Curcuma longa Extract Protects against Gastric Ulcers by Blocking H2 Histamine Receptors

Abstract

Curcuma longa (C. longa), a common Indian dietary pigment and spice, has been used therapeutically in traditional folk medicine for a wide range of ailments, including wound healing, urinary tract infection, and liver ailments.1,2) Although evidence suggests that a C. longa extract also has considerable gastroprotective and antiulcerogenic effects, 3,4)

Curcumin in Combination With Triple Therapy Regimes Ameliorates Oxidative Stress and Histopathologic Changes in Chronic Gastritis-Associated Helicobacter Pylori Infection

“…Another study about NSAID-induced gastric damage showed that curcumin can increase catalase and superoxide as well as nitric oxide levels in the gastric mucosa (6,25) . The beneficial effects of curcumin on gastritis can be created by the inhibition of gastric acid production due to inhibition of histamine receptors (14) . Another strength point of this study was comparison of the H. pylori eradication rates between triple therapy regimen plus curcumin and triple therapy regimen.…”

“…Packed cell lyses were prepared with distilled water in a ratio of 1:10 to measure the markers. Successful H. pylori eradication was defined as a negative 14 C-urea breath test result and a negative H. pylori stool antigen test result 4 weeks after discontinuation of therapy (22) .…”

“…According to previous studies, successful H. pylori eradication was defined as a negative 14 C-urea breath test result and a negative H. pylori stool antigen test result 4 weeks after end of treatment.…”

Comparative Evaluation of the Anti-ulcer Activity of Curcumin and Omeprazole during the Acute Phase of Gastric Ulcer—Efficacy of Curcumin in Gastric Ulcer Prevention against Omeprazole

“…Curcuma longa, has been used in traditional remedy for a wide range of ailments, including wound healing, urinary tract infection, and liver ailments [10]. Although, curcumin has been defined as the most active component in C longa and has a considerable gastroprotective and antiulcerogenic effect, its antiulcer potential activity was recently confirmed and reviewed by our laboratory [11].…”

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“…[64] Kim et al [65] discovered the defensive effect of turmeric ethanolic extract against gastric ulcers by blocking H2 histamine receptors (H2R) of male Sprague-Dawley (pylorus-ligated) rats. The effect of C. longa extract was compared to the properties of ranitidine.…”