”

Section: Curcumin Pyrazole and Isoxazole Analogs And Their Other Vamentioning

confidence: 99%

“…CDPP demonstrated manifest enhancement in gastrointestinal firmness and bioavailability in vivo as compared to curcumin. [51] Isoxazole analogs are the most active group, with mono-O-methylcurcumin isoxazole being the most (1), the parent compound, and was approximately 18-and 2-fold more active than the standard drugs kanamycin and isoniazid, respectively. [76] Pyrazole and isoxazole derivatives of fluorinated curcuminoid were performed for computational/docking and in vitro bioassay against leukemia cell lines by cell viability assay.…”

Section: Curcumin Pyrazole and Isoxazole Analogs And Their Other Varimentioning

confidence: 99%

Recent Updates in Curcumin Pyrazole and Isoxazole Derivatives: Synthesis and Biological Application

Patel

Halpani

2019

Chemistry & Biodiversity

View full text Add to dashboard Cite

Curcumin is an admired, plant-derived compound that has been extensively investigated for diverse range of biological activities, but the use of this polyphenol is limited due to its instability. Chemical modifications in curcumin are reported to seize this limitation; such efforts are intensively performed to discover molecules with similar but improved stability and better properties. Focal points of these reviews are synthesis of stable pyrazole and isoxazole analogs of curcumin and application in various biological systems. This review aims to emphasize the latest evidence of curcumin pyrazole analogs as a privileged scaffold in medicinal chemistry. Manifold features of curcumin pyrazole analogs will be summarized herein, including the synthesis of novel curcumin pyrazole analogs and the evaluation of their biological properties. This review is expected to be a complete, trustworthy and critical review of the curcumin pyrazole analogs template to the medicinal chemistry community.

show abstract

FeCl₃/PVP as Green Homogeneous Catalyst to Synthesize 5‐Amino‐1H‐Pyrazole‐4‐Carbonitriles from Malononitrile Derivatives

Elnagdy

Sarma

2019

ChemistrySelect

View full text Add to dashboard Cite

The homogenous catalytic system “FeCl3/PVP” and green solvent system “water/PEG‐400” has been presented as a green pathway to synthesize 4‐amino‐1‐aryl‐1H‐pyrazole‐4‐carbonitrile and its derivatives from a series of phenyl hydrazines and malononitriles. The new approach enhanced the reaction yield of the desired product up to 97% in 2–4 h time whereas the traditional thermal method gives only 87% maximum yield in relatively longer reaction time (3‐7 h). The catalytic system has remarkable benefits such as it is inexpensive, stable, easy to prepare and very efficient with a small loading of FeCl3 (5 mol%).

show abstract

Curcumin-3,4-Dichloro Phenyl Pyrazole (CDPP) overcomes curcumin's low bioavailability, inhibits adipogenesis and ameliorates dyslipidemia by activating reverse cholesterol transport

Cited by 29 publications

References 34 publications

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Recent Updates in Curcumin Pyrazole and Isoxazole Derivatives: Synthesis and Biological Application

FeCl₃/PVP as Green Homogeneous Catalyst to Synthesize 5‐Amino‐1H‐Pyrazole‐4‐Carbonitriles from Malononitrile Derivatives

Contact Info

Product

Resources

About

Curcumin-3,4-Dichloro Phenyl Pyrazole (CDPP) overcomes curcumin's low bioavailability, inhibits adipogenesis and ameliorates dyslipidemia by activating reverse cholesterol transport

Cited by 29 publications

References 34 publications

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Recent Updates in Curcumin Pyrazole and Isoxazole Derivatives: Synthesis and Biological Application

FeCl3/PVP as Green Homogeneous Catalyst to Synthesize 5‐Amino‐1H‐Pyrazole‐4‐Carbonitriles from Malononitrile Derivatives

Contact Info

Product

Resources

About

FeCl₃/PVP as Green Homogeneous Catalyst to Synthesize 5‐Amino‐1H‐Pyrazole‐4‐Carbonitriles from Malononitrile Derivatives