Curative radiation therapy for very elderly bladder cancer patients with localized disease

Bonet, Marta; Bonfill, Teresa; Nuñez, M.; Verdonces, L. De; Mur, E.; Gallardo, Enrique; Fernández-Morales, L.A.; Aguilar, Alfredo; Prats, J.; Arenas, Meritxell

doi:10.1007/s12094-017-1804-1

Cited by 8 publications

(2 citation statements)

References 21 publications

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“…Preliminary studies have reported a good tolerance in older cancer patients treated with chemotherapy and radiotherapy [43,44]. For instance, there were no difference in survival or grade 3-4 toxicity between older head and neck cancer patients (median age 74, range 70-90) and younger ones treated with concurrent chemoradiation [44].…”

Section: Discussionmentioning

confidence: 99%

Challenges Facing Radiation Oncologists in The Management of Older Cancer Patients: Consensus of The International Geriatric Radiotherapy Group

Popescu

Karlsson²,

Vinh-Hung

et al. 2019

Cancers

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The management of older cancer patients remains difficult because of data paucity. Radiation oncologists need to identify potential issues which could affect treatment of those patients. A workshop was organized in Barcelona among international radiation oncologists with special interest in the management of older cancer patients on April 22, 2018. The following consensus was reached: 1. Older cancer patients often faced unconscious discriminating bias from cancer specialists and institutions because of their chronological age. 2. Advances in radiotherapy techniques have allowed patients with multiple co-morbidities precluding surgery or systemic therapy to achieve potential cure in early disease stages. 3. The lack of biomarkers for frailty remains an impediment to future research. 4. Access to healthcare insurance and daily transportation remains an issue in many countries; 5. Hypofractionation, brachytherapy, or stereotactic techniques may be ideally suited for older cancer patients to minimize transportation issues and to improve tolerance to radiotherapy. 6. Patients with locally advanced disease who are mentally and physically fit should receive combined therapy for potential cure. 7. The role of systemic therapy alone or combined with radiotherapy for frail patients needs to be defined in future clinical trials because of targeted agents or immunotherapy may be less toxic compared to conventional chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Challenges Facing Radiation Oncologists in The Management of Older Cancer Patients: Consensus of The International Geriatric Radiotherapy Group

Popescu

Karlsson²,

Vinh-Hung

et al. 2019

Cancers

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show abstract

“…Postoperative radiotherapy and chemotherapy may be provided for patients with BCs that may recur. 3 Invasive BC is a tumor between benign and malignant BCs, which BC cannot be completely resected because of its important adjacent structure, and is prone to recurrence after operation. 4 In recent years, the emergence of small RNA has provided a new way for us to study the pathogenic genes of BC.…”

Section: Introductionmentioning

confidence: 99%

Increased miR‐323a induces bladder cancer cell apoptosis by suppressing c‐Met

Qiu

Zeng

Fang

et al. 2019

The Kaohsiung J of Med Scie

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The current study aimed to evaluate the expression and role of miR‐323a in the progression of bladder cancer (BC), thereby providing a theoretical basis and potential therapy methods for BC patients. Our data showed that miR‐323a levels were significantly reduced in BC tissues compared with those of non‐cancerous tissues. Meanwhile, miR‐323a was significantly decreased in human BC cell lines (T24, J82, TCCSUP, RT‐112) than that in human normal bladder epithelial cell line SV‐HUC‐1. Furthermore, inhibition of miR‐323a markedly enhanced the migration and invasive capacity of T24 and TCCSUP cells. Moreover, overexpression of miR‐323a significantly prompted the apoptosis of BC cells. Dual luciferase reporter assay and western blot analysis confirmed that c‐Met was a target gene of miR‐323a. More importantly, upregulation of c‐Met significantly prompted BC cell proliferation mainly as a result of the enhanced level of phosphorylation of AKT. This effect could be abolished when c‐Met was silenced in BC cells. In summary, reduced miR‐323a expression in BC contributed to enhanced BC cell proliferation and migration mainly by targeting c‐Met.

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An Overview on Eco-friendly Remediation of Toxic Organic Contaminants from Textile Dyeing Industry Wastewater

Ahila¹,

Vinodini²,

Jenifer

et al. 2021

Emerging Contaminants and Associated Treatment Technologies

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Curative radiation therapy for very elderly bladder cancer patients with localized disease

Abstract: RT with contemporary 3D-CRT techniques after TURBT for MIBC in elderly patients is feasible and well-tolerated. Achieving a maximal response and shortening the total radiation treatment time may improve outcomes and quality of life.

Cited by 8 publications

References 21 publications

Challenges Facing Radiation Oncologists in The Management of Older Cancer Patients: Consensus of The International Geriatric Radiotherapy Group

Challenges Facing Radiation Oncologists in The Management of Older Cancer Patients: Consensus of The International Geriatric Radiotherapy Group

Increased miR‐323a induces bladder cancer cell apoptosis by suppressing c‐Met

An Overview on Eco-friendly Remediation of Toxic Organic Contaminants from Textile Dyeing Industry Wastewater

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