Curcumae Radix: a review of its botany, traditional uses, phytochemistry, pharmacology and toxicology

Abstract

Objectives Curcumae Radix, the medicinal part is radix, commonly called as Yujin (Chinese:郁金), is a widely used traditional Chinese medicine for its high medicinal value and health benefits. Curcumae Radix has been used to treat conditions such as syndrome of heat disease and unconsciousness, epilepsy and internal stagnation of phlegm, qi stagnation and blood stasis, dysmenorrhoea, jaundice, cholelithiasis caused by dampness heat of liver and gallbladder. This review aims to summarize the botany, traditional usages, processing, phytochemistry, quality control, pharmacology and toxicology of Curcumae Radix to better understand its therapeutic potential. Key findings So far, a variety of chemical constituents have been isolated and identified from Curcumae Radix, mainly including volatile oil and diphenylheptanes. Modern research shows that the extracts and compounds from Curcumae Radix possess wide-ranging pharmacological effects, including anti-tumour, hepatoprotective, anti-inflammatory and analgesic, anti-thrombosis, as well as effects on the nervous system and others. Summary Curcumae Radix holds an important position in traditional system of medicine. It is cost-effective and an important plant with curative application in contemporary medicine. However, further in-depth studies are also needed to determine the medical uses of this plant and its chemical constituents, pharmacological activity, quality control and toxicology.

Carbon Dots Derived from Curcumae Radix and Their Heartprotective Effect

“…Curcumae Radix, a traditional herb used since ancient times for the treatment of cardiovascular diseases, is highly effective, environmentally friendly and inexpensive, and is often applied in a fire concoction, which not only increases its effectiveness but also reduces its side effects. 47 Combining the application of Curcumae Radix in traditional Chinese medicine and our team's previous research base, this study reveals for the first time that a novel non-toxic substance has significant anti-myocardial ischemic effects CRC-CDs with a particle size of less than 10 nm were prepared using a simple and green calcination method.…”

Mechanism of traditional Chinese medicine in the treatment of ischemic stroke by intervening ferroptosis pathway based on molecular target prediction and bioinformatics

“…From the data mining results, the components contained in Zanthoxylum bungeanum, Glycyrrhiza uralensis and Polygonum cuspidatum all in uent the ferroptosis phenotype [47][48][49] . Lygodium japonicum, nidus vespae, ginkgo-nut, Chinese holly leaf, herba geranii, spina gleditsiae, euphorbia lunulata, curcumae radix, semen armeniacae amarum,and their active ingredients have antioxidant and anti-in ammatory effects [50][51][52][53][54][55][56][57][58] . These drugs may regulate ferroptosis by inhibiting lipid peroxidation or in ammation-related ferroptosis, and their speci c effects remain to be explored.…”

Based on UPLC/MS/MS and Bioinformatics Analysis to Explore the Difference Substances and Mechanism of Curcumae Radix (Curcuma wenyujin) in Dysmenorrhea

“…By adding vinegar and high-temperature processing, the components volatilize with the temperature rise, and the dissolution of active ingredient increase, which enhances the effect of dispersing the blood accumulation, soothing the liver, relieving pain, detoxification, and so on. [5][6][7][8] Under the condition of high temperature and acid, the material basis of CW changed significantly, resulting in both similarities and differences in its efficacy.…”