Curative and palliative aspects of regional chemotherapy in combination with surgery

Müller, H; Hilger, Ralf A.

doi:10.1007/s00520-002-0355-2

Cited by 17 publications

(4 citation statements)

References 31 publications

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“…Bei der ILP konnte die lokale Injektion von Chemotherapeutika in die Lunge zusammen mit der lokalen Hyperthermie eine verbesserte Absorption und eine erhöhte zytotoxische Wirkung der applizierten Medikamente schaffen [15]. Muller et al berichteten, dass die Konzentration der Chemotherapeutika an der Tumorstelle doppelt so hoch ist wie bei einer systemischen Chemotherapie [16]. Zahlreiche Tierstudien konnten diese vielversprechenden Ergebnisse bestätigen [17], jedoch konnte sich die ILP klinisch nicht etablieren, da sie nicht reproduzierbar ist.…”

Section: Isolierte Lungenperfusion (Ilp)unclassified

“…In ILP, the local injection of chemotherapeutics into the lung together with local hyperthermia was able to improve absorption and increase the cytotoxic effect of the applied medications [15]. Muller et al reported that the concentration of chemotherapeutics at the tumor site is double the amount in systemic chemotherapy [16]. Numerous animal studies were able to confirm these promising results [17].…”

Section: Isolated Lung Perfusion (Ilp)mentioning

confidence: 99%

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Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors

Vogl

Mekkawy

Thabet

2023

Rofo

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Background Lung cancer incidence has greatly increased over the past century. Moreover, the lung is the most common site of metastatic involvement. Despite improvements in the diagnosis and treatment of lung malignancies, patient prognosis is still unsatisfactory. Locoregional chemotherapeutic techniques for the treatment of lung malignancies are the current focus of research. The aim of this review article is to present different locoregional intravascular techniques and their treatment principles and to assess the pros and cons of each of them as a palliative and neoadjuvant treatment method in the treatment of lung malignancy. Method The different methods for the treatment of malignant lung lesions such as isolated lung perfusion (ILP), selective pulmonary artery perfusion (SPAP), transpulmonary chemoembolization (TPCE), bronchial artery infusion (BAI), bronchioarterial chemoembolization (BACE), and intraarteriel chemoperfusion (IACP) are evaluated comparatively. Results Locoregional intravascular chemotherapy procedures are proving to be promising treatment options in the management of malignant lung tumors. In order to achieve optimal results, the locoregional technique should be used to achieve the highest possible uptake of the chemotherapeutic agent into the target tissue with rapid systemic clearance. Conclusion Among the various treatment options for lung malignancies, TPCE is the best evaluated treatment concept. However, further studies are necessary to define the optimal treatment concept with the best clinical outcomes. Key Points Citation Format

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Section: Isolierte Lungenperfusion (Ilp)unclassified

Section: Isolated Lung Perfusion (Ilp)mentioning

confidence: 99%

Intravascular Treatment Techniques for Locoregional Therapies of Lung Tumors

Vogl

Mekkawy

Thabet

2023

Rofo

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“…HCC receives a majority of their blood supply from the hepatic artery compared to the portal vein for normal liver. In TACE, a catheter is placed in the branches of the hepatic artery and chemotherapy agents can be infused into the artery [105]. Drug eluting beads (DEB) is often used in combination with TACE to deliver chemotherapy into adjacent tissue [106,107].…”

Section: Local Implantationmentioning

confidence: 99%

Liver Cancer: Current and Future Trends Using Biomaterials

Chew

Moscato

George

et al. 2019

Cancers

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Hepatocellular carcinoma (HCC) is the fifth most common type of cancer diagnosed and the second leading cause of death worldwide. Despite advancement in current treatments for HCC, the prognosis for this cancer is still unfavorable. This comprehensive review article focuses on all the current technology that applies biomaterials to treat and study liver cancer, thus showing the versatility of biomaterials to be used as smart tools in this complex pathologic scenario. Specifically, after introducing the liver anatomy and pathology by focusing on the available treatments for HCC, this review summarizes the current biomaterial-based approaches for systemic delivery and implantable tools for locally administrating bioactive factors and provides a comprehensive discussion of the specific therapies and targeting agents to efficiently deliver those factors. This review also highlights the novel application of biomaterials to study HCC, which includes hydrogels and scaffolds to tissue engineer 3D in vitro models representative of the tumor environment. Such models will serve to better understand the tumor biology and investigate new therapies for HCC. Special focus is given to innovative approaches, e.g., combined delivery therapies, and to alternative approaches—e.g., cell capture—as promising future trends in the application of biomaterials to treat HCC.

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“…25,26 With isolated lung perfusion, it is possible to obtain drug concentrations near the tumor site twice as high as those achieved with systemic chemotherapy with only 25% of the systemic dose. 27 Several recent animal studies have reconfirmed that tumor drug concentrations and therapeutic efficacy are significantly higher 28,29 with isolated lung perfusion than with systemic chemotherapy.…”

Section: Isolated Lung Perfusionmentioning

confidence: 99%