Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism

Li, Qing-Ya; Guo, Zhixin; Deng, Xin; Xu, Liang‐Guo; Gao, Yueqiu; Zhang, Wei; Wang, Xiaosu; Xue, Dongying; Lu, Yi‐Yu; Liu, Ping; Su, Shi‐Bing

doi:10.1155/2013/302131

Cited by 4 publications

(4 citation statements)

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“…b) TCM syndrome identification methods based on omics technologies [13], including proteomic, transcriptomic, metabolomic and bioinformatic analysis in hepatitis B and hepatitis B-caused cirrhosis [14][15][16][17], and dynamic network biomarkers in chronic hepatitis B [18]. c) Efficacy evaluation methods of TCM individualization treatment based on molecular classification of "Disease-Syndrome" in hepatitis B-caused cirrhosis [16].…”

Section: "Integration" Approach Based On the Integration Of Reduction...mentioning

confidence: 99%

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"Characterizing Approaches and Research Methods for Traditional Chinese Medicine Syndrome Differentiation and Treatment in Chronic Liver Diseases"

2021

OAJCAM

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TCM syndrome (a.k.a., ZHENG or Zheng-Hou) is the foundation of clinical diagnoses and treatments for chronic liver diseases (CLDs) in traditional in Chinese medicine (TCM). This Mini-Review introduces research approaches and methods for TCM syndrome differentiation and treatment, including Top-Down, Bottom-Up and Integration approaches. It then summarizes a variety of applications of these methods to help guide the development of more accurate and advanced TCM diagnosis and treatment in CLDs.

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Section: "Integration" Approach Based On the Integration Of Reduction...mentioning

confidence: 99%

“…d) Evaluation methods of clinical TCM syndrome pharmacology in hepatitis B-caused cirrhosis based on genomic [16], transcriptomic [17] and metabolomic analysis [18].…”

Section: "Integration" Approach Based On the Integration Of Reduction...mentioning

confidence: 99%

"Characterizing Approaches and Research Methods for Traditional Chinese Medicine Syndrome Differentiation and Treatment in Chronic Liver Diseases"

2021

OAJCAM

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“…This needs further study on the relationships between genetic variation or mutation and efficacy and safety of TCM treatment. Based on genotyping technologies of pharmacological genomics, previous study has that CYP1A2-G2964A is related to the curative effect of Fuzheng-Huayu tablet, a formula, which is able to improve the clinical symptoms of patients with the deficiency syndrome in hepatitis B caused cirrhosis [6]. Studies on transcriptional profiling and miRNA target network analysis have evidenced the efficacy of Fuzheng-Huayu [7].…”

Section: Accurate Tcm Treatmentmentioning

confidence: 99%

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2017

ACIM

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Precision medicine, based on personalized medicine, is to provide personalized and precise prediction, prevention, diagnosis and treatment by genomic, proteomic, metabolomic and other omics technologies and big data analysis techniques. Guided by the Traditional Chinese Medicine (TCM) theory, we may use the technologies and methods of precision medicine to analyze and mine the TCM "Four Diagnosis" information, to get better understanding of TCM ZHENG. Then we can make accurate ZHENG classification, diagnosis and carry out ZHENG based treatment. Precision medical treatment in TCM focuses on individual diagnosis and treatment in the views of system, like disease process and individual integrity with emphasis on main elements and primary contradictions in the system. The study of accurate diagnosis and treatment based on disease ZHENG is of great importance in TCM. Accurate Diagnosis of ZHENGZHENG, also called TCM syndrome or TCM pattern, is an integral and essential part of TCM theory [1]. A TCM ZHENG, in essence, is a characteristic profile of all clinical manifestations collected by "Four Diagnosis" (observing, listening, asking and feeling), which can be identified by a TCM practitioner. Effective clinical treatments rely on the successful differentiation of a specific ZHENG [2]. Accurate diagnosis is the basis of proper medical treatment. Objective and accurate identification of ZHENG is the premise of effective TCM treatment. The objectification of ZHENG and its essence discovery has always been the focus of TCM research. Accurate diagnosis of disease ZHENG is to objectively collect and analyze the clinical symptoms and signs with the application of system biology, bioinformatics and big data mining technologies etc. Then we may discover the biological material basis and biomarkers of ZHENG and make molecular classification of the phenotypes to explain its development and evolution mechanisms objectively and accurately.Recently, some new technologies and methods such as the System Omics Approach were introduced in ZHENG research, which significantly facilitate the accurate diagnosis of ZHENG [2]. Previous studies have investigated ZHENG classification and biomarkers in chronic hepatitis B and liver cirrhosis, and have found that IL-10-819-C/T loci associated with the deficiency syndrome in hepatitis B caused cirrhosis [3]. Both miR-583 and miR-662 were able to distinguish the Liver and gallbladder damp heat syndrome from liver and kidney yin deficiency syndrome in patients with hepatitis B [4]. Additionally, the expression levels of PNP, AQP7 and PSMD2 were important to distinguish the damp heat syndrome from liver depression and spleen deficiency syndrome in hepatitis B caused cirrhosis [5]. These studies have provided the evidences for further study of ZHENG objectification to make accurate diagnosis of TCM. Accurate TCM TreatmentAccurate TCM treatment is the individualized treatment using herbal medicine or acupuncture and moxibustion based on the accurate identification of ZHENG types, which depends on th...

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“…FZHY tablet exhibits antifibrotic activity by inducing apoptosis in HSC-T6 cells through p38 and SAPK/JNK pathways [ 99 , 104 ], and inhibits liver fibrosis through decreasing transcription of TIMP-1, PDGF-B, and PDGF receptor β1 in vivo [ 99 ]. A study of chronic HBV infection-induced fibrosis and cirrhosis patients showed that its therapeutic efficacy is closely related to the GA plus AA polymorphism of CYP 1 A 2 [ 105 ].…”

Section: Potent Natural Products and Herbal Medicines For The Managemmentioning

confidence: 99%

Potent natural products and herbal medicines for treating liver fibrosis

Chen

et al. 2015

Chin Med

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Liver fibrosis is a wound-healing response to chronic liver injury characterized by progressive inflammation and deposition of extracellular matrix components. The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue. The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways. This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.

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Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism

Cited by 4 publications

References 22 publications

"Characterizing Approaches and Research Methods for Traditional Chinese Medicine Syndrome Differentiation and Treatment in Chronic Liver Diseases"

"Characterizing Approaches and Research Methods for Traditional Chinese Medicine Syndrome Differentiation and Treatment in Chronic Liver Diseases"

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Potent natural products and herbal medicines for treating liver fibrosis

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