Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

Zhang, Ruonan; Pan, Ting; Yu, Xiang; Zhang, Mingming; Xie, Han; Liang, Zimao; Bi, Chen; Xu, Cong; Wang, Jing; Huang, Xingxing; Zhu, Qianru; Zhao, Zi-Ming; Gao, Quan; Wen, Chengyong; Liu, Wen‐Cheng; Ma, Weirui; Jiao, Feng; Sun, Xueni; Duan, Ting; Leung, Elaine Lai‐Han; Xie, Tian; Wu, Qibiao; Sui, Xinbing

doi:10.1016/j.bioactmat.2021.11.013

Cited by 99 publications

(80 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, EC-EXos can reduce the degree of damage caused by ferroptosis by inhibiting iron overload in the phagocytic dependence of ferritin ( 23 ). In another study on the mechanism of lung cancer, it was found that lncRNA H19 may inhibit the transcription level of FTH1 by competitively binding miRNA-19b-3p, so as to protect lung cancer cells from iron death injury, thus weakening the effect of anticancer drugs ( 24 ). It can be seen that iron death has potential physiological function and pathological mechanism in the process of tumor suppression and immune monitoring, and has a clear guiding role for targeted therapy ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis

Yan

Zhang

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. Other evidence supports that ferroptosis is participated osteoporotic bone remodeling, predominantly affecting the interaction between bone formation and bone resorption, explicitly bone resorption exceeded bone formation. Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP).

show abstract

Section: Introductionmentioning

confidence: 99%

Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis

Yan

Zhang

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…For example, the overexpression of lncRNA H19 was reported to function as a competing endogenous RNA to enhance the activity of ferroptosis. 15 These findings suggest that the ferroptosis-lncRNA relationship may have relevant and important functions in terms of prognostic prediction and treatment in patients with HCC.…”

Section: Introductionmentioning

confidence: 77%

A prognostic signature based on the expression profile of the ferroptosis-related long non-coding RNAs in hepatocellular carcinoma

Lin¹,

Yang²

2022

Adv Clin Exp Med

View full text Add to dashboard Cite

Background.Ferroptosis is a special form of cell death with extensive biological associations with various cancers; however, the role of aberrantly expressed ferroptosis-related long non-coding RNAs (lncRNAs) in hepatocellular carcinoma (HCC) remains unclear.Objectives. To explore the role and prognostic value of ferroptosis-related lncRNAs in HCC and to screen potential therapeutic targets. Materials and methods.The RNA-seq data for 424 HCC patients and clinical data for 377 HCC patients were obtained from The Cancer Genome Atlas (TCGA) and evaluated using the Pearson's test to identify differentially expressed lncRNAs. The univariate analysis, least absolute shrinkage and selection operator Cox regression analysis were performed to construct and validate a prognostic risk-score model. The prognostic capacity was evaluated using the Kaplan-Meier method, univariate and multivariate Cox regression, and receiver operating characteristic (ROC) curve analyses. The enrichment analysis was performed to explore the functions of ferroptosis-related lncRNAs from the perspective of tumor immunology.Results. Seventeen differentially expressed lncRNAs were identified (AL139384.1, AL928654.1, MKLN1-

show abstract

“…no. C8267; Sigma-Aldrich; Merck KGaA; 1 ml DMSO diluted in 100 ml corn oil); surgery group: corn oil; curcumenol group: 50 mg curcumenol pre-dissolved in 1 ml DMSO and then diluted in 100 ml corn oil]; two times a week at 4 mg/kg/time ( Wang et al, 2021 ; Zhang et al, 2022 ). At the end of the experimental period, all mice were sacrificed, and the spine was extracted, cleaned of soft tissues, and the vertebral column fixed in 4% PFA.…”

Section: Methodsmentioning

confidence: 99%

Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFα/NFκB Pathway

Yang

Tian

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Low back pain (LBP) caused by intervertebral disc degeneration (IVDD) is accredited to the release of inflammatory cytokines followed by biomechanical and structural deterioration. In our study, we used a plant-derived medicine, curcumenol, to treat IVDD. A cell viability test was carried out to evaluate the possibility of using curcumenol. RNA-seq was used to determine relative pathways involved with curcumenol addition. Using TNFα as a trigger of inflammation, the activation of the NF-κB signaling pathway and expression of the MMP family were determined by qPCR and western blotting. Nucleus pulposus (NP) cells and the rats’ primary NP cells were cultured. The catabolism status was evaluated by an ex vivo model. A lumbar instability mouse model was carried out to show the effects of curcumenol in vivo. In general, RNA-seq revealed that multiple signaling pathways changed with curcumenol addition, especially the TNFα/NF-κB pathway. So, the NP cells and primary NP cells were induced to suffer inflammation with the activated TNFα/NF-κB signaling pathway and increased expression of the MMP family, such as MMP3, MMP9, and MMP13, which would be mitigated by curcumenol. Owing to the protective effects of curcumenol, the height loss and osteophyte formation of the disc could be prevented in the lumbar instability mouse model in vivo.

show abstract

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis

Cited by 99 publications

References 48 publications

Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis

Research Progress of Ferroptosis Regulatory Network and Bone Remodeling in Osteoporosis

A prognostic signature based on the expression profile of the ferroptosis-related long non-coding RNAs in hepatocellular carcinoma

Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFα/NFκB Pathway

Contact Info

Product

Resources

About