Cuproptosis mediates copper-induced testicular spermatogenic cell death
Jing-Yi Zhang,
Xu-Jun Yu,
Jun-Jun Li
et al.
Abstract:Cuproptosis, a novel mechanism of programmed cell death, has not been fully explored in the context of spermatogenic cells. This study investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper overload. Sixty male Institute of Cancer Research (ICR) mice were randomly divided into four groups that received daily oral gavage with sodium chloride (control) or copper sulfate (CuSO4) at 50 mg kg−1, 100 mg kg−1, or 200 mg kg−1, for 42 consecutive days. Mice subje… Show more
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