Curcacycline B, a cyclic nonapeptide from Jatropha curcas enhancing rotamase activity of cyclophilin

New Lignans from Jatropha curcas Linn.

“…The main difference between them was that the hydroxymethyl was replaced by a methyl group in 3, which led to upfield shifts of H-9 [δ H = 1.44 (3H, d, J = 6. 3.84 (1H, m, H-9 a), and 3.77 (1H, m, H-9 b) were assigned to moieties CH(7)/CH(8)/CH 2 (9), CH(7 )/CH(8 )/CH 2 (9 ) and CH(8)/CH (8). The location of two acetoxy groups on C-9 and C-9 was confirmed by HMBC correlations between H-9 and H-9 with the carbonyl carbons at δ C = 170.9 and 170.7, respectively.…”

“…The location of two acetoxy groups on C-9 and C-9 was confirmed by HMBC correlations between H-9 and H-9 with the carbonyl carbons at δ C = 170.9 and 170.7, respectively. In addition, the methoxy groups were positioned on C-4 and C-3 based on NOE correlations between H-5 with the methoxy proton at δ H = 3.89 (3H, s, 4-OCH 3 ) and H-4 with the methoxy proton at δ H = 3.94 (3H, s, 3 -OCH 3 ). Moreover, the NOE cross peaks between H-7 with H-7 and H-9, H-9 with H-8 suggested a relative 7,8-trans-8,8 -trans-7 ,8 -cis configuration.…”

“…The resulting residue was partitioned between AcOEt and H 2 O, and then between BuOH and H 2 O. The AcOEt extract (220 g) was subjected to CC (silica gel, CHCl 3 …”

Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

“…J. curcas has served globally as a source of lamp oil and soap, and also as a medicinal plant for the treatment of dropsy, paralysis, rheumatism, and certain skin diseases for a long time (Jiangsu New Medicinal College, 1977). Previous investigations on the secondary metabolites of J. curcas had resulted in the isolation of diterpenoids (Naengchomnong et al, 1994(Naengchomnong et al, , 1986Ravindranath et al, 2003Ravindranath et al, , 2004Chianese et al, 2011;Wang et al, 2009;Liu et al, 2012), sesquiterpenoids (Wang et al, 2008), flavonoids (Khafagy et al, 1977;Subramanian et al, 1971), lignans (Li et al, 2010), coumarins (Kong et al, 1996;Mitra et al, 1970;Matsuse et al, 1999) and cyclic peptides (Van den Berg et al, 1995;Auvin et al, 1997) with various biological activities. In order to isolate the minor active compounds, we investigated this plant and obtained three new diterpenoids along with nine known ones from the CHCl 3 extract of the root bark.…”

Chemical Constituents of the Plants from Genus Jatropha

“…Cyclic Peptides. In recent years, many cyclic peptides were investigated due to their various activities [53 -61] [55]. In 1995, two novel cyclic peptides, 113 and 114, were isolated from the latex of J. podagrica, which were named podacycline A and B, resp.…”