Curaderm

Evans, R; Cham, Bill E.; Daunter, B.

doi:10.5694/j.1326-5377.1989.tb136515.x

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…The solanum alkaloids (Figure ) have been used for centuries in traditional anticancer folk medicine in China. Cham et al disclosed that solamargine 4 was extraordinarily effective against melanomas in vivo. A crme (called BEC and later Curaderm) containing solasodine and its dirhamnoglucoside solamargine has been demonstrated to be highly efficacious both in mice in the terminal state of murine leukemia and in humans with advanced melanomas, with complete remission of the cancers in all human tests (56/56 patients, 181/181 lesions in initial clinical trials).…”

Section: Isolation and Biological Activitymentioning

confidence: 99%

Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines † This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani.

2009

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Section: Isolation and Biological Activitymentioning

confidence: 99%

Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines † This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani.

2009

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“…Several steroidal glycoalkaloids from the local plant Solanum linnaeanum possess activity of slowing skin cancer growth in horses and cattle, in which α -solamargine ( 500 ) and α -solasonine ( 501 ) were identified. These two active compounds were subsequently developed into a topical treatment for keratoses, basal cell carcinomas, and squamous cell carcinomas, which were marketed in Australia signed Curaderm [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Chemistry and bioactivities of natural steroidal alkaloids

Xiang

et al. 2022

Nat. Prod. Bioprospect.

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Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga®), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited.

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Antitumor Efficacy of the Novel Chemotherapeutic Agent Coramsine Is Potentiated by Cotreatment With CpG-Containing Oligodeoxynucleotides

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Himbeck

Aarons

et al. 2006

Journal of Immunotherapy

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Coramsine is a novel chemotherapeutic agent isolated from Solanum linnaeanum (devil's apple). Topical treatment provides clinical benefit for skin tumors. To evaluate the potential broader applicability of the drug, its in vivo anticancer efficacy in a murine model of malignant mesothelioma and its mode of action were investigated. Systemic administration of coramsine slowed tumor growth and prolonged survival time. Importantly, the antitumor efficacy of coramsine was enhanced when treatment was combined with stimulation of innate immunity using unmethylated CpG-containing oligodeoxynucleotides (ODNs). Combination treatment further slowed tumor growth and provided a survival benefit. Coramsine seems to kill tumor cells by direct cell lysis. Using 2 different assays to detect apoptosis (caspase activation and DNA fragmentation), we found no evidence that coramsine induces any form of programmed cell death. The fact that the efficacy of coramsine is potentiated by CpG ODNs suggests that coramsine-induced cell death is an immunologic null event.

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Curaderm

Cited by 4 publications

References 3 publications

Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines † This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani.

Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines † This review is dedicated to the community of isolation/identification natural product detectives, with special thanks to the groups of Bob Pettit and Nobuhiro Fusatani.

Chemistry and bioactivities of natural steroidal alkaloids

Antitumor Efficacy of the Novel Chemotherapeutic Agent Coramsine Is Potentiated by Cotreatment With CpG-Containing Oligodeoxynucleotides

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