Curative effects of the aqueous extract of Tithonia diversifolia (Hemsl.) A. gray (Asteraceae) against ethanol induced-hepatotoxicity in rats

Tsopmejio, Ivan Stève Nguepi; Ngueguim, Florence Tsofack; Gounoue, Racéline Kamkumo; Mbatchou, Adolphe; Dimo, Théophile

doi:10.1515/jbcpp-2019-0370

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…In addition, the increase of the level of MDA also confirm hepatic and renal tissue damages and alteration of the antioxidant defenses to neutralize the ROS [33] . Lipid peroxidation is a process by which ethanol induces hepatotoxicity [12,34] . These disturbances in the antioxidant status is accompanied by tissue damages as observed in the investigated organs.…”

Section: Discussionmentioning

confidence: 99%

Protective potential of aqueous extract from Dichrocephala integrifolia (Linn. f.) O. Kuntze (Asteraceae) on blood and biochemical constituents in ethanol-induced hepato-nephrotoxicity in rats

Mbatchou¹,

Florence²,

Hubert³

et al. 2022

J. Med. Plants Stud.

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Dichrocephala integrifola is a plant used empirically to manage hepatic affections. This study evaluates the preventive effects of the aqueous leave extract of Dichrocephala integrifolia on the blood and biochemical parameters in ethanol-induced hepato-nephrotoxicity in rats. To achieve this, the animals received different treatments (p.o): a normal control group and a negative group receiving respectively distilled water (10 mL/kg) and ethanol 40° (4 g/kg) with distilled water simultaneously; 3 other groups receiving the two doses of the plant extract or Simepar (100 mg/kg) and ethanol simultaneously. At the end of the experimental period, haematological and biochemical analyses were performed. The ingestion of ethanol provoked a decrease (at least p< 0.01) in the liver relative weight. The concentration of RBC, HGB, HCT; MCV; PLT; WBC; LYMP; NEUT; MONO dropped while the levels of WBC raised. Ethanol administration caused an (p< 0.001) increase in malondialdehyde even SOD and catalase activities whereas a decreased in nitrites and GSH was noticed. Transaminase levels, ALP, bilirubin and lipid profile were significantly altered associated with a micro-architectural disorganization materialized by hepatic cytolysis, diffuse infiltration of periportal inflammatory cells and dilation of sinusoids capillaries as well as an architectural disorganization of the kidney parenchyma with leukocyte infiltration. The extract protected the alteration of these parameters. It prevented the amplification of alterations induced by ethanol on hepatic and renal micro-architecture tissue whatever the doses. Data suggest the antioxidant and hepatoprotective activities of the extract, attesting the use of this extract in the treatment of liver affection in traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Protective potential of aqueous extract from Dichrocephala integrifolia (Linn. f.) O. Kuntze (Asteraceae) on blood and biochemical constituents in ethanol-induced hepato-nephrotoxicity in rats

Mbatchou¹,

Florence²,

Hubert³

et al. 2022

J. Med. Plants Stud.

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“…The histopathological and biochemical findings highlighted that ethanol could present a toxic effect on the liver, i.e., in line with the previous data. Additionally, chronic and acute ethanol consumption can cause oxidative damage in the liver tissue [43]. In the first stage of ethanol metabolism, it is converted to acetaldehyde by alcohol dehydrogenase; then, it oxidizes to acetate by the aldehyde dehydrogenase activity [44].…”

Section: Discussionmentioning

confidence: 99%

Effects of Aloysia citriodora Hydroalcoholic Extract on Ethanol-induced Hepatotoxicity in Male Wistar Rats

Habibi

Amiri

Gharehsou

et al. 2021

PBR

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Background: Chronic ethanol consumption presents toxic effects on liver tissue by inducing oxidative stress and inflammation. The antioxidant and anti-inflammatory properties of lemon verbena were established. Objectives: The present study aimed to evaluate the protective effects of the hydroalcoholic extract of Aloysia citriodora (A. citriodora) on ethanol-induced hepatotoxicity in male rats by evaluating inflammatory and oxidative stress factors. Methods: The study animals were randomly divided into 7 groups, (6/group) including control, extract alone (400mg/kg), ethanol 10 mg/kg, vitamin C 500 mg/kg + ethanol 10 mg/kg, and the fifth, sixth and seventh groups respectively received an intraperitoneal injection of 100, 200, and 400 mg/kg of A. citriodora extract plus ethanol once a day for 6 weeks. Oxidative stress parameters, such as glutathione content, lipid peroxidation, protein carbonyl, and reactive oxygen species were measured. Furthermore, inflammation parameters (nitric oxide) and liver damage were evaluated by determining the levels of liver enzymes including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and histopathological examinations. Results: In the liver tissue of the ethanol-receiving group, a significant increase (P<0.001) was observed in ALT, AST, and ALP levels and pathological changes, compared to the control group. There was also a significant increase in the levels of oxidative stress and inflammatory factors. Interestingly, A. citriodora extract could inhibit ethanol-induced liver damage by suppressing oxidative stress and inflammation. Conclusion: A. citriodora extract significantly attenuated inflammation and oxidative stress caused by ethanol. Therefore, it can be suggested as a beneficial supplement for treating ethanol-induced hepatotoxicity.

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Ethnobotanical Survey on Bitter Tea in Taiwan

et al. 2022

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Ethnopharmacological evidence: In Taiwan, herbal tea is considered a traditional medicine and has been consumed for hundreds of years. In contrast to regular tea, herbal teas are prepared using plants other than the regular tea plant, Camellia sinensis (L.) Kuntze. Bitter tea (kǔ-chá), a series of herbal teas prepared in response to common diseases in Taiwan, is often made from local Taiwanese plants. However, the raw materials and formulations have been kept secret and verbally passed down by store owners across generations without a fixed recipe, and the constituent plant materials have not been disclosed.Aim of the study: The aim was to determine the herbal composition of bitter tea sold in Taiwan, which can facilitate further studies on pharmacological applications and conserve cultural resources.Materials and methods: Interviews were conducted through a semi-structured questionnaire. The surveyed respondents were traditional sellers of traditional herbal tea. The relevant literature was collated for a systematic analysis of the composition, characteristics, and traditional and modern applications of the plant materials used in bitter tea. We also conducted an association analysis of the composition of Taiwanese bitter tea with green herb tea (qing-cao-cha tea), another commonly consumed herbal tea in Taiwan, as well as herbal teas in neighboring areas outside Taiwan.Results: After visiting a total of 59 stores, we identified 32 bitter tea formulations and 73 plant materials. Asteraceae was the most commonly used family, and most stores used whole plants. According to a network analysis of nine plant materials used in high frequency as drug pairs, Tithonia diversifolia and Ajuga nipponensis were found to be the core plant materials used in Taiwanese bitter tea.Conclusion: Plant materials used in Taiwanese bitter tea were distinct, with multiple therapeutic functions. Further research is required to clarify their efficacy and mechanisms.

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Curative effects of the aqueous extract of Tithonia diversifolia (Hemsl.) A. gray (Asteraceae) against ethanol induced-hepatotoxicity in rats

Cited by 4 publications

References 23 publications

Protective potential of aqueous extract from <em>Dichrocephala integrifolia </em>(Linn. f.) O. Kuntze (Asteraceae) on blood and biochemical constituents in ethanol-induced hepato-nephrotoxicity in rats

Protective potential of aqueous extract from <em>Dichrocephala integrifolia </em>(Linn. f.) O. Kuntze (Asteraceae) on blood and biochemical constituents in ethanol-induced hepato-nephrotoxicity in rats

Effects of Aloysia citriodora Hydroalcoholic Extract on Ethanol-induced Hepatotoxicity in Male Wistar Rats

Ethnobotanical Survey on Bitter Tea in Taiwan

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