Curcuma-Based Nutritional Supplement in Patients with Neovascular Age-Related Macular Degeneration

Allegrini, Davide; Raimondi, Raffaele; Angi, Martina; Ricciardelli, Gabriella; Montericcio, Alessio; Borgia, Alfredo; Romano, Mario R.

doi:10.1089/jmf.2020.0199

Cited by 10 publications

(13 citation statements)

References 26 publications

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“…Two studies provided no data about the gender distribution [ 28 , 30 ] and three studies pooled the gender distribution for the intervention and control group [ 26 , 31 , 32 ]. Four studies utilized no placebo supplements [ 24 , 33 , 34 , 35 ]. The disease stages ranged from early AMD up to wet AMD.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

2022

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Purpose: Age-related macular degeneration (AMD) is a neurodegenerative ophthalmic disease. The purpose of this systematic review (SR) and meta-analysis was to evaluate if dietary supplementation alone or in combinations might delay the progression of any of the stages of AMD. Methods: A SR and meta-analysis identifying cohort studies and randomized controlled trials (RCTs) evaluating the effect of supplements in patients diagnosed with AMD. PubMed, Scopus, Web of Science, CINHAL, and Cochrane were searched through 8th October 2021. Results: Twenty studies, examining 5634 participants ranging from 55 to 80 years, were included in the SR. Eight studies were selected for meta-analysis (414 and 216 subjects in the intervention and control groups). Lutein and zeaxanthin plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) supplementation showed significant improvements in best-corrected visual acuity (BCVA) (SMD: −1.99, 95% CI: −3.33, −0.65) compared to the control group. Multifocal electroretinogram results (mfERG) were significantly improved overall (SMD: 4.59, 95% CI: 1.75, 7.43) after L plus Z supplementation. Conclusions: Combinations of lutein and zeaxanthin with n-3 LC-PUFA might be beneficial in preventing AMD progression and deterioration of visual function. Our results encourage initiating further studies with combinations of n-3 LC-PUFA, lutein, and zeaxanthin especially in early AMD patients.

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Section: Resultsmentioning

confidence: 99%

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

2022

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“…Beyond this patient’s list, other natural medicine supplements also demonstrate promise. Curcumin has been shown to be neuroprotective [ 21 ], with curcumin-based nutritional supplements showing potential to reduce injection burden in patients with wet AMD [ 22 ]. Moreover, given increasing evidence of the association between the intestinal microbiota and AMD, further exploration of probiotic treatment in this condition may also be fruitful.…”

Section: Discussionmentioning

confidence: 99%

Complete Resolution of Central Soft Drusen without Geographic Atrophy or Choroidal Neovascularization

Zeng

Garg

Miller

2022

JCM

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The treatment and prevention of dry age-related macular degeneration (AMD) traditionally involve lifestyle modifications and antioxidant supplementation, including the AREDS2 formula. We present a case of a woman with dry AMD in her right eye with several large, confluent central drusen on her exam and optical coherence tomography B-scan. Over the course of a year, the drusen almost completely disappeared, but the retinal layers were preserved without the development of geographic atrophy or choroidal neovascularization. While the exact cause of this phenomenon is unclear, it was thought to be associated with this patient’s strict daily use of numerous dietary supplements. This case highlights the potential in exploring alternative medicine supplements in the treatment of AMD.

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“…In the present study, we performed molecular docking method to evaluate the binding energy of curcuma to the top Evidence-Based Complementary and Alternative Medicine conjugation was helpful to inhibit tumor deterioration in model of mice with Dalton's lymphoma ascites [49]. Oral administration of curcumol-based supplement is a safe and effective anti-VEGF treatment in age-related macular degeneration, resulting in functional outcome improvement [50]. e results in our study revealed that ALB and VEGFA might be the main targets participating in the potential mechanism of curcuma against OSMF.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis

Peng

Jiang

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Oral submucous fibrosis (OSMF) is a chronic, fibrotic disease that affects the oral cavity, showing a high rate of malignant transformation. Curcuma exerts therapeutic potentials in many diseases including OSMF. However, the potential targets and pathways to explain the therapeutic effects of curcuma on OSMF are outside the scope of present knowledge. Herein we intend to reveal the predictive targets and potential pathways of curcuma against OSMF by a network pharmacology-based approach followed by molecular docking technology. Methods. We searched the SymMap, GeneCards, and OMIM database to obtain curcuma and OSMF common targets. The protein-protein interaction (PPI) of curcuma and OSMF common targets were then analyzed, followed by functional enrichment analysis. The best binding mode of curcuma and target proteins was analyzed by molecular docking technology. Results. We collected 290 putative targets of curcuma molecules and 600 known therapeutic targets of OSMF, with 64 curcuma and OSMF common targets sorted out. In the PPI network, there were 63 nodes with 922 edges. The node indicates protein and the line indicates PPI relation. The most enriched GO term in the BP level is “gland development”, followed by “cellular response to chemical stress”, and then “response to oxygen levels”, while the most enriched GO term in CC and MF is “membrane raft” and “cytokine receptor binding”, respectively. We also found 131 KEGG pathways significantly enriched by curcuma and OSMF common targets. The binding energy of curcuma to ALB, TNF, TP53, IL6, and VEGFA was −9.5 kcal/mol, −3.9 kcal/mol, −3.5 kcal/mol, −3.6 kcal/mol, and −8.9 kcal/mol, respectively, which suggested ALB and VEGFA were regarded as main targets involving in the potential mechanism of curcuma against OSMF. Conclusion. The present study illustrated that the therapeutic effects of curcuma on OSMF were achieved by targeting ALB and VEGFA, which giving reference to further drug design and development for OSMF.

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Curcuma-Based Nutritional Supplement in Patients with Neovascular Age-Related Macular Degeneration

Cited by 10 publications

References 26 publications

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

The Effect of Dietary Supplementations on Delaying the Progression of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis

Complete Resolution of Central Soft Drusen without Geographic Atrophy or Choroidal Neovascularization

Mechanistic Investigation of Curcuma Protection against Oral Submucous Fibrosis

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